Sialoblastoma in cheek region: Report of a case

Karaman, Emin; Duman, Cihan; Cansız, Harun; Yıldız, İsmail; Dervışoğlu, Sergülen; Özdemir, Gül Nihal

doi:10.1016/j.pedex.2009.01.007

Cited by 3 publications

(6 citation statements)

References 12 publications

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“…Due to the limited number of the cases, definitive treatment guidelines have not yet been established ( 7 , 9 ). Early complete surgical excision remains the cornerstone of the surgical management of sialoblastoma ( 2 , 7 , 9 , 15 ), whereas radiotherapy and chemotherapy remain controversial ( 15 ). Radiation may play a role in cases with incomplete tumor resection ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, since the disease mostly occurs in childhood, the use of radiotherapy may be limited, due to the radiation-related side effects, such as impaired bone growth, abnormal facial structure and mutagenic effects ( 8 , 9 ). Sialoblastoma is likely sensitive to chemotherapy ( 9 ), which may be useful in patients with extensive or metastatic tumors, relapsed cases, or inadequate surgical excision of a primary tumor ( 1 , 7 , 9 , 15 ). The protocols are usually based on the chemosensitivity, as with other mesenchymal tumors ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

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Sialoblastoma of the cheek: A case report and review of the literature

Sitthichaiyakul

Somran

Oilmungmool

et al. 2016

Molecular and Clinical Oncology

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Sialoblastoma is a rare salivary gland tumor that recapitulates the primitive salivary gland anlage. The authors herein report a case of sialoblastoma of a minor salivary gland, clinically presenting with progressive enlargement of a mass in the cheek of a 1-year-old female infant. Histopathologically, the mass consisted of tight clusters of basaloid cells and partially formed ductal and pseudo-ductal spaces separated by thin fibrous bands. Immunohistchemical studies demonstrated the presence of cytokeratin AE1/AE3, p63, CD99, α-fetoprotein (AFP) and Hep Par-1 expression in a considerable number of tumor cells. The clinical and pathological characteristics are presented and relevant literature is reviewed. Early complete surgical excision is recommended for the treatment of sialoblastoma. Radiation may be considered in cases with incomplete resection of the tumor. Chemotherapy may play a vital role in extensive, metastatic, or relapsed cases, or in cases with inadequate excision. The follow-up treatment should be frequent and prolonged. To the best of our knowledge, this is the first reported case of sialoblastoma of the cheek with immunoreactivity for AFP and Hep Par-1, which may be associated with the embryonic origin of the tumor. AFP may be a useful marker of tumor response in patient with sialoblastoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sialoblastoma of the cheek: A case report and review of the literature

Sitthichaiyakul

Somran

Oilmungmool

et al. 2016

Molecular and Clinical Oncology

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“…In the screening phase, 103 articles were selected for full‐text evaluation. Of these, 51 selected studies 3,5,7–10,13–57 met the eligibility criteria. Additionally, 1 article 58 was added from a manual search of the reference lists of included studies, resulting in the inclusion of 52 articles in the qualitative synthesis.…”

Section: Resultsmentioning

confidence: 99%

“…Sialoblastomas are clinically nonspecific, and their clinical appearance may overlap with other lesions of higher incidence 10 . The differential diagnosis included other neoplasms of glandular origin, 27 vascular lesions, 45 and infectious diseases 40 . According to Mariz et al, 66 symptomatic lesions, color change and presence of telangiectasia may be predictors of malignancy for palatine salivary gland tumors.…”

Section: Discussionmentioning

confidence: 99%

“…10 The differential diagnosis included other neoplasms of glandular origin, 27 vascular lesions, 45 and infectious diseases. 40 According to Mariz et al, 66 symptomatic lesions, color change and presence of telangiectasia may be predictors of malignancy for palatine salivary gland tumors. Although the intraoral presentation of sialoblastoma is nonspecific, such features may be useful to support the decision to perform an incisional or excisional biopsy, even in lesions located in extraoral sites.…”

Section: Variablesmentioning

confidence: 99%

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Clinicopathological study and survival outcomes of sialoblastoma: A systematic review

et al. 2023

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Sialoblastoma is a rare malignant salivary gland tumor. The aim of this study was to review the available published data on sialoblastoma in a comprehensive analysis of its clinicopathologic characteristics, treatment, and outcomes. An unrestricted electronic search was performed in the following databases: MEDLINE/PubMed, EMBASE, Scopus, Web of science, and gray literature databases. Eligibility criteria included publications with sufficient clinical, imaging, and histopathological information to confirm the diagnosis of sialoblastoma. Data were evaluated descriptively and analytically. A total of 52 studies met the eligibility criteria. In total, 62 patients were evaluated. There was no gender predilection, with the parotid being the most affected primary site (n = 28; 45.2%). In the log‐rank test, there was a significant increase in disease‐associated survival in patients younger than 1 year of age (82.8% vs. 44.4%; p = 0.003), individuals with lesions in major salivary glands (79.4% vs. 38.5%; p = 0.005), patients without metastases (77.8% vs. 14.3%; p = 0.011), encapsulated lesions (85.7% vs. 0%; p < 0.0001), congenital lesions (83.3% vs. 25.0%; p < 0.0001), and lesions that do not show perineural invasion (89.5% vs. 40%; p = 0.035). Kaplan–Meier curves estimated overall survival and disease‐free survival at 5 years of 95.5% and 68.1%, respectively. In the multivariate Cox regression model, only the presence of metastasis was identified as an independent prognostic factor (hazard ratio [HR] = 9.81; p = 0.010). Although sialoblastoma presents good prognosis, the tumor has a high recurrence rate.

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Sialoblastoma in chin and management of treatment

Wang

Chen

et al. 2018

International Journal of Pediatric Otorhinolaryngology

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Sialoblastoma in cheek region: Report of a case

Cited by 3 publications

References 12 publications

Sialoblastoma of the cheek: A case report and review of the literature

Sialoblastoma of the cheek: A case report and review of the literature

Clinicopathological study and survival outcomes of sialoblastoma: A systematic review

Sialoblastoma in chin and management of treatment

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