Sialylated glycoproteins as biomarkers and drivers of progression in prostate cancer

Wen, Ru; Zhao, Huihui; Zhang, Dalin; Chiu, Chun Lung; Brooks, James D.

doi:10.1016/j.carres.2022.108598

Cited by 11 publications

(4 citation statements)

References 130 publications

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“…The emerging research on sialic acids underscores their role in cancer initiation, progression, and immune evasion, highlighting the broader biological significance of sialylation. 41,42 The phenomenon of hypersialylation in cancer cells, resulting from increased metabolic flux of sialic acids and dysregulated enzyme expression, seems to align well with the investigation into transferrin sialylation reported herein. This relationship is particularly relevant, considering that alterations in sialic acid content on transferrin impact its primary function as an iron carrier with potential consequences in cellular management of oxidative stress associated with cancer or ferroptosis.…”

Section: Dalton Transactions Papersupporting

confidence: 81%

Protein sialylation affects the pH-dependent binding of ferric ion to human serum transferrin

Friganović,

Borko,

Weitner

2024

Dalton Trans.

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Section: Dalton Transactions Papersupporting

confidence: 81%

Protein sialylation affects the pH-dependent binding of ferric ion to human serum transferrin

Friganović,

Borko,

Weitner

2024

Dalton Trans.

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“…The lectin WGA (wheat germ agglutinin from Triticum Vulgaris ) interacts with the sialylated glycoproteins but may also bind to N-Acetyl-D-glucosamine (GlcNAc) [71]. Sialylated glycoproteins have already been reported to be a potential biomarker as they may drive cancer progression, as shown for prostate [72], breast [73], or ovarian [74] cancers.…”

Section: Discussionmentioning

confidence: 99%

Migration, proliferation, and elasticity of bladder cancer cells on lectin-coated surfaces

Luty,

Szydlak,

Pabijan

et al. 2024

Preprint

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The alterations in migration, proliferation, and mechanics of cells observed during cancer progression can potentially be linked to enhanced tumor invasiveness. These properties are frequently attributed to the ability to form distant metastasis; however, the direct mutual connection between these properties is not always proven. Here, we studied the migratory, proliferative, and mechanical phenotype of three bladder cancer cells originating from various stages of cancer progression, i.e., non-malignant cell cancer of ureter (HCV29 cells), bladder carcinoma (HT1376 cells) and transitional bladder carcinoma (T24 cells). The results were linked with the organization of actin filaments because of their major role in cell migration. The results classified cells into non-malignant, non-invasive, and invasive, revealing the significant impact of actin filaments in bladder cancer invasion. Based on the reported changes in cancer cell glycosylation, the potential applicability of the observed cancer-related changes to identify invasive cells was demonstrated for the lectin-coated surfaces, which is the potential surface modification for biosensors.

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“…Additionally, the Siglec receptor and E-selectin, which are typically overexpressed on the surface of tumor cell membranes, can selectively bind sialic acid. [32][33][34] Thus, SA-modified preparations exhibit superior tumor-targeting ability and suppress immune cell phagocytosis of the preparation. [35][36][37][38] In this study, we first validated the synergistic antitumor effect of triclabendazole and decitabine.…”

Section: Introductionmentioning

confidence: 99%

Sialic Acid‐Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy

Hu,

You,

Zhu

et al. 2023

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The efficacy of immune checkpoint blockade (ICB) in promoting an immune response against tumors still encounters challenges such as low response rates and off‐target effects. Pyroptosis, an immunogenic cell death (ICD) mechanism, holds the potential to overcome the limitations of ICB by activating and recruiting immune cells. However, the expression of the pyroptosis‐related protein Gasdermin‐E(GSDME) in some tumors is limited due to mRNA methylation. To overcome this obstacle, sialic acid‐functionalized liposomes coloaded with decitabine, a demethylation drug, and triclabendazole, a pyroptosis‐inducing drug are developed. This nanosystem primarily accumulates at tumor sites via sialic acid and the Siglec receptor, elevating liposome accumulation in tumors up to 3.84‐fold at 24 h and leading to the upregulation of pyroptosis‐related proteins and caspase‐3/GSDME‐dependent pyroptosis. Consequently, it facilitates the infiltration of CD8+ T cells into the tumor microenvironment and enhances the efficacy of ICB therapy. The tumor inhibition rate of the treatment group is 89.1% at 21 days. This study highlights the potential of sialic acid‐functionalized pyroptosis nanotuners as a promising approach for improving the efficacy of ICB therapy in tumors with low GSDME expression through epigenetic alteration and ICD.

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Sialylated glycoproteins as biomarkers and drivers of progression in prostate cancer

Cited by 11 publications

References 130 publications

Protein sialylation affects the pH-dependent binding of ferric ion to human serum transferrin

Protein sialylation affects the pH-dependent binding of ferric ion to human serum transferrin

Migration, proliferation, and elasticity of bladder cancer cells on lectin-coated surfaces

Sialic Acid‐Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy

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