Should We Keep Changing the Diagnostic Criteria for Behçet's Disease?

Kronborg, Caroline; Mahar, Patrick; Kelly, Robert

doi:10.1159/000355481

Cited by 12 publications

(12 citation statements)

References 16 publications

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“…Almost every organ and system can eventually be affected by this severe vasculitis. Painful, recurrent oral and genital ulcers are so frequent that their presence is part of the diagnostic criteria [6]. Other skin manifestations are papulopustules, acneiform dermatitis, and erythema nodosum [7].…”

Section: Clinical Picture 21 Non-ocular Diseasementioning

confidence: 99%

Behcet’s Disease

Julian¹,

Bodaghi²

2019

Advances in the Diagnosis and Management of Uveitis

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Defined as a systemic vasculitis developing in a particular genetic background, uveitis is one of the hallmarks to diagnose Behcet's disease and also one of the important clinical criteria to start systemic treatment. Isolated anterior non granulomatous uveitis with hypopyon, even though a classic clinical picture, actually develops in a minority of cases. In most patients, uveitis is posterior, associated to small vessel occlusive retinal vasculitis, carrying a high risk of permanent retinal damage and subsequent severe visual loss. The guarded natural prognosis of the disease has positively changed in the last decennials with the introduction of biologic immunosuppressant agents in the field of uveitis. Vision can be preserved in most cases provided a prompt early diagnosis and adequate therapy. The potential role of oral bacteria as a triggering factor for autoinflammation in predisposed hosts is interesting, opening the door to prevention in this still not well-understood severe uveitis.

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Section: Clinical Picture 21 Non-ocular Diseasementioning

confidence: 99%

Behcet’s Disease

Julian¹,

Bodaghi²

2019

Advances in the Diagnosis and Management of Uveitis

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“…Behçet hastalığı tanısı Uluslararası Behçet Hastalığı Tanı Kriterleri ile belirlendi. 2 Oral aft, genital ülser ve göz bulguları-nın 2'şer puan; deri lezyonları, vasküler bulgular, santral sinir sistemi tutulumu ve pozitif paterji testinin 1'er puan olarak değerlendirildiği skorlamada, alınan 4 ve üzeri puan Behçet hastalığı tanısı koy- durmaktadır. 2 Olgumuz da oral aft, geçirilmiş üveit, papülopüstüler deri lezyonları ve vasküler bulgular ile 6 puan alarak Uluslararası Behçet Hastalığı Tanı Kriterleri'ni karşılamış oldu.…”

Section: Olguunclassified

Rare Coexistence of Psoriasis and Behçet's Disease

Tamer¹,

Rota²

2017

Turkiye Klinikleri J Case Rep

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“…The defining features of Behcet's disease, based on the current diagnostic criteria, are oral and genital ulcers, eye and skin lesions, and abnormalities in the vascular and nervous system, although there is no single definitive test for the disease [3,4]. The cause remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Neurology and Neurobiology doi: 10.31487/j.NNB.2020.01.05 Volume 3(1): [2][3][4][5][6][7][8] However, these are often non-curative and many people with Behcet's experience recurrent episodes of the disorder over time. Behcet's has a variable regional prevalence with the epicentre for the disease occurring in Turkey, where prevalence rates are around 400 per 100,000 [10].…”

Section: Introductionmentioning

confidence: 99%

Psychological and Neurocognitive Impact of Behcet’s Disease

Fisher¹

2020

NNB

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Behcet’s disease is a vasculitis, causing multisystem inflammation and resulting in oral and genital ulcers and eye and skin lesions. A proportion of suffers also have neurological involvement, termed neuro-Behcet’s disease. The purpose of this review was to investigate the psychological and neurocognitive sequelae associated with Behcet’s and neuro-Behcet’s disease and provide directions for future research. Depression and anxiety are the most researched psychological conditions in Behcet’s disease and appear to be the most consistently observed disorders across studies. Depression and anxiety severity is significantly higher relative to controls, and rates are similar across Behcet’s and neuro-Behcet’s cohorts. A systematic review would be helpful to fully determine the magnitude of these psychological disorders in Behcet’s disease and elucidate correlated clinical, regional and demographic factors. Further research is also needed into somatic and psychotic conditions as existing studies have yielded inconsistent results. Attenuations in neurocognitive functioning appear to be on a continuum. Reduced cognitive functioning is observed in Behcet’s disease relative to healthy controls; however, it is observed more frequently in neuro-Behcet’s disease, and in a broader range of neurocognitive domains (visual-spatial abilities, working memory, acquired knowledge, processing speed, long-term memory encoding and retrieval). Methodological limitations in existing studies, thus far, have not allowed for further synthesis of the data, such as through meta-analysis, and the field would benefit from several large-sample, multi-site studies using broad cognitive assessment batteries. Assessments of psychological functioning should be included as part of routine practice in clinics treating patients for Behcet’s disease. The potential for neurocognitive impairment should also be considered, particularly in those with neuro-Behcet’s. Appropriate referral pathways for psychiatric, psychological or neuropsychological intervention and treatment can then be offered, so that the psychological and neurocognitive needs in this patient cohort can be appropriately met.

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Should We Keep Changing the Diagnostic Criteria for Behçet's Disease?

Cited by 12 publications

References 16 publications

Behcet’s Disease

Behcet’s Disease

Rare Coexistence of Psoriasis and Behçet's Disease

Psychological and Neurocognitive Impact of Behcet’s Disease

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