Shrinkage and biomechanical evaluation of lightweight synthetics in a rabbit model for primary fascial repair

Ozog, Yves; Konstantinovic, Maja; Werbrouck, E.; Ridder, Dirk De; Mazza, Edoardo; Deprest, Jan

doi:10.1007/s00192-011-1440-1

Cited by 49 publications

(38 citation statements)

References 27 publications

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“…TestXpert II software (Zwick GmbH & Co) was used to record measurements. The stiffness (N/mm) in the comfort (lower forces) and stress (higher forces) zone were calculated [21].…”

Section: Biomechanical Testingmentioning

confidence: 99%

Morphological and Functional Changes in the Vagina following Critical Lifespan Events in the Ewe

Hympánová

Rynkevic

Urbánková

et al. 2019

Gynecol Obstet Invest

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Background/Aims: The ewe is increasingly being used as an animal model for pelvic floor disorders. The aim was to further characterize changes in the vaginal properties during its entire lifespan. Methods: Vaginal tissues were collected at different stages of reproductive life (neonatal, prepubescence, nulliparous, primiparous, multiparous, and menopausal; ≥6 ewes/group). Vaginal size, as well as active and passive biomechanics, was measured. Microscopy included thickness of glycogen, epithelium, lamina propria and muscularis thickness, densities of collagen, elastin, smooth muscle, and nerves. Results: Vaginal dimensions increase during adolescence, peak at reproductive levels, and decrease sharply after ovariectomy. One year after first delivery, the distal vagina gets more compliant, yet this is reversed later in life. The thickness of glycogen staining epithelial layers changed with puberty and menopause. The epithelium was markedly thicker after multiple deliveries. The thickness of lamina propria and muscularis increased in puberty and in nulliparous. Semi-quantitative collagen assessment demonstrated a lower collagen and higher elastin content after first and multiple deliveries. Conclusion: The changes in the ovine vaginal wall during representative moments of her lifespan parallel those observed in women.

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“…TestXpert II software (Zwick GmbH & Co) was used to record measurements. The stiffness (N/mm) in the comfort (lower forces) and stress (higher forces) zone were calculated [21].…”

Section: Biomechanical Testingmentioning

confidence: 99%

Morphological and Functional Changes in the Vagina following Critical Lifespan Events in the Ewe

Hympánová

Rynkevic

Urbánková

et al. 2019

Gynecol Obstet Invest

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“…Previously, explant tensile properties have been characterized at the most basic level, reporting only ultimate tensile stress, strain [13] and Young's modulus [12]. However, more recently it has been recognized that a more detailed analysis of the biomechanical properties is required, with non-linear stressstrain curves divided into the regions identified with soft biological tissue [29], as recent studies are now reporting toe and linear region properties [31]. With changes in mesh biomechanical properties in vivo resulting from new biological growth, it is imperative that biological growth is also characterized.…”

Section: Discussionmentioning

confidence: 98%

Temporal changes in the biomechanical properties of endometrial mesenchymal stem cell seeded scaffolds in a rat model

et al. 2015

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“…Their size also permits the creation of several defects in the same animal as well as the harvesting of larger tissue specimens (Figs. 2, and 3) [24,25]. Rabbits are known to have a different collagen metabolism from man, which may have an impact on wound healing as well as degradation of acellular collagen matrices [26].…”

Section: Purpose and Design Of Animal Models And Experimentsmentioning

confidence: 99%

“…ruler: 1 mm. Reproduced with permission from [25] folding, or migration. The explant dimensions are used to quantify eventual contraction.…”

Section: Outcome Measures For the Evaluation Of Experimental Explantsmentioning

confidence: 99%

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A standardized description of graft-containing meshes and recommended steps before the introduction of medical devices for prolapse surgery

et al. 2012

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Over the past decade, a huge number of new implants and ancillary devices have been introduced to the market. Most of these have become clinically available with little or no clinical data or research. This is a less-than-ideal situation, and this subgroup of the ad hoc IUGA roundtable conference wants to open the discussion to change this, by proposing a pragmatic minimum clearance track for new products being introduced to the market. It consists of an accurate and more standardized product description, data on the biological properties gathered in animal experiments, anatomical cadaveric studies, and upfront clinical studies followed by a compulsory registry on the first 1,000 patients implanted. Ideally, manufacturers should support well-designed prospective (randomized) clinical trials that can support the claimed benefits of the new product.

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Shrinkage and biomechanical evaluation of lightweight synthetics in a rabbit model for primary fascial repair

Abstract: The biomechanical behaviour of the tested lightweights does not mimic that of native controls. Weight reduction does not prevent shrinkage.

Cited by 49 publications

References 27 publications

Morphological and Functional Changes in the Vagina following Critical Lifespan Events in the Ewe

Morphological and Functional Changes in the Vagina following Critical Lifespan Events in the Ewe

Temporal changes in the biomechanical properties of endometrial mesenchymal stem cell seeded scaffolds in a rat model

A standardized description of graft-containing meshes and recommended steps before the introduction of medical devices for prolapse surgery

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