“…[11][12][13][14]18,28 Despite its effectiveness in losing weight, several side effects have been reported, including cardiac arrhythmia, myocardial infarction, cardiomyopathy and high blood pressure. 10,29 Previous studies conducted in our laboratory reported lower sperm quality and fertility in rats exposed for 30 days to sibutramine during the light phase of the l/d cycle. 2,3 In the present study, we aimed to investigate whether a change in the timing of drug administration, that is during the dark phase of l/d cycle, when rodents have higher metabolic activity and increased availability of norepinephrine, 22 would change these deleterious effects on reproduction.…”