Sialadenose durch Valproat-Dauermedikation

Reißer, C.; Maier, H.

doi:10.1055/s-2007-998058

Cited by 4 publications

(3 citation statements)

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“…Iodine compounds, including those used as radiographic contrast media, may cause painful swelling of the parotid and submandibular glands, and some cases of ''iodine mumps'' have been reported. Cases of sialadenitis or sialadenosis have been related to some other drugs, such as bretylium, methyldopa, clonidine, reserpine, isopro- terenol, pilocarpine, nifedipine, phentolamine, guanethidine, scopolamine, tricyclic antidepressants, thiouracil, nitrofurantoin, chlorhexidine mouth rinses and, less probably, antiarrhythmic agents with anticholinergic action and estrogen [4,5]. Although there is experimental evidence that catecholamines such as isoprenaline, even if inhaled, can reproduce the pathological features of sialadenosis, beta-blockers have been therapeutically ineffective [3].…”

Section: Discussionmentioning

confidence: 99%

“…Some specific diseases associated with sialadenosis include sarcoidosis, tuberculosis, syphilis, leukaemia, Hodgkin's disease, Warthin's tumour, malignant lymphoma, lymphoid hyperplasia, gout and Grave's disease [6]. So far, to our knowledge, only one report [5] has linked sialadenosis with the use of valproic acid.…”

Section: Discussionmentioning

confidence: 99%

“…In the only previous report on a valproic acidinduced swelling of the salivary glands [5], a 23-yearold male patient with epilepsy had received valproic acid for 3 years. To improve seizure control, the dose was increased to 2.7 g/day.…”

Section: Discussionmentioning

confidence: 99%

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Valproic acid-associated sialadenosis of the parotid and submandibular glands: diagnostic and therapeutic aspects

Mauz

Mörike²,

Kaiserling

et al. 2005

Acta Oto-Laryngologica

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Sialadenosis has been defined as a non-inflammatory, parenchymatous salivary gland disease causing recurrent, bilateral swelling of the salivary glands. As an adverse drug reaction of valproic acid, sialadenosis is very rare. To our knowledge, it has been reported only once in the world literature to date. We present herein the case of a patient with valproic acid-associated sialadenosis of both the parotid and submandibular glands. This appears to be the first published case of a patient who received surgical treatment. On light and electron microscopy of all the affected salivary glands, granular sialadenosis with predominantly moderate electron-dense secretory cytoplasmatic granules was observed. No relevant degenerative alterations were seen. There was no histological evidence of peripheral neuropathy of the nerve supply, leading to disordered activity of acinar cells by loss of neurosecretory granules. Lateral parotidectomy, performed under neuromonitoring control for safety reasons, is the treatment of choice for chronic recurrent parotitis that does not respond to conservative therapy, particularly if the cosmetic deformity is unacceptable to the patient. If the submandibular glands are involved, partial removal is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%