Sickle cell-induced ischemic priapism

AlDallal, Salma M; AlDallal, Nasser; Alam, Adel Alam Adel

doi:10.1080/2331205x.2016.1268357

Cited by 4 publications

(3 citation statements)

References 81 publications

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“…The association between sickle cell anemia and priapism is well documented in the literature. 19,20 Indeed, this condition accounted for 62% of the patients with blood diseases. Approximately half of the patients in the present study had no previous adverse health condition.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Sociodemographic Profile of Patients with Priapism treated at a University Hospital

Faria¹,

Querichelli²,

Spessoto³

et al. 2019

ijSciences

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Priapism is urological emergency that consists of a prolonged erection for more than four hours, independently of sexual stimulation. Due to its low incidence, the pidemiology is not fully known. The aim of the present study was to investigate the clinical and sociodemographic profile of patients with priapism treated at a university hospital. A retrospective, cross-sectional study was conducted involving the records of patients with priapism treated at an emergency urological service between January 2011 and August 2018. The variables analyzed were age, ethnicity, marital status, previous adverse health conditions, the use of recreational drugs and the number of visits to the hospital by each patient. Forty-two patients with priapism were studied, totaling 178 hospital visits. The analysis of the charts revealed age ranging from 15 to 85 years, with the majority of cases (72%) occurring between 20 and 50 years of age. Regarding ethnicity and marital status, 64% were self-declared white, 22% were self-declared black, 43% were married and 33% were single. Approximately 52% of the patients (n = 22) had a previous adverse health condition. Among these individuals, eight (36%) had a blood disease, the most frequent of which was sickle cell anemia (n = 5; 62.5%). Eleven (26%) patients reported using recreational drugs and 74% made no use of drugs. Analyzing the number of hospital visits per patient, 57% were treated for a single episode and 43% (n = 18) returned more than once to the urological emergency service with the same condition. Based on the present findings obtained from a university hospital, sickle cell anemia was the most frequent condition among the patients. No significant association was found between the use of recreational drugs and the occurrence of priapism. The most affected age group was 20 to 40 years, with a predominance of white, married men.

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Section: Discussionmentioning

confidence: 99%

Clinical and Sociodemographic Profile of Patients with Priapism treated at a University Hospital

Faria¹,

Querichelli²,

Spessoto³

et al. 2019

ijSciences

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show abstract

“…Mientras que el priapismo no isquémico no representa una emergencia médica, el priapismo isquémico agudo que persiste por más de cuatro horas, con gasimetría de acidosis hipercápnica, y poco o ningún flujo sanguíneo cavernoso, para su resolución podría requerir tratamiento emergente. 12,13 Es posible que el priapismo se relacione con casos de mayor riesgo de otras complicaciones de la EF y puede tener desenlaces graves tiempo-dependientes como la disfunción eréctil (DE), 14 las deformidades del pene o la infertilidad. Por lo anterior, el reconocimiento y tratamiento temprano es fundamental para la prevención de las complicaciones y la recurrencia que puede producir DE 2.5 veces más en la EF que en la población general.…”

Section: Introductionunclassified

Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura

Iglesias-Jiménez,

Sierra Merlano,

Toro Osorio

2024

Rev.Col.Hematol.Oncol

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La enfermedad falciforme (EF) comprende un grupo de trastornos hereditarios con expresión clínica heterogénea y múltiples complicaciones de índole vascular y hemolítica. El priapismo representa una emergencia urológica que amerita intervención quirúrgica temprana para disminuir la disfunción eréctil. Objetivos: informar cinco casos de EF atendidos por priapismo en la ESE Hospital Universitario de Cartagena (ESEHUC) resaltando las características sociodemográficas, clínicas y de laboratorio que se asociaron a disfunción eréctil. Métodos: serie de casos hospitalaria. Resultados: se registraron cinco casos de priapismo con mediana calculada para edad de 33 años, IMC: 23 kg/m2, tres casos pertenecieron al subtipo homocigoto, uno doble heterocigoto y un rasgo de la EF. La media de ingreso hospitalario se consideró tardía siendo mayor a 48 horas de evolución del priapismo y en todos se optó por el manejo quirúrgico urológico. Tres casos presentaron disfunción sexual, uno clasificado severo. Conclusiones: los casos con formas subclínicas y genotipos de bajo riesgo pueden enfrentarse a priapismo mayor, con riesgo de padecer complicaciones con impacto sobre la vida sexual. Se insiste en educar a los pacientes sobre la consulta temprana y estilos de vida quedisminuyan el riesgo de priapismo.

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“…There are two recognized subtypes of priapism 1) non ischemic or high flow and 2) ischemic or low flow priapism. Patients with SDC experience ischemic priapism and are more likely to undergo more significant complications such as, progressive fibrosis of the penis, necrosis of corpus cavernosum smooth cells and endothelium and subsequently erectile dysfunction (ED) [5]. Generally, there are various mechanisms attributed to the occurrence of priapism including, diminished outflow from penis veins, an increased level of adenosine, the formation of erythrocytes sludge in vasculature of the penis and reduction of phosphodiesterase-5 (PDE5) due to depleted nitric oxide (NO) levels.…”

Section: Introductionmentioning

confidence: 99%

Molecular Modeling of 3-(1,3-Dioxoisoindolin-2-yl)benzyl Nitrate and its Molecular Docking Study with Phosphodiesterase-5 (PDE5)

Nabati¹,

Bodaghi-Namileh²

2020

Adv. J. Chem. A

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In this study, the electronic properties of the novel medicinal compound 3-(1,3-dioxoisoindolin-2-yl) benzyl nitrate as a treatment of sickle cell disease are obtained using density functional theory (DFT) method. In first step, the molecular structure of the title compound is optimized at B3LYP/6-311++G (d,p) level of theory at room temperature. Then, its stability and reactivity properties are calculated by frontier molecular orbitals (FMOs) energies. The global reactivity indices show this medicinal molecule is a more stable compound and the nitrogen atom of the nitrate group has positive charge. So, the nitrate group can quit nitric oxide molecule in binding to Phosphodiesterase-5 (PDE5) enzyme. On the other hand, the docking analysis of the ligand-enzyme complex shows the steric interactions play the main role in this complex formation. Also, the data shows the PDE5 residues containing Phe [A]

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Sickle cell-induced ischemic priapism

Cited by 4 publications

References 81 publications

Clinical and Sociodemographic Profile of Patients with Priapism treated at a University Hospital

Clinical and Sociodemographic Profile of Patients with Priapism treated at a University Hospital

Priapismo isquémico en la enfermedad falciforme como causa de disfunción sexual. Serie de casos y revisión de la literatura

Molecular Modeling of 3-(1,3-Dioxoisoindolin-2-yl)benzyl Nitrate and its Molecular Docking Study with Phosphodiesterase-5 (PDE5)

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