Should we recommend universal aspirin for all pregnant women?

Mone, Fionnuala; Mulcahy, Cecelia; McParland, Peter; McAuliffe, Fionnuala M.

doi:10.1016/j.ajog.2016.09.086

Cited by 57 publications

(47 citation statements)

References 26 publications

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“…This reduction was even greater in the subgroup in which aspirin was started at 16 weeks’ gestation or earlier at a dose of 100 mg/d or more (RR 0.33, 95% CI 0.19–0.57; P =0.0001). Initiation of aspirin at 16 weeks or more, or a daily dose of less than 100 mg, was not associated with a reduction in preterm or term pre‐eclampsia …”

Section: Preventionmentioning

confidence: 91%

“…Prophylactic aspirin should be given to women identified by screening as being at high risk of developing pre‐eclampsia, rather than to the whole population . The traditional approach has been to define the high‐risk group based on factors in maternal characteristics and medical history .…”

Section: When Aspirin Administration Should Be Recommendedmentioning

confidence: 99%

“…Prophylactic aspirin should be given to women identified by screening as being at high risk of developing pre-eclampsia, rather than to the whole population. 23 The traditional approach has been to define the high-risk group based on factors in maternal characteristics and medical history. 9,24 However, evidence suggests that the most effective way of identifying the high-risk group is through a combination of maternal factors with biophysical and biochemical markers 10,12 as described in the ASPRE trial.…”

Section: When Aspirin Administration Should Be Recommendedmentioning

confidence: 99%

See 2 more Smart Citations

Good clinical practice advice: First trimester screening and prevention of pre‐eclampsia in singleton pregnancy

Renzo¹,

Gratacós²,

Курцер³

et al. 2019

Intl J Gynecology & Obste

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Section: Preventionmentioning

confidence: 91%

Section: When Aspirin Administration Should Be Recommendedmentioning

confidence: 99%

Section: When Aspirin Administration Should Be Recommendedmentioning

confidence: 99%

See 1 more Smart Citation

Good clinical practice advice: First trimester screening and prevention of pre‐eclampsia in singleton pregnancy

Renzo¹,

Gratacós²,

Курцер³

et al. 2019

Intl J Gynecology & Obste

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“…An adverse event such as vaginal bleeding not associated with gestational loss was described (41). Other maternal factors such as allergy or resistance to aspirin, in addition to gastric intolerance, could counterindicate the use of LDA in pregnancy (42). …”

Section: Use Of Aspirin In Prevention Of Pementioning

confidence: 99%

“…However, the controversy regarding the use of LDA persists in low-risk women. Currently, a panel of diagnostic tests exists to determine PE risk that includes uterine artery Doppler pulsatility index, and some placental biomarkers such as pregnancy-associated plasma protein A and placental growth factors (PLGF) (42). However, in developing countries, it is costly to have access to such tests and in that sense, it would be beneficial to recommend the use of LDA in women in whom PE risk is suspected.…”

Section: Use Of Aspirin In Prevention Of Pementioning

confidence: 99%

Aspirin: The Mechanism of Action Revisited in the Context of Pregnancy Complications

Cadavid

2017

Front. Immunol.

101

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Aspirin is one of the most frequently used and cheapest drugs in medicine. It belongs to the non-steroidal anti-inflammatory drugs with a wide range of pharmacological activities, including analgesic, antipyretic, and antiplatelet properties. Currently, it is accepted to prescribe a low dose of aspirin to pregnant women who are at high risk of preeclampsia (PE) because it reduces the onset of this complication. Another pregnancy alteration in which a low dose of aspirin is recommended is the obstetric antiphospholipid syndrome (APS). The most recognized mechanism of action of aspirin is to inhibit the synthesis of prostaglandins but this by itself does not explain the repertoire of anti-inflammatory effects of aspirin. Later, another mechanism was described: the induction of the production of aspirin-triggered lipoxins (ATLs) from arachidonic acid by acetylation of the enzyme cyclooxygenase-2. The availability of a stable analog of ATL has stimulated investigations on the use of this analog and it has been found that, similar to endogenously produced lipoxins, ATL resolves inflammation and acts as antioxidant and immunomodulator. If we consider that in PE and in the obstetric APS, there is an underlying inflammatory process, aspirin might be used based on the induction of ATL. The objective of this review is to revisit the old and new mechanisms of action of aspirin. In particular, it intends to show other potential uses of this drug to prevent certain pregnancy complications in the light of its ability to induce anti-inflammatory and pro-resolving lipid-derived mediators.

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A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre‐eclampsia

Poon

Magee

Verlohren

et al. 2021

Intl J Gynecology & Obste

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Should we recommend universal aspirin for all pregnant women?

Cited by 57 publications

References 26 publications

Good clinical practice advice: First trimester screening and prevention of pre‐eclampsia in singleton pregnancy

Good clinical practice advice: First trimester screening and prevention of pre‐eclampsia in singleton pregnancy

Aspirin: The Mechanism of Action Revisited in the Context of Pregnancy Complications

A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre‐eclampsia

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