Sialendoscopic management of autoimmune sialadenitis: a review of literature

Gallo, Andrea; Martellucci, Salvatore; Fusconi, Massimo; Pagliuca, Giulio; Greco, Antonio; Vincentiis, Marco de

doi:10.14639/0392-100x-1605

Cited by 21 publications

(19 citation statements)

References 58 publications

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“…In IgG4-RS, it is postulated that the inflammatory and fibrotic processes are derived by Th2 and Treg cells secreted cytokines. This is contrary to most autoimmune disorders, where polarized Th1 and/or Th17 subsets are responsible for the inflammatory process [ 4 , 12 , 16 , 125 ].…”

Section: Küttner's Tumor (Igg4-related Sialadenitis) and T Cellsmentioning

confidence: 88%

T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis

Ibrahem

2022

Autoimmune Diseases

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IgG4-related disease is a multiorgan immunological fibroinflammatory disorder characterized by lymphoplasmacytic infiltration and fibrosis in multiple organs accompanied by high serum IgG4 levels. The salivary glands are the most common organs involved in this disease. Recently, chronic sclerosing sialadenitis affecting salivary glands, formerly known as Küttner’s tumor, and Mikulicz’s disease have been classified as a class of IgG4-related diseases. The etiopathobiology of IgG4-related disease is not fully understood. It has recently been hypothesized that the inflammatory and fibrotic process and the increased serum IgG4+ levels in IgG4-related disease are the result of an interaction between B cells and T helper cells, suggesting that T cells may play a key role in the pathogenesis of this disease. The aim of this review is to discuss the proposed roles of different T cell subsets in the pathogenesis of IgG4-related disease focusing on their roles in immunopathogenesis of IgG4-related sialadenitis.

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Section: Küttner's Tumor (Igg4-related Sialadenitis) and T Cellsmentioning

confidence: 88%

T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis

Ibrahem

2022

Autoimmune Diseases

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“…[4][5][6][7] Typically, a sialendoscopy practitioner reports an endoscopic finding in the gland ductal wall to be 'sclerotic', 'with white wall appearance', 'with lack of vascularity' or 'with confined/diffused stenosis' in cases such as chronic sialadenitis, Sjogren Syndrome or in juvenile recurrent parotitis. [8][9][10][11] Nevertheless, these designations remain descriptive and are fairly subjective.…”

Section: Introductionmentioning

confidence: 99%

The sialodynamic test: A preliminary porcine head study

et al. 2022

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Objectives To provide a concept of measuring pressure changes under constant fluid infusion for the diagnosis of sialolithiasis, termed the sialodynamic test, in a porcine head model. Methods Using a porcine head model, a constant infusion of water into the submandibular gland of the two groups over 30 s was performed and the outlet pressure was measured. Metal beads were inserted into the salivary duct for obstruction simulation after the normal submandibular gland sialodynamic measurements were completed. Statistical analyses were performed to evaluate the differences between the measured individuals and the experimental group ( n = 3). Results The results showed no significant difference between individuals in the control group, but intergroup variation was noted in the simulated sialolithiasis group. The volume-dependent linear increase in pressure was exacerbated in the simulated sialolithiasis group compared with the control. Conclusion This study indicated that evaluating the relationship between pressure and volume changes can help to determine whether stones are present in the submandibular gland. The sialodynamic test might serve as a potential diagnostic method for salivary diseases.

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“…Xerostomia and sialadenitis are not rare conditions and can be linked together particularly in case of chronic sialadenitis, 12 especially if they are linked to auto‐immune disorders. 13 Symptoms experienced by patients presenting salivary gland pathologies are assessed by questionnaires that evaluate the patient's complaints and their repercussions on their QOL. As of today, over 100 questionnaires regarding xerostomia and oral pathologies are available in the literature; however, none has been validated to assesses completely both sialadenitis and xerostomia regarding any type of treatment (medical, sialendoscopic, or surgical).…”

Section: Introductionmentioning

confidence: 99%

Novel Multidisciplinary Salivary Gland Society (MSGS) Questionnaire: An International Consensus

et al. 2021

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Objectives: First, establishment and validation of a novel questionnaire documenting the burden of xerostomia and sialadenitis symptoms, including quality of life. Second, to compare two versions regarding the answering scale (proposed developed answers Q3 vs. 0-10 visual analogue scale Q10) of our newly developed questionnaire, in order to evaluate their comprehension by patients and their reproducibility in time.Study Design: The study is a systematic review regarding the evaluation of the existing questionnaire and a cohort study regarding the validation of our new MSGS questionnaire.Materials and Methods: A Multidisciplinary Salivary Gland Society (MSGS) questionnaire consisting of 20 questions and two scoring systems was developed to quantify symptoms of dry mouth and sialadenitis. Validation of the questionnaire was carried out on 199 patients with salivary pathologies (digestive, nasal, or age-related xerostomia, post radiation therapy, post radioiodine therapy, Sjögren's syndrome, IgG4 disease, recurrent juvenile parotitis, stones, and strictures) and a control group of 66 healthy volunteers. The coherence of the questionnaire's items, its reliability to distinguish patients from healthy volunteers, its comparison with unstimulated sialometry, and the time to fill both versions were assessed.Results: The novel MSGS questionnaire showed good internal coherence of the items, indicating its pertinence: the scale reliability coefficients amounted to a Cronbach's alpha of 0.92 for Q10 and 0.90 for Q3. The time to complete Q3 and Q10 amounted, respectively, to 5.23 min (AE2.3 min) and 5.65 min (AE2.64 min) for patients and to 3.94 min (AE3.94 min) and 3.75 min (AE2.11 min) for healthy volunteers. The difference between Q3 and Q10 was not significant.Conclusion: We present a novel self-administered questionnaire quantifying xerostomia and non-tumoral salivary gland pathologies. We recommend the use of the Q10 version, as its scale type is well known in the literature and it translation for international use will be more accurate.

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Sialendoscopic management of autoimmune sialadenitis: a review of literature

Cited by 21 publications

References 58 publications

T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis

T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis

The sialodynamic test: A preliminary porcine head study

Novel Multidisciplinary Salivary Gland Society (MSGS) Questionnaire: An International Consensus

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