Context
Polycystic ovary syndrome (PCOS) is a prevalent hormonal imbalance that predominantly affects women in their reproductive years. Previous studies have yielded conflicting conclusions.
Objective
This is an updated meta-analysis aiming to explore the connection between flavonoid supplementation and PCOS.
Data Sources
Seven databases were searched: Cochrane Library, PubMed, Web of Science, Embase, Wanfang, China Science and Technology Journal, and China National Knowledge Infrastructure, spanning from their inception to April 15, 2024.
Data Extraction
Two authors independently searched the databases using the search terms.
Data Analysis
Following strict inclusion criteria, 8 papers were ultimately included. This updated meta-analysis suggests that flavonoid supplementation could enhance follicular development, promote the proliferation and differentiation of follicular granulosa cells, elevate estradiol levels, and mitigate testosterone, C-reactive protein, and ovarian index levels.
Conclusion
This analysis suggests that dietary flavonoids could potentially alleviate symptoms associated with PCOS.
Systematic Review Registration
PROSPERO registration no. CRD42022382912.