Si Nanorod Array Integrated Microfluidic Device for Enhanced Extracellular Vesicle Isolation
Hanyue Kang,
Cheng Li,
Wenfei Liu
et al.
Abstract:Tumor‐derived extracellular vesicles (EVs) have attracted tremendous interest as one of the early cancer diagnostic markers. The major obstacle preventing EV‐based liquid biopsy is the efficient collection of EVs from the complex body fluid environment. This paper introduces a nanorod‐integrated microfluidic chip capable of immunoaffinity‐isolating EVs. Periodic silicon nanorod arrays in zigzag channels are prepared by nanosphere lithography. Nanorod sidewalls provide larger binding sites for antibodies, and t… Show more
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