Sick Sinus Syndrome

Walsh-Irwin, Colleen; Hannibal, Gerard B.

doi:10.1097/nci.0000000000000099

Cited by 12 publications

(14 citation statements)

References 6 publications

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“…The reported case had many factors that were more likely to cause SSS than the increased ICP. This included old age (84 years old) and ischemic heart disease [ 17 ]. In addition, SSS occurred just after the administration of vagomimetic anesthetic drugs, fentanyl and vecuronium, which was reported to cause SSS and is the most plausible cause in this scenario [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated Intracranial Pressure as a Cause of Sick Sinus Syndrome

Makhaly

Fallah

Giannetti

2018

Case Reports in Cardiology

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Sick sinus syndrome (SSS) has multiple causes both familial and acquired. The most common cause is usually idiopathic. In the past literature, elevated intracranial pressure (ICP) has not been reported to be a cause of SSS. We present a case of a 55-year-old male that developed SSS after surgical resection of a brain tumor. We have investigated the causal relationship between increased ICP and SSS. We have concluded that elevated ICP creates a sympathovagal imbalance leading to SSS.

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Section: Discussionmentioning

confidence: 99%

Elevated Intracranial Pressure as a Cause of Sick Sinus Syndrome

Makhaly

Fallah

Giannetti

2018

Case Reports in Cardiology

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“…Overall, a high degree of coordination is required between all these different cell types to ensure normal stability of cardiac rhythm and rate. One manifestation of a primary disturbance in cardiac pacemaker function is the so called "sick sinus syndrome" (SSS) [255].…”

Section: Composition Of the Cardiac Conduction Systemmentioning

confidence: 99%

“…SSS, or sinoatrial disease, refers to a chronic clinical syndrome reflecting SAN dysfunction which has a variety of causes [255]. It results in a variety of abnormalities, including sinus bradycardia, sinus pauses, sinus arrest and sinoatrial exit block and may result in chronotropic incompetence, i.e.…”

Section: Manifestations Of Sick Sinus Syndromementioning

confidence: 99%

“…insufficient augmentation of heart rate to meet physiological requirements during exercise or other stress [256]. In up to half of cases, SSS may be accompanied by paroxysmal atrial tachycardia and AVN conduction disturbance, as part of the tachycardiabradycardia syndrome [255][256][257][258][259]. The rhythm disturbances can result in a variety of symptoms, including palpitations, lightheadedness, shortness of breath, exercise intolerance, fatigue and frank syncope [255].…”

Section: Manifestations Of Sick Sinus Syndromementioning

confidence: 99%

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(Re-)programming of subtype specific cardiomyocytes

Hausburg

Jung

Wolfien

et al. 2017

Advanced Drug Delivery Reviews

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Adult cardiomyocytes (CMs) possess a highly restricted intrinsic regenerative potential - a major barrier to the effective treatment of a range of chronic degenerative cardiac disorders characterized by cellular loss and/or irreversible dysfunction and which underlies the majority of deaths in developed countries. Both stem cell programming and direct cell reprogramming hold promise as novel, potentially curative approaches to address this therapeutic challenge. The advent of induced pluripotent stem cells (iPSCs) has introduced a second pluripotent stem cell source besides embryonic stem cells (ESCs), enabling even autologous cardiomyocyte production. In addition, the recent achievement of directly reprogramming somatic cells into cardiomyocytes is likely to become of great importance. In either case, different clinical scenarios will require the generation of highly pure, specific cardiac cellular-subtypes. In this review, we discuss these themes as related to the cardiovascular stem cell and programming field, including a focus on the emergent topic of pacemaker cell generation for the development of biological pacemakers and in vitro drug testing.

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“…The number of cardiac pacemaker implantation procedures is currently increasing secondary to the aging of the global population [1]. Elderly patients often develop degenerative diseases like sick sinus syndrome or atrioventricular block, which are able to cause severe symptoms: syncope, heart failure [2].…”

Section: Introductionmentioning

confidence: 99%

The effect of cardiac pacemaker implantation on cardiac performance – the experience of a Cardiology – Rehabilitation Department

Caloian¹,

Gușetu²,

Costea³

et al. 2018

Balneo

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Background. Although cardiac pacemakers can prevent the occurrence of heart failure secondary to low cardiac output in patients suffering from extreme bradycardia, they can also induce, in some circumstances, heart failure by decreasing the left ventricular stroke volume. In our study, we aim to describe the effect of permanent cardiac pacing on the evolution of patients with heart failure, objectively determined by the N-terminal pro b-type natriuretic peptide (NT-proBNP) dynamics. Material and methods. Complete clinical examination and determination of NT-proBNP were performed before and 5 days after pacemaker implantation. Results. We enrolled in our study 32 patients with an indication for permanent cardiac pacing in which we implanted 21 single-chamber ventricular pacemakers (VVI, 65.6%), 4 single-chamber atrial pacemakers (AAI, 12.5%) and 7 dual-chamber atrio-ventricular pacemakers (DDD, 21.9%). Patients with heart failure had an average NT-proBNP value of 2542.2±2311.12 pg/mL and patients without heart failure (control group), had an average NT-proBNP value of 190.58±98.16pg/mL. Patients in sinus rhythm that received a VVI pacemaker experienced an increase in NT-proBNP values of 103.73%, while patients in atrial fibrillation and VVI of only 0.27%. NT-proBNP values decreased in patients in sinus rhythm that received a DDD or AAI pacemaker by 20.94%. Conclusion. Permanent cardiac pacemakers are able to influence the clinical status of patients with heart failure, especially if they cause the loss of atrio-ventricular synchronism.

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Sick Sinus Syndrome

Cited by 12 publications

References 6 publications

Elevated Intracranial Pressure as a Cause of Sick Sinus Syndrome

Elevated Intracranial Pressure as a Cause of Sick Sinus Syndrome

(Re-)programming of subtype specific cardiomyocytes

The effect of cardiac pacemaker implantation on cardiac performance – the experience of a Cardiology – Rehabilitation Department

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