Sialic Acid-Functionalized Gold Nanoparticles for Sensitive and Selective Colorimetric Determination of Serotonin
Begüm Avcı,
Yeliz Akpınar,
Gülay Ertaş
et al.
Abstract:We present a novel colorimetric method inspired by nature’s
complex mechanisms, capable of selectively determining serotonin with
high sensitivity. This method exploits the inherent binding affinity
of serotonin with sialic acid (SA) molecules anchored to gold nanoparticles
(SA-AuNPs). Upon serotonin binding, SA-AuNPs aggregate, and a characteristic
red shift in the absorbance of SA-AuNPs accompanied by a dramatic
color change (red to blue) occurs, readily observable even without
instrumentation. The proposed … Show more
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