Sialendoscopy in the Management of Radioiodine Induced Sialadenitis: A Systematic Review

Cung, Thai-Duong; Lai, Wanda; Svider, Peter F.; Hanba, Curtis; Samantray, Julie; Folbe, Adam J.; Shkoukani, Mahdi A.; Raza, Syed Mohsin

doi:10.1177/0003489417732795

Cited by 20 publications

(28 citation statements)

References 30 publications

(44 reference statements)

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“…Findings of this present study are confirming data from a recently published systematic review encompassing 122 patients with RAIS, which stated that sialendoscopy can be seen as an effective and minimally (table below). invasive methodology with high success rate, thus potentially reducing the need for more invasive surgical procedures (14).…”

Section: Discussionmentioning

confidence: 99%

“…Xerostomia due to RIT can lead to decreased health-related quality of life (HRQOL) (12,13). Patients not responding to conservative treatments, consisting of medication and sialogogues, may benefit from sialendoscopy procedure (14). Sialendoscopy, in which either the submandibular or parotid duct is cannulated with an endoscope, has been described as a diagnostic and therapeutic modality for different pathologies (14,15).…”

Section: Introductionmentioning

confidence: 99%

“…Patients not responding to conservative treatments, consisting of medication and sialogogues, may benefit from sialendoscopy procedure (14). Sialendoscopy, in which either the submandibular or parotid duct is cannulated with an endoscope, has been described as a diagnostic and therapeutic modality for different pathologies (14,15). To further evaluate the impact of minimally-invasive sialendoscopy on patients' HRQOL, we evaluated the influence of sialendoscopy using the results from two different pre-and post-interventional validated questionnaires, as well as the results of pre-and post-interventional salivary gland scintigrams.…”

Section: Introductionmentioning

confidence: 99%

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Impact of sialendoscopy on improving health related quality of life in patients suffering from radioiodineinduced xerostomia

et al. 2018

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Summary Introduction: Xerostomia following radioiodine therapy (RIT) in patients suffering from differentiated thyroid cancer is a common side effect in 2 % to 67 % of patients treated with radioiodine (I-131). In order to evaluate the impact of sialendoscopy on health related quality of life (HRQOL) in patients suffering from therapy induced sialadenitis and xerostomia, we analyzed findings from two dedicated questionnaires (Xerostomy Questionnaire XQ and Xerostomy Inventory XI) in patients before and three months after sialendoscopy. Procedures: In total, 12 patients suffering from differentiated thyroid carcinoma (10 women and 2 men) were evaluated. All patients had experienced conservative management. Patients were offered a sialendoscopy procedure if no major contradictions were present. Patients who denied the procedure formed the control group. Pre- and (three months) postoperative HRQOL was measured with the Patient Reported Outcome Measures (PROM) Xerostomia Questionnaire (XQ) and the Xerostomia Inventory (XI), as well as by a pre- and post-interventional salivary gland scintigram. Patients were graded according to their sialendoscopical findings. Results: Interventional group presented with significant improvements in HRQOL measurements regarding XQ and XI-scores three months postoperatively. Control group showed no significant changes in the XQ or the XI scores. Number of RIT and cumulative activity of I-131 did not correlate with higher disease grade in regards to sialendoscopical findings nor did it correlate with higher XQand XI scores. Pre- and post-interventional salivary gland scintigram stated that parotid glands are more severely damaged than submandibular glands (SMG), but no significant scintigraphically changes could be detected after sialendoscopy. Conclusion: Sialendoscopy in patients suffering from therapy induced sialadenitis and xerostomia seems to be beneficial when evaluating the impact on HRQOL. Functional parameters measured by salivary gland scintigram did not show significant changes in post-interventional scintigrams.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of sialendoscopy on improving health related quality of life in patients suffering from radioiodineinduced xerostomia

et al. 2018

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“…RI treatment may not only cause discomfort in patients but may also interfere with the treatment of thyroid cancer. In this respect, it is important to manage and control the function of the SGs [2].…”

Section: Introductionmentioning

confidence: 99%

Fucoidan attenuates radioiodine-induced salivary gland dysfunction in mice

Kim

et al. 2019

BMC Oral Health

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Background Radioiodine (RI) treatments can destroy the cellular components of salivary glands (SG) and disrupt their function. This study investigated whether fucoidan could attenuate radioiodine-induced SG dysfunction in a mouse model. Methods Female C57BL/6 mice ( n = 36) were classified into three groups; i) a normal (control) group, ii) an RI-treated group (0.2 mCi/20 g mouse, administered orally), and iii) a fucoidan and RI-treated group. Mice in each group were classified into three subgroups and sacrificed at 2, 4, and 12 weeks after RI treatment. The measurements of salivary flow rates and lag times and histomorphologic examinations were performed, and apoptotic assays were conducted. Changes in salivary 99m Technetium (Tc)-pertechnetate parameters using single-photon emission computed tomography were followed. Results Salivary flow rates and lag times in the fucoidan group were improved compared to the RI-treated group. Histologic examinations of SGs in the fucoidan group showed mucin-rich parenchymal areas and reduced periductal fibrosis as compared to the RI-treated group. Moreover, compared with the RI-treated group, fucoidan-treated groups showed evidence of cytoprotection, with a greater number of salivary epithelial cells and myoepithelial cells being observed. Fewer apoptotic cells were observed in the fucoidan group as compared to the RI group. The extent of 99m Tc pertechnetate excretion in the fucoidan group was similar to that of the control group. Conclusion Our results demonstrate that fucoidan administration before RI treatment could attenuate RI-induced SG damage and provides a possible candidate for preventing SG damage induced by RI.

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“…E para estas mais variadas condições, existem relatos a respeito da amenização dos sintomas de boca seca, efeito reparador e de modulação do processo inflamatório, além de efeito antioxidante que a laserterapia foi capaz de proporcionar.97No entanto, nenhum trabalho na literatura relaciona a TFBM como tratamento para os efeitos colaterais da iodoterapia. As terapias propostas, na literatura, para amenizar os efeitos colaterais da iodeterapia nas glândulas salivares, são substitutos salivares, medicações sialogogas(97,102) e até mesmo procedimentos como a sialoendoscopia(98,99).A laserterapia nas GS parece ter sido eficaz para atenuar o processo de atrofia das GS promovida pelos efeitos da iodoterapia, uma vez que a TFBM agemodulando o processo inflamatório ali presente. A modulação dessa inflamação permitiu a glândula salivar, em parte, recuperar sua função.…”

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Estudo do efeito deletério do iodo-131 nas glândulas salivares de camundongos tratados ou não com laser de baixa potência

Magliano¹

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Agradeço especialmente à Profa Dra Alyne Simões, minha orientadora, pela confiança desde a minha primeira iniciação científica, que começou em 2012, por ter acreditado no meu potencial, me ajudando a enxergar o mundo da pesquisa de maneira recompensadora, e sempre de forma clara e objetiva, a persistir diante de desafios, se tornando um exemplo de profissional para mim. Agradeço também por todas as oportunidades que me foram dadas ao longo desses anos. Foi uma honra e um imenso prazer ser parte da sua equipe. Ao Prof. Dr. Victor Elias Arana-Chavez, meu co-orientador, agradeço imensamente por todos os ensinamentos e pela atenção com o meu trabalho, por dividir seu conhecimento, pelos conselhos, pelo acolhimento e receptividade, no laboratório de Biologia Oral. À Profa Dra Luana de Campos, que além de minha prima, é uma grande amiga, e referência na vida acadêmica e profissional. Foi a primeira pessoa que me mostrou o laboratório, e então tem me acompanhado desde as minhas iniciações científicas até hoje. Sem você esse trabalho nunca teria acontecido. Obrigada por todos os ensinamentos, pela paciência e pela confiança em me permitir dar continuidade à sua ideia.

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Sialendoscopy in the Management of Radioiodine Induced Sialadenitis: A Systematic Review

Cited by 20 publications

References 30 publications

Impact of sialendoscopy on improving health related quality of life in patients suffering from radioiodineinduced xerostomia

Impact of sialendoscopy on improving health related quality of life in patients suffering from radioiodineinduced xerostomia

Fucoidan attenuates radioiodine-induced salivary gland dysfunction in mice

Estudo do efeito deletério do iodo-131 nas glândulas salivares de camundongos tratados ou não com laser de baixa potência

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