Abstract:Metabolic glycoengineering involves the stimulation of
cells with
functionalized monosaccharides. Glucosamine, galactosamine, and mannosamine
derivatives are commercially available, but their application may
lead to undirected (i.e., chemical) incorporation into proteins. However,
sialic acids are attached to the ends of complex sugar chains of glycoproteins,
which might be beneficial for cell surface modification via click
chemistry. Thus, we studied the incorporation of chemically synthesized
unnatural alkyn… Show more
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