Sickle cell disease and infection

Nuzzo, Dayana V. P. Di; Fonseca, Silvana Fahel da

doi:10.2223/1218

Cited by 21 publications

(12 citation statements)

References 23 publications

(49 reference statements)

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“…28,29 Encapsulated gram-positive organisms (Haemophilus influenzae type B and pneumococcus) are the most common, and developing acidosis, hypoxemia, and dehydration may be a significant trigger of a sickle cell crisis. Bacterial infection is a well-known complication in patients with SCD and a frequent cause of death, in particular, in adults.…”

Section: Infectious/inflammatory Event As Potential Triggermentioning

confidence: 99%

"Recurrent" Posterior Reversible Encephalopathy Syndrome

Sweany¹,

Bartynski²,

Boardman³

2007

Journal of Computer Assisted Tomography

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In a retrospective review, 3 (3.8%) of 78 patients developed recurrent posterior reversible encephalopathy syndrome. Underlying clinical conditions included sickle cell disease, antibody-positive autoimmune disease, and allogeneic bone marrow transplantation. Infection (bacterial/viral) was suspected or documented in both episodes in all 3 patients. Evidence of endothelial injury (schistocyte formation and increased lactate dehydrogenase) was documented in all patients, and multiple organ dysfunction syndrome developed during the hospital course of all admissions.

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Section: Infectious/inflammatory Event As Potential Triggermentioning

confidence: 99%

"Recurrent" Posterior Reversible Encephalopathy Syndrome

Sweany¹,

Bartynski²,

Boardman³

2007

Journal of Computer Assisted Tomography

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“…Clinical manifestations usually appear after three months of age, when the concentration of fetal hemoglobin (Hb F) decreases 2 . Most systems are liable to vaso-occlusive processes possibly resulting in multisystem failure 4, 5, 6…”

Section: Introductionmentioning

confidence: 99%

Clinical and laboratory profile of patients with sickle cell anemia

Sant’Ana

Araujo

Pimenta

et al. 2017

Revista Brasileira de Hematologia e Hemoterapia

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ObjectiveThis study aimed to describe and analyze clinical and laboratory characteristics of patients with sickle cell anemia treated at the Hemominas Foundation, in Divinópolis, Brazil. Furthermore, this study aimed to compare the clinical and laboratory outcomes of the group of patients treated with hydroxyurea with those patients that were not treated with hydroxyurea.MethodsClinical and laboratorial data were obtained by analyzing medical records of patients with sickle cell anemia.ResultsData from the medical records of 50 patients were analyzed. Most of the patients were female (56%), aged between 20 and 29 years old. Infections, transfusions, cholecystectomy, splenectomy and systemic arterial hypertension were the most common clinical adverse events of the patients. The most frequent cause of hospitalization was painful crisis. The majority of patients had reduced values of hemoglobin and hematocrit (8.55 ± 1.33 g/dL and 25.7 ± 4.4%, respectively) and increased fetal hemoglobin levels (12 ± 7%). None of the clinical variables was statistically significant on comparing the two groups of patients. Among hematological variables only hemoglobin and hematocrit levels were statistically different between patients treated with hydroxyurea and untreated patients (p-value = 0.005 and p-value = 0.001, respectively).ConclusionSickle cell anemia requires treatment and follow-up by a multiprofessional team. A current therapeutic option is hydroxyurea. This drug reduces complications and improves laboratorial parameters of patients. In this study, the use of the drug increased the hemoglobin and hematocrit levels of patients.

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“…HbSS patients present atypical red blood cells (RBCs) with classic sickle-shape that do not circulate properly in the microcirculation, causing blood flow obstruction, hemolysis and vaso-occlusive crisis (VOC) [4]. These events are responsible for the main clinical manifestations of the disease, as well as for significant morbidity and reduction of life expectancy [5]. HbSC patients present target-shape RBC and manifest similar clinical features of those with HbSS, however, in a lower frequency and intensity [6,7].…”

Section: Introductionmentioning

confidence: 99%