Sickle Crisis Precipitated by Exercise Rhabdomyolysis in a Patient With Sickle Cell Trait: Case Report

Zimmerman, Jack M.; Mummert, Kenneth; Granatir, Robert; Cioffi, Richard F.

doi:10.1093/milmed/139.4.313

Cited by 17 publications

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“…These results could possibly indicate that there is an ab normality in the storage of RBC in spleen among SCT sub jects during exercise. It is known that extreme exertion causes splenic infarction among SCT subjects [10][11][12], Values are mean ±SD (n = 11 for AA and n = 11 for SCT). Mets: The multiple of one metabolic equivalent, where V 0 2 = 3 ml/ min/kg.…”

Section: Discussionmentioning

confidence: 99%

“…Most of these cases have been associated with high ex treme exertion and exposure at high altitudes [1, 2,4 ,6,7]. Nonfatal complications include intravascular coagulation [4,8,9], splenic infarction [10][11][12], rhabdomyolysis and myoglobinuria which may lead to renal failure [4,[8][9][10][11], Values are mean ± SD (n = 11 for AA and n = 11 for SCT). See text for discussion of sta tistical tests.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Physical Stress on Complete Blood Count and Venous Blood Gas Profile of Individuals with Sickle Cell Trait

Hardy¹,

Mukherjee

Hinds³

et al. 1992

Acta Haematol

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The association between sickle cell trait (SCT) and adverse effects of exercise has been controversial. While individuals with SCT are at higher risk of sudden death, the mechanism for this outcome remains to be elucidated. In order to shed light on this controversy, we have monitored venous blood count and blood gas parameter values in normal and SCT subjects during treadmill exercise. White and red blood cell counts and hemoglobin changed significantly over time in both the SCT and normal groups, with peak exercise values different from pre-exercise or post-exercise values. Red blood cell counts showed significant group-time interaction; increase in count during exercise was accentuated in SCT subjects. All blood gas parameters showed significant changes over time in both groups. O₂ content was significantly higher in SCT than AA at all time intervals. O₂ saturation, pO₂ and CO binding to hemoglobin showed significant group-time interaction. Furthermore, O₂ saturation for the combined groups was significantly greater at peak exercise and at rest than before exercise. It is possible that treadmill exercise causes microvascular shunting in SCT subjects, leading to a decrease in the peripheral utilization of oxygen.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Physical Stress on Complete Blood Count and Venous Blood Gas Profile of Individuals with Sickle Cell Trait

Hardy¹,

Mukherjee

Hinds³

et al. 1992

Acta Haematol

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“…One of the earliest (Jones et al , ) described metabolic acidosis, hyperkalaemia and a kind of ‘sickle cell crisis’ in a carrier that occurred abruptly after running 1 mile at mild altitude. Zimmerman et al () described the case of an individual with SCT who developed rhadomyolysis and myoglobinuria after running 3 miles and died 65 h later. Greater attention was focused on this association following the publication of a large epidemiological study that retrospectively evaluated the risk of exercise‐related death in U.S. Armed Forces recruits over a 5‐year period (1977–81) (Kark et al , ).…”

Section: Exercise‐related Complications In Sct Carriersmentioning

confidence: 99%

Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory

2015

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Worldwide, sickle cell trait is a highly prevalent gene carrier state. While generally a benign condition with a normal life expectancy, it is becoming increasingly clear that the sickle trait is associated with certain adverse outcomes. This article will focus on three of these outcomes, namely exertional rhabdomyolysis and sudden death, chronic renal dysfunction, and venous thromboembolism. In each case, the epidemiological evidence for the association is reviewed, together with the existing data on potential underlying mechanisms. Because newborn screening programmes for sickle cell anaemia also identify those with sickle cell trait, it is imperative that further studies determine what, if any, preventive measures can be taken to reduce the burden of these uncommon but potentially morbid complications in affected individuals.

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Severe Metabolic Complications in a Cross-Country Runner With Sickle Cell Trait

Helzlsouer¹

1983

JAMA

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Sickle Crisis Precipitated by Exercise Rhabdomyolysis in a Patient With Sickle Cell Trait: Case Report

Cited by 17 publications

References 0 publications

Effects of Physical Stress on Complete Blood Count and Venous Blood Gas Profile of Individuals with Sickle Cell Trait

Effects of Physical Stress on Complete Blood Count and Venous Blood Gas Profile of Individuals with Sickle Cell Trait

Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory

Severe Metabolic Complications in a Cross-Country Runner With Sickle Cell Trait

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