Sicca Symptoms in Parkinson’s Disease: Association with Other Nonmotor Symptoms and Health-Related Quality of Life

Prell, Tino; Schaller, Denise; Perner, Caroline; Witte, Otto W.; Großkreutz, Julian

doi:10.1155/2020/2958635

Cited by 8 publications

(11 citation statements)

References 32 publications

(40 reference statements)

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“…In the last decade, the influence of non-motor symptoms was extensively studied [ 41 ]. However, even during the last few years, several neglected non-motor symptoms have emerged or found new spotlights [ 26 , 40 , 42 ]. Our results support the role of alexithymia as a non-motor symptom contributing to impaired quality of life in PD.…”

Section: Discussionmentioning

confidence: 99%

Alexithymia Is Associated with Reduced Quality of Life and Increased Caregiver Burden in Parkinson’s Disease

et al. 2020

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Parkinson’s disease (PD) is the second most frequent neurodegenerative disease of people who are beyond 50 years of age. People with PD (PwP) suffer from a large variety of motor and non-motor symptoms resulting in reduced health-related quality of life (HR-QoL). In the last two decades, alexithymia was identified as an additional non-motor symptom in PD. Alexithymia is defined as a cognitive affective disturbance resulting in difficulty to identify and distinguish feelings from bodily sensations of emotional arousal. In PD, the frequency of patients suffering of alexithymia is increased compared to healthy controls. The aim of the present study was to determine the relationship of alexithymia to HR-QoL of the PwP and caregiver burden of the corresponding caregiver. This cross-sectional questionnaire-based study used disease specific questionnaires for HR-QoL and caregiver burden. In total 119 PwP and their corresponding caregivers were included in the study. HR-QoL of the PwP correlated significantly with alexithymia (p < 0.001), especially the sub-components “identifying feelings” (p < 0.001) and “difficulties describing feelings” (p = 0.001). Caregiver burden also correlated significantly with PwP alexithymia (p < 0.001). However, caregiver burden was associated with sub-components “identifying feelings” (p < 0.008) and “external oriented thinking” (p < 0.004). These data support the importance of alexithymia as a non-motor symptom in PD.

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Section: Discussionmentioning

confidence: 99%

Alexithymia Is Associated with Reduced Quality of Life and Increased Caregiver Burden in Parkinson’s Disease

et al. 2020

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“…However, in another study, 50% of the PD patients were reported to have xerostomia accompanied by hyposalivation [ 22 ]. It was reported by other researchers that an even higher prevalence of 69% PD patients had sicca symptoms (xerostomia and dry eyes), which might be caused by anti-PD medications or antidepressant drugs [ 23 ]. Our study showed that 59.14% of the total PD patients had dry mouth, 57.89% in M-PD and 60.44% in FM-PD, respectively, in accordance with other reports.…”

Section: Discussionmentioning

confidence: 99%

“…However, there was no significant difference between men and women. Dry mouth contributes to both caries and periodontal disease, influences not only oral health but also general health-related quality of life (QoL), and is thought to be closely associated with malnutrition in PD patients [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Gender Was Associated with Depression but Not with Gastrointestinal Dysfunction in Patients with Parkinson’s Disease

Qin

Liu

et al. 2021

Parkinson's Disease

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Objective. To investigate the association between gender and gastrointestinal (GI) dysfunctions, as well as gender and other motor symptoms/nonmotor symptoms, in a sample of PD patients. Methods. 186 patients with PD were recruited into this study and divided into male PD group (M-PD) and female PD group (FM-PD). Demographic and PD-related clinical information of the participants were collected by the same neurologist. PD patients were objectively assessed by a spectrum of rating scales of motor symptoms and nonmotor symptoms (including GI dysfunctions). The data were analyzed by SPSS 20 statistical software. Results. Totally 95 cases (51.08%) were in the M-PD group and 91 cases (48.92%) in the FM-PD group. There were no significant differences in age, BMI, and lifestyles between the two groups (P > 0.05). Males had higher educational level (P = 0.002). Females were more likely to have early satiety and loss of appetite (P = 0.025, P = 0.001). There were no significant differences in LED disease duration, age of motor symptoms onset, types of motor symptoms onset, location of motor symptoms onset, and phenotype of motor symptoms between the two groups (P > 0.05). Females had significantly higher UPDRS-III and HAMD scores than males (P = 0.037, P = 0.034). There were no significant differences in PQSI, ESS, RLS, RBD, HAMA, HAMD, and MoCA scores between the two groups. Gender was associated with HAMD (OR = 0.682, P = 0.019). Conclusions. Gender is a risk factor for depression, but not for GI dysfunctions in patients with PD.

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“…Cardiovascular alterations can affect approximately 80% of PD patients and can worsen the progression of the disease, increasing the risk of death [17,29,65]. The most frequent clinical manifestation of cardiac autonomic failure in PD is OH [66].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…Therefore, it is suggested that both cardiac sympathetic denervation and parasympathetic dysfunction can occur concurrently [16]. Cardiovascular disorders have been detected in approximately 80% of PD patients [17], with OH being the most common cardiac-related autonomic dysfunction (30-40% of cases) [15]. Investigating the cardiac condition in PD could provide a more accurate (and earlier) in vivo diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Cardiac Changes in Parkinson’s Disease: Lessons from Clinical and Experimental Evidence

Cuenca‐Bermejo

Almela

Navarro‐Zaragoza

et al. 2021

IJMS

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Dysautonomia is a common non-motor symptom in Parkinson’s disease (PD). Most dysautonomic symptoms appear due to alterations in the peripheral nerves of the autonomic nervous system, including both the sympathetic and parasympathetic nervous systems. The degeneration of sympathetic nerve fibers and neurons leads to cardiovascular dysfunction, which is highly prevalent in PD patients. Cardiac alterations such as orthostatic hypotension, heart rate variability, modifications in cardiogram parameters and baroreflex dysfunction can appear in both the early and late stages of PD, worsening as the disease progresses. In PD patients it is generally found that parasympathetic activity is decreased, while sympathetic activity is increased. This situation gives rise to an imbalance of both tonicities which might, in turn, promote a higher risk of cardiac damage through tachycardia and vasoconstriction. Cardiovascular abnormalities can also appear as a side effect of PD treatment: L-DOPA can decrease blood pressure and aggravate orthostatic hypotension as a result of a negative inotropic effect on the heart. This unwanted side effect limits the therapeutic use of L-DOPA in geriatric patients with PD and can contribute to the number of hospital admissions. Therefore, it is essential to define the cardiac features related to PD for the monitorization of the heart condition in parkinsonian individuals. This information can allow the application of intervention strategies to improve the course of the disease and the proposition of new alternatives for its treatment to eliminate or reverse the motor and non-motor symptoms, especially in geriatric patients.

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Sicca Symptoms in Parkinson’s Disease: Association with Other Nonmotor Symptoms and Health-Related Quality of Life

Cited by 8 publications

References 32 publications

Alexithymia Is Associated with Reduced Quality of Life and Increased Caregiver Burden in Parkinson’s Disease

Alexithymia Is Associated with Reduced Quality of Life and Increased Caregiver Burden in Parkinson’s Disease

Gender Was Associated with Depression but Not with Gastrointestinal Dysfunction in Patients with Parkinson’s Disease

Cardiac Changes in Parkinson’s Disease: Lessons from Clinical and Experimental Evidence

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