SIADH consecutive to ciprofloxacin intake

Adler, Dan; Voide, Cathy; Thorens, Jean-Benoît; Desmeules, Jules Alexandre

doi:10.1016/j.ejim.2004.08.003

Cited by 18 publications

(11 citation statements)

References 5 publications

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“…Owing to its effects on the functioning of the collecting ducts, ciprofloxacin may cause diverse disorders, including hyponatremia, hypokalemia, hyperkalemia, renal tubular acidosis, and nephrogenic diabetes insipidus 16 . The association between ciprofloxacin and hyponatremia has also been investigated in a case report 17 . Because most hyponatremia events are transient and clinically insignificant, hyponatremia might not have been noticed as an ADR.…”

Section: Discussionmentioning

confidence: 99%

Detection of Adverse Drug Reaction Signals Using an Electronic Health Records Database: Comparison of the Laboratory Extreme Abnormality Ratio (CLEAR) Algorithm

Yoon

Park

Choi

et al. 2012

Clin Pharmacol Ther

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Electronic health records (EHRs) are expected to be a good source of data for pharmacovigilance. However, current quantitative methods are not applicable to EHR data. We propose a novel quantitative postmarketing surveillance algorithm, the Comparison of Laboratory Extreme Abnormality Ratio (CLEAR), for detecting adverse drug reaction (ADR) signals from EHR data. The methodology involves calculating the odds ratio of laboratory abnormalities between a specific drug-exposed group and a matched unexposed group. Using a 10-year EHR data set, we applied the algorithm to test 470 randomly selected drug-event pairs. It was found possible to analyze a single drug-event pair in just 109 ± 159 seconds. In total, 120 of the 150 detected signals corresponded with previously reported ADRs (positive predictive value (PPV) = 0.837 ± 0.113, negative predictive value (NPV) = 0.659 ± 0.180). By quickly and efficiently identifying ADR signals from EHR data, the CLEAR algorithm can significantly contribute to the utilization of EHR data for pharmacovigilance.

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Section: Discussionmentioning

confidence: 99%

Detection of Adverse Drug Reaction Signals Using an Electronic Health Records Database: Comparison of the Laboratory Extreme Abnormality Ratio (CLEAR) Algorithm

Yoon

Park

Choi

et al. 2012

Clin Pharmacol Ther

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“…There have been 3 other published cases of SIADH associated with fluoroquinolones, 1 with ciprofloxacin and 2 with moxifloxacin. 9,11,12 In this case, the symptoms started after ciprofloxacin administration in 2012, although the timeline is not as clear in the 2008 incident. SIADH corrected after the drug was discontinued.…”

Section: Discussionmentioning

confidence: 86%

SIADH Associated With Ciprofloxacin

Babar

2013

Ann Pharmacother

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“…Other causes of SIADH include surgery (intense pain and post‐operative nausea stimulate secretion of AVP) and drugs. Among the most commonly drugs are antidepressants (amitriptyline, citalopram and fluoxetine), non‐steroidal anti‐inflammatory drugs, chlorpropamide, tolbutamide, clofibrate, cyclophosphamide, ciprofloxacin, interferon‐alpha, interferon‐gamma, carbamazepine, amiodarone, morphine, amphetamines and ‘ecstasy’ …”

Section: Resultsmentioning

confidence: 99%

Employment of vasopressin receptor antagonists in management of hyponatraemia and volume overload in some clinical conditions

2015

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SUMMARYWhat is known and objective: Hyponatraemia, the most common electrolyte imbalance occurring in hospitalized subjects, is usually classified as hypovolaemic, euvolaemic or hypervolaemic. Hyponatraemia is a predictor of death among subjects with chronic heart failure and cirrhosis. The inappropriate secretion of the antidiuretic hormone (AVP) seems to be of pivotal importance in the decline of serum sodium concentration in these clinical conditions. The objective of this review was to summarize recent progress in management of hyponatraemia in SIADH, cirrhosis and heart failure. Methods: Literature searches were conducted on the topics of hyponatraemia and vasopressin receptor antagonists, using PubMed, pharmaceutical company websites and news reports. The information was evaluated for relevance and quality, critically assessed and summarized. Results and discussion: The initial treatment of severe hyponatraemia is directed towards the prevention or management of neurological manifestations and consists of an intravenous infusion of hypertonic saline. Fluid restriction is indicated in oedematous states. Diuretics alone or in combination with other specific drugs remain the main strategy in the management of volume overload in heart failure. In resistant cases, ultrafiltration can lead to effective removal of isotonic fluid preventing new episodes of decompensation; however, aquapheresis is associated with increased costs and other limits. In several trials, the efficacy of vasopressin receptor antagonists in euvolaemic patients (inappropriate antidiuretic hormone secretion) or in hypervolaemic hyponatraemia (chronic heart failure, cirrhosis) has been evaluated. It was found that vaptans, which promote aquaresis, were superior to a placebo in raising and maintaining serum sodium concentrations in these subjects. What is new and conclusions: Combined with conventional therapy, vasopressin receptor antagonists (AVP-R antagonists) are able to increase the excretion of electrolyte-free water and the sodium concentration. Further studies are needed to assess efficacious outcomes of aquaresis compared with aquapheresis and with conventional therapy. WHAT IS KNOWN AND OBJECTIVEHyponatraemia is variably defined, but a serum sodium concentration below 135 mEq/L is the cut-off most frequently used.1 It is the most common electrolyte imbalance present in hospitalized subjects, with an incidence of 15-22% for values of serum sodium <135 mEq/L and of 1-4% for values <130 mEq/L.2,3 Hyponatraemia is associated with increased morbidity and mortality among subjects with heart, liver or neurologic disease. 4-7The prevalence of hyponatraemia varies widely depending on the clinical setting. The highest frequencies are observed in intensive care units (ICU), in the post-operative setting and in older subjects admitted to geriatric wards. In the latter, this alteration is associated with different compliances and it is due to age-related physiological changes in water and electrolyte balance, as well as in the presence of comorbi...

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SIADH consecutive to ciprofloxacin intake

Cited by 18 publications

References 5 publications

Detection of Adverse Drug Reaction Signals Using an Electronic Health Records Database: Comparison of the Laboratory Extreme Abnormality Ratio (CLEAR) Algorithm

Detection of Adverse Drug Reaction Signals Using an Electronic Health Records Database: Comparison of the Laboratory Extreme Abnormality Ratio (CLEAR) Algorithm

SIADH Associated With Ciprofloxacin

Employment of vasopressin receptor antagonists in management of hyponatraemia and volume overload in some clinical conditions

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