Sick and tired of COVID-19: long haulers and post viral (fatigue) syndromes

Outhoff, Kim

doi:10.36303/sagp.2020.1.4.0041

Cited by 14 publications

(16 citation statements)

References 17 publications

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“…Numerous research groups reported widespread persisting symptoms in COVID-19 patients for up to 6 months after SARS-CoV-2 infection (70,75,(123)(124)(125)(126)(127)(128)(129)(130)(131)(132)(133)(134)(135)(136)(137)(138)(139)(140)(141)(142). They also described practice on the management of post-acute COVID-19 and performed comprehensive analyses of health-related quality of life (70,75,123).…”

Section: Widespread Persistent Symptomsmentioning

confidence: 99%

“…They also described practice on the management of post-acute COVID-19 and performed comprehensive analyses of health-related quality of life (70,75,123). Furthermore, numerous editorials, reviews, news articles, clinical updates, narrative interviews, and focus groups have been published to explore what it is like to live with long-term COVID-19, also trying to emphasize the putative pathophysiology, risk factors, and treatments (124)(125)(126)(127)(128)(129)(130)(131)(132)(133)(134)(135)(136)(137)(138)(139)(140)(141)(142). Two cohort studies on severe/critical COVID-19 patients reported persistent physiological impairment and decrease in quality of life in more than half of the patients at up to 6 months of follow up (77,100).…”

Section: Widespread Persistent Symptomsmentioning

confidence: 99%

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Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data

et al. 2021

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Whilst the entire world is battling the second wave of COVID-19, a substantial proportion of patients who have suffered from the condition in the past months are reporting symptoms that last for months after recovery, i. e., long-term COVID-19 symptoms. We aimed to assess the current evidence on the long-term symptoms in COVID-19 patients. We did a systematic review on PubMed, Web of Science, EMBASE, and Google Scholar from database inception to February 15, 2021, for studies on long-term COVID-19 symptoms. We included all type of papers that reported at least one long-term COVID-19 symptom. We screened studies using a standardized data collection form and pooled data from published studies. Cohort cross-sectional, case-report, cases-series, case-control studies, and review were graded using specific quality assessment tools. Of 11,361 publications found following our initial search we assessed 218 full-text articles, of which 145 met all selection criteria. We found that 20.70% of reports on long-term COVID-19 symptoms were on abnormal lung functions, 24.13% on neurologic complaints and olfactory dysfunctions, and 55.17% on specific widespread symptoms, mainly chronic fatigue, and pain. Despite the relatively high heterogeneity of the reviewed studies, our findings highlighted that a noteworthy proportion of patients who have suffered from SARS-CoV-2 infection present a “post-COVID syndrome.” The multifaceted understanding of all aspects of the COVID-19 pandemic, including these long-term symptoms, will allow us to respond to all the global health challenges, thus paving the way to a stronger public health.

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Section: Widespread Persistent Symptomsmentioning

confidence: 99%

Section: Widespread Persistent Symptomsmentioning

confidence: 99%

Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data

et al. 2021

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“…Patients with co-existing depression or anxiety also suffer from post-COVID fatigue longer than healthy individuals without psychiatric conditions [15,26]. As mentioned above, breathlessness or shortness of breath has been identified as a significant cause of fatigue [27] and is also related to the need for ICU admission and respiratory assistance, comorbid lung conditions, older age, and obesity [28].…”

Section: Fatiguementioning

confidence: 99%

“…There is currently no evidence assessing the potential direct associations between acute COVID-19 severity and fatigue after recovery from COVID-19 [24]. There is also a lack of research on inflammation markers, changes in cell counts, and pro-inflammatory agents with post-COVID-19 fatigue [28]. These are important research areas because central factors such as neurotransmitter levels, inflammation, and intrinsic neuronal excitability might contribute to COVID-19 fatigue [23].…”

Section: Fatiguementioning

confidence: 99%

Health Complications in Patients Recovering from COVID-19: A Narrative Review of Post-COVID Syndrome

Pai

Park

Chen

et al. 2021

JAMMR

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Introduction: Due to the unprecedented health and economic complications resulting from COVID-19, the coronavirus pandemic is currently a leading global health concern. COVID-19 poses significant health risks, life-threatening clinical conditions, and even mortality in affected individuals. Several associated complications have also arisen as a result of COVID-19, including mass hospitalization, the need for invasive ventilation and intensive care unit (ICU) support, delayed recovery from infection, and post-recovery health issues. Furthermore, the pandemic itself has created enormous panic, which in turn affects the mental health of COVID-19 patients, individuals who have recovered from the disease, and the general population. Just over a year has now passed since the beginning of the global COVID-19 pandemic and in this time, over 110 million individuals have been infected worldwide. Post-infection recovery times and long-term complications are now becoming more apparent. Especially physical and mental health complications arising from post-COVID-19-infection, which prevent a return to a healthy lifestyle and everyday routine remain a critical issue. Objective: The primary objective of this narrative review is to address this clinically relevant issue and overview the health complications commonly observed in individuals who have recovered from COVID-19. Methods: An investigation was performed on online databases for relevant articles from 2020 until January 2021. Key index words used in search were post-covid, myalgia, fatigue, pain. Results: Fatigue, myalgia (i.e., muscle pain), sleep disruptions, and mental health issues (e.g., anxiety and depression) are among the most reported post-recovery symptoms in patients recovering from the disease. The etiology and potential management of these health complications are discussed, considering recently published findings from COVID-19 patients as well as previous studies focusing on complications arising from other related pandemics. Conclusion: Patients who have recovered from COVID-19 should be evaluated for signs of fatigue, muscle pain, mental health difficulties, and sleeping difficulties regardless of disease severity. Based on this review of the literature, complete clinical and psychiatric evaluation, and the use of validated indicators of the severity of COVID-19 disease, symptoms are recommended to develop efficient health management approaches that meet patients' needs.

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“…Although in some cases COVID-19 patients were asymptomatic, many people complained from pneumonia, cough, fever, and gastrointestinal [GI] problems [ 2 , 3 ]. Recently, the long haul COVID-19 illness started to gain recognition whereby some patients suffer from symptoms in the long term even when their viral tests were confirmed negative [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

TRP channels in COVID-19 disease: Potential targets for prevention and treatment

Jaffal

Abbas

2021

Chemico-Biological Interactions

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Coronavirus disease 2019 [COVID-19] is a global health threat caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV2] that requires two proteins for entry: angiotensin-converting enzyme 2 [ACE2] and trans-membrane protease serine 2 [TMPRSS2]. Many patients complain from pneumonia, cough, fever, and gastrointestinal (GI) problems. Notably, different TRP channels are expressed in various tissues infected by SARS-CoV-2. TRP channels are cation channels that show a common architecture with high permeability to calcium [Ca 2+ ] in most sub-families. Literature review shed the light on the possible role of TRP channels in COVID-19 disease. TRP channels may take part in inflammation, pain, fever, anosmia, ageusia, respiratory, cardiovascular, GI and neurological complications related to COVID-19. Also, TRP channels could be the targets for many active compounds that showed effectiveness against SARS-CoV-2. Desensitization or blocking of TRP channels by antibodies, aptamers, small molecules or venoms can be an option for COVID-19 prevention and future treatment. This review provides insights into the involvement of TRP channels in different symptoms and mechanisms of COVID-19, potential treatments targeting these channels and highlights missing gaps in literature.

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Sick and tired of COVID-19: long haulers and post viral (fatigue) syndromes

Cited by 14 publications

References 17 publications

Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data

Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data

Health Complications in Patients Recovering from COVID-19: A Narrative Review of Post-COVID Syndrome

TRP channels in COVID-19 disease: Potential targets for prevention and treatment

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