Sialic Acid in Biochemical Pathology

Suzuki, Kunihiro

doi:10.1007/978-1-4757-9504-2_10

Cited by 7 publications

(5 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Certain diseases and pregnancy [39] are characterized by both increased incidence and diversity of sialyloligosaccharides. Salla's disease is a defective lysosomal membrane transport system for SA, in which the level of free SA in urine is about 5-to 10-fold compared with normal [42]. Sewell et al [43] have showed an increased urinary excretion of free SA and confirmed this in cultivated fibroblasts.…”

Section: Urinementioning

confidence: 99%

“…In sialuria, a rare defect with excessive synthesis of SA, free ᮊ 1999 Blackwell Science Ltd, European Journal of Clinical Investigation, 29, 413-425 Table 2 Mean Ϯ SD, serum total SA (TSA), lipid-bound SA (LSA), TSA/total protein (TP) and protein-bound SA (PBSA) levels in healthy humans SA levels can be elevated 70-to 200-fold [44,45]. Sialidosis refers to a series of disorders caused by genetic abnormalities in the lysosomal sialidase, which removes the terminal SA from glycoproteins [42]. Several SA-containing glycoproteins originating from plasma are found in urine.…”

Section: Urinementioning

confidence: 99%

See 1 more Smart Citation

Occurrence of sialic acids in healthy humans and different disorders

Sillanaukee

Pönniö

Jä̈askëlainen

1999

Eur J Clin Investigation

226

166

View full text Add to dashboard Cite

Sialic acid (SA), N-acetylated derivatives of neuraminic acid, play a central role in the biomedical functioning of humans. The normal range of total sialic acid (TSA) level in serum/plasma is 1.58-2.22 mmol L-1, the free form of SA only constituting 0.5-3 mumol L-1 and the lipid-associated (LSA) forms 10-50 mumol L-1. Notably, considerably higher amounts of free SA are found in urine than in serum/plasma (approximately 50% of the total SA). In inherited SA storage diseases such as Salla's disease, SA levels are elevated many times over, and their determination during clinical investigation is well established. Furthermore, a number of reports describe elevated SA levels in various other diseases, tentatively suggesting broader clinical utility for SA markers. Increased SA concentrations have been reported during inflammatory processes, probably resulting from increased levels of richly sialylated acute-phase glycoproteins. A connection between increased SA levels and elevated stroke and cardiovascular mortality risk has also been reported. In addition, SA levels are slightly increased in cancer, positively correlating with the degree of metastasis, as well as in alcohol abuse, diabetes, chronic renal failure and chronic glomerulonephritis. Several different mechanisms are assumed to underlie the elevated SA concentrations in these disorders. The apparent non-specificity of SA to a given disease limits the potential clinical usefulness of SA determination. In addition, some non-pathological factors, such as aging, pregnancy and smoking, may cause changes in SA concentrations. The absolute increases in SA levels are also rather small (save those in inherited SA storage disorders); this further limits the clinical potential of SA as a marker. Tentatively, SA markers might serve as adjuncts, when combined with other markers, in disease screening, disease progression follow-up, and in the monitoring of treatment response. To become clinically useful, however, the existing SA determination assays need to be considerably refined to reduce interferences, to be specific for certain SA forms, and to be more easy to use.

show abstract

Section: Urinementioning

confidence: 99%

Section: Urinementioning

confidence: 99%

Occurrence of sialic acids in healthy humans and different disorders

Sillanaukee

Pönniö

Jä̈askëlainen

1999

Eur J Clin Investigation

226

166

View full text Add to dashboard Cite

show abstract

“…For the measurement of serum total SA level, Denny's colorimetric method was used (18) . This method is the modified version of Aminoff and Warren methods, which are thiobarbituric acid (TBA) colorimetric assays that are commonly used for the measurement of total SA level (19,20) .…”

Section: Methodsmentioning

confidence: 99%

Serum Total Sialic Acid Levels And Sialic Acid Acetyl Esterase Gene Variation In Patients With Preeclampsia

Gül¹,

Öztürk²,

Uğur³

et al. 2012

J Turk Soc Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…So far, about 150 cases have been reported. 1141,1145 The name "Salla" is derived from a Northern area in Finland from where most of the patients originated. However, two patients with Salla disease were also detected in Turkey.…”

Section: Salla Disease and Infantile Sialic Acid Storage Diseasementioning

confidence: 99%

Exploration of the Sialic Acid World

Schauer

Kamerling

2018

Advances in Carbohydrate Chemistry and Biochemistry

252

225

View full text Add to dashboard Cite

The Sialic Acid World Table 1 Survey of Reported Structures of Naturally Occurring Members of the Sialic Acid Family-cont'd Name Abbreviation References5-N-Acetyl-8-O-acetyl-9-Olactyl-neuraminic acid Neu5,8Ac 2 9Lt 45 5-N-Acetyl-8-O-methylneuraminic acid Neu5Ac8Me 6,19,25,33,46 5-N-Acetyl-4-O-acetyl-8-Omethyl-neuraminic acid Neu4,5Ac 2 8Me 19 5-N-Acetyl-9-O-acetyl-8-Omethyl-neuraminic acid Neu5,9Ac 2 8Me 6,19,33,46 5-N-Acetyl-9-O-methylneuraminic acid Neu5Ac9Me 47 5-N-Acetyl-4-O-sulfoneuraminic acid Neu5Ac4S 48 5-N-Acetyl-8-O-sulfoneuraminic acid Neu5Ac8S 19,32,49,50 5-N-Acetyl-4-O-acetyl-8-Osulfo-neuraminic acid Neu4,5Ac 2 8S 19 5-N-Acetyl-9-O-phosphoneuraminic acid f,g Neu5Ac9P 51 5-N-Acetyl-2-deoxy-2,3didehydro-neuraminic acid g,h Neu2en5Ac 6,30,33,43,52-54 5-N-Acetyl-9-O-acetyl-2deoxy-2,3-didehydroneuraminic acid g Neu2en5,9Ac 2 55,56 5-N-Acetyl-2-deoxy-2,3didehydro-9-O-lactylneuraminic acid g Neu2en5Ac9Lt 55,565-N-Acetyl-2,7-anhydroneuraminic acid g,i

show abstract

Sialic Acid in Biochemical Pathology

Cited by 7 publications

References 85 publications

Occurrence of sialic acids in healthy humans and different disorders

Occurrence of sialic acids in healthy humans and different disorders

Serum Total Sialic Acid Levels And Sialic Acid Acetyl Esterase Gene Variation In Patients With Preeclampsia

Exploration of the Sialic Acid World

Contact Info

Product

Resources

About