SHREC, an Effector Complex for Heterochromatic Transcriptional Silencing

Sugiyama, Tomoyasu; Cam, Hugh P.; Sugiyama, Rie; Noma, Ken-ichi; Zofall, Martin; Kobayashi, Ryûji; Grewal, Shiv I. S.

doi:10.1016/j.cell.2007.04.014

Cited by 97 publications

(222 citation statements)

References 0 publications

Supporting

Mentioning

210

Contrasting

Unclassified

Order By: Relevance

“…Given that both DNA transposons and LTR retrotransposons are flanked by repetitive DNA structures, and transposases bind to terminal inverted repeats of DNA transposons 2 , it is possible that during evolution a CENP-B precursor acquired the ability to target retrotransposon LTRs, and subsequently was co-opted by the host into its gene repertoire for controlling transposable elements. CENP-B-mediated Tf silencing is, in part, dependent on CENP-Bs recruiting Clr3-containing SHREC and Clr6 HDAC complexes, which are also required for heterochromatic silencing of centromeric repeats 10,21,23 . Thus, CENP-B localization at heterochromatic regions could aid in silencing by means of HDAC recruitment.…”

Section: Discussionmentioning

confidence: 99%

“…Previous analysis revealed three major SHREC peaks at the mating-type (mat) region 23 , two of which appear to correspond to silencer elements near the silent mat cassettes (Fig. 4a).…”

Section: Abp1 Recruits Hdacs To Tf2 and A Heterochromatic Locusmentioning

confidence: 99%

“…The HDACs Clr3 (a component of the SHREC (Snf2/Hdaccontaining repressor complex) silencing complex 23 ) and Clr6 (which exists in multi-subunit complexes 21 ) have been implicated in controlling Tf2 expression in S. pombe 10,21,23 . We investigated potential genetic interactions between HDACs and Abp1 in Tf2 silencing.…”

Section: Abp1 Recruits Hdacs To Tf2 and A Heterochromatic Locusmentioning

confidence: 99%

“…CENP-Bs bind to Tf2 retrotransposons and their remnants, and mediate Tf2 silencing by recruiting the class I histone deacetylase (HDAC) Clr6 (refs 21,22) and the class II HDAC Clr3 (ref. 23). …”

mentioning

confidence: 99%

See 3 more Smart Citations

Host genome surveillance for retrotransposons by transposon-derived proteins

Cam¹,

Noma²,

Ebina

et al. 2007

Nature

Self Cite

159

241

View full text Add to dashboard Cite

Transposable elements and their remnants constitute a substantial fraction of eukaryotic genomes. Host genomes have evolved defence mechanisms, including chromatin modifications and RNA interference, to regulate transposable elements. Here we describe a genome surveillance mechanism for retrotransposons by transposase-derived centromeric protein CENP-B homologues of the fission yeast Schizosaccharomyces pombe. CENP-B homologues of S. pombe localize at and recruit histone deacetylases to silence Tf2 retrotransposons. CENP-Bs also repress solo long terminal repeats (LTRs) and LTR-associated genes. Tf2 elements are clustered into 'Tf' bodies, the organization of which depends on CENP-Bs that display discrete nuclear structures. Furthermore, CENP-Bs prevent an 'extinct' Tf1 retrotransposon from re-entering the host genome by blocking its recombination with extant Tf2, and silence and immobilize a Tf1 integrant that becomes sequestered into Tf bodies. Our results reveal a probable ancient retrotransposon surveillance pathway important for host genome integrity, and highlight potential conflicts between DNA transposons and retrotransposons, major transposable elements believed to have greatly moulded the evolution of genomes.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Previous analysis revealed three major SHREC peaks at the mating-type (mat) region 23 , two of which appear to correspond to silencer elements near the silent mat cassettes (Fig. 4a).…”

Section: Abp1 Recruits Hdacs To Tf2 and A Heterochromatic Locusmentioning

confidence: 99%

Section: Abp1 Recruits Hdacs To Tf2 and A Heterochromatic Locusmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Host genome surveillance for retrotransposons by transposon-derived proteins

Cam¹,

Noma²,

Ebina

et al. 2007

Nature

Self Cite

159

241

View full text Add to dashboard Cite

show abstract

“…Coupling HDACs with ATP-dependent chromatin remodeling activities within a multi-enzyme complex is a strategy also employed by Mi-2/ NURD, NCoR1, NoRC and the yeast SHREC complexes involved in transcriptional repression. [77][78][79][80][81][82] The fact that a functional ATPase domain in SMARCAD1 replication sites including mismatch repair proteins (MSH2/3/6), HDAC1, HDAC2 and G9a. [69][70][71][72] It is important to keep in mind that PCNA and other key replication factors are present at all replication foci.…”

confidence: 99%

Keeping chromatin quiet

Mermoud

Rowbotham²,

Varga‐Weisz³

2011

Cell Cycle

View full text Add to dashboard Cite

Histone deacetylases as transducers and targets of nuclear signaling

Walkinshaw

Tahmasebi

Bertos

et al. 2008

J of Cellular Biochemistry

View full text Add to dashboard Cite

Histone deacetylase (HDAC) activity was first discovered about 40 years ago, but it was not until the molecular identification of the first HDACs in 1996 that this family of enzymes gained prominence. In addition to histones, HDACs reverse lysine acetylation of various non-histone proteins located in the nucleus and the cytoplasm. Here, we examine the nuclear roles of these enzymes, with a specific focus on their active crosstalk with different chromatin regulators.

show abstract

SHREC, an Effector Complex for Heterochromatic Transcriptional Silencing

Cited by 97 publications

References 0 publications

Host genome surveillance for retrotransposons by transposon-derived proteins

Host genome surveillance for retrotransposons by transposon-derived proteins

Keeping chromatin quiet

Histone deacetylases as transducers and targets of nuclear signaling

Contact Info

Product

Resources

About