Sialorrhea in children with cerebral palsy

Dias, Bruno Leonardo Scofano; Fernandes, Alexandre Ribeiro; Filho, Heber de Souza Maia

doi:10.1016/j.jpedp.2016.06.002

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…It can also impact a child socially. The salivary glands typically targeted for BoNT injections are the submandibular glands, as they secrete more saliva at baseline, and the parotid glands, as they secrete more saliva with stimulation 179 . Currently IncoA (approved in 2018) and RimB (approved in 2019) are the only two BoNTs that are FDA approved for the treatment of sialorrhea.…”

Section: Clinical Indicationsmentioning

confidence: 99%

See 1 more Smart Citation

A consensus statement on the use of botulinum toxin in pediatric patients

Vova

Green

Brandenburg

et al. 2021

PM&R

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Botulinum toxin has been used in medicine for the past 30 years. However, there continues to be controversy about the appropriate uses and dosing, especially in the pediatric population. A panel of nine pediatric physiatrists from different regions and previous training programs in the United States were nominated based on institutional reputation and botulinum toxin (BoNT) experience. Based on a review of the current literature, the goal was to provide the rationale for recommendations on the administration of BoNT in the pediatric population. The goal was not only to review safety, dosing, and injection techniques but also to develop a consensus on the appropriate uses in the pediatric population. In addition to upper and lower limb spasticity, the consensus also provides recommendations for congenital muscular torticollis, cervical dystonia, sialorrhea, and brachial plexus palsies.

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Section: Clinical Indicationsmentioning

confidence: 99%

“…Sialorrhea (drooling) is commonly seen in children with central nervous system disorders. In children with the most common movement disorder of childhood, CP, 10% to 58% have sialorrhea 179,180 . Sialorrhea can lead to perioral skin irritation, articulation difficulties, aspiration, and progressive respiratory morbidity 181,182 .…”

Section: Clinical Indicationsmentioning

confidence: 99%

A consensus statement on the use of botulinum toxin in pediatric patients

Vova

Green

Brandenburg

et al. 2021

PM&R

View full text Add to dashboard Cite

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The impact of botulinum toxin type A in the treatment of drooling in children with cerebral palsy secondary to Congenital Zika Syndrome: an observational study

Sales

Cerqueira

Vaz

et al. 2020

Neurological Research

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Objective:The main aim of this study was to determine the impact of botulinum toxin A (BTX-A) on severity and frequency of drooling in children with Cerebral Palsy (CP) secondary to Congenital Zika Syndrome (CZS). Methods: This is a prospective longitudinal observational study including 23 children who received bilateral injections of BTX in the parotid and submandibular glands. The Thomas-Stonell & Greenberg Drooling Severity and Frequency Scale was applied by a multidisciplinary team including Speech, Language and Hearing professionals. The Global Impression of Improvement (GII) Scale was also applied to assess parents' subjective perceptions of therapeutic response. Swallowing was assessed using Doppler ultrasonography. Univariate logistic regression was used to analyse differences between responders and non-responders. Results: Participant age varied from 27 to 38 months (mean 31.78, SD = 2.61) all presented with Gross Motor Function Classification System (GMFCS) V. Drooling Severity and Frequency Scale scores ranged from 7 to 9 points (median = 9) prior to BTX administration and from 4 to 6 (median = 6) after. Pre-and post-treatment reduction in drooling severity occurred (Z = −3.746; p < 0.001). No cases of drooling worsening were reported. Only two subjects presented adverse effects attributed to BTX administration. Correlation was only confirmed with GII. Discussion: This article presents the safe and positive impact of BTX-A administration guided by anatomical references described in the literature, even on children with microcephaly. Further studies are needed to facilitate the use of Doppler ultrasonography as a tool to characterize changes in sensory processing and motor response following intraoral input in children with CP.

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Spasti̇k Ve Di̇ski̇neti̇k Ti̇p Serebral Palsi̇li̇ Çocuklarda Salya Kontrol Problemi̇ni̇n Ve Sali̇vasyonun İncelenmesi̇

Şipal¹

2018

Türk Fizyoterapi Ve Rehabilitasyon Dergisi

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Bu çalışmanın amacı, spastik ve diskinetik tip serebral palsili (SP) çocuklarda oromotor özelliklerin ve eşlik eden faktörlerin salivasyona etkisini incelemekti. Yöntem: Çalışmamıza 20 SP'li çocuk (SP Grubu) ve 10 sağlıklı çocuk (kontrol grubu) dâhil edildi. Ana çalışma grupları; SP(+) (salya kontrol problemi olan SP'li çocuklar) ve SP(-) (salya kontrol problemi olmayan SP'li çocuklar) şeklinde isimlendirildi ve bu gruplarda 10'ar kişi yer aldı. Alt gruplar, beşer kişiden oluşmak üzere S(+) (salya kontrol problemi olan spastik SP'li çocuklar), S(-) (salya kontrol problemi olmayan spastik SP'li çocuklar), D(+) (salya kontrol problemi olan diskinetik SP'li çocuklar) ve D(-) (salya kontrol problemi olmayan diskinetik SP'li çocuklar) olarak ayrıldı. Tüm olgulara Kaba Motor Fonksiyon Sınıflama Sistemi (GMFCS), Salya Kontrol Problemi Şiddet ve Sıklık Skalası (DSFS), salya akış oranı tespiti için sünger testi, Yutma Yeteneği ve Fonksiyonu Değerlendirmesi (SAFE) ve Pediatrik Özürlülük Değerlendirmesi (PEDI) uygulandı. Sonuçlar: Salya akış oranları bakımından gruplar arasında anlamlı bir fark bulunmadı (p>0,05). SAFE düzeyleri, GMFCS düzeyleri ve PEDI puanları bakımından, salya kontrol problemi olmayanların lehine gruplar arasında istatistiksel olarak anlamlı fark bulundu (p<0,05). Ölçülen parametrelerin salya akış oranları ile arasında anlamlı bir ilişki bulunmadı (p>0,05). Tartışma: Spastik ve diskinetik tip SP'li çocuklarda oral motor özellikler saliva akış oranlarına etki etmezken, orofarengeal yutma becerilerinin salya kontrolü üzerinde önemli olduğu görüldü. Salya kontrol problemi olan çocuklar günlük yaşam becerilerinde daha çok zorlanmaktaydı.

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Sialorrhea in children with cerebral palsy

Cited by 3 publications

References 56 publications

A consensus statement on the use of botulinum toxin in pediatric patients

A consensus statement on the use of botulinum toxin in pediatric patients

The impact of botulinum toxin type A in the treatment of drooling in children with cerebral palsy secondary to Congenital Zika Syndrome: an observational study

Spasti̇k Ve Di̇ski̇neti̇k Ti̇p Serebral Palsi̇li̇ Çocuklarda Salya Kontrol Problemi̇ni̇n Ve Sali̇vasyonun İncelenmesi̇

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