SIAH1 modulates antiviral immune responses by targeting deubiquitinase USP19
Asela Weerawardhana,
Thilina U. B. Herath,
W. A. Gayan Chathuranga
et al.
Abstract:Tight control of the type I interferon (IFN) signaling pathway is critical for maintaining host innate immune responses, and the ubiquitination and deubiquitination of signaling molecules are essential for signal transduction. Deubiquitinase ubiquitin‐specific protein 19 (USP19) is known to be involved in deubiquitinating Beclin1, TRAF3, and TRIF for downregulation of the type I IFN signaling. Here, we show that SIAH1, a cellular E3 ubiquitin ligase that is involved in multicellular pathway, is a potent positi… Show more
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