Should we consider telomere length and telomerase activity in male factor infertility?

Balmori, Carlos; Varela, Elisa

doi:10.1097/gco.0000000000000451

Cited by 10 publications

(4 citation statements)

References 70 publications

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“…Telomeres, the guanine-rich nucleoproteins found at the ends of chromosomes, shorten with each cell replication event [60-70 base pair per year] because of incomplete end replication but an enzyme called telomerase can synthesize de novo repeats to these chromosome ends. STL has been positively correlated with embryo morphology in IVF cycles and transplantable embryo rates [166].…”

Section: Summary and Future Directionsmentioning

confidence: 97%

Paternal factors contributing to embryo quality

Colaco

Sakkas

2018

J Assist Reprod Genet

123

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Section: Summary and Future Directionsmentioning

confidence: 97%

Paternal factors contributing to embryo quality

Colaco

Sakkas

2018

J Assist Reprod Genet

123

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“…Another layer of complexity in the aetiology of male infertility is due to the role of telomeres [25][26][27][28][29][30][31], with several studies investigating sperm telomere length (STL) and leukocyte telomere length (LTL) in male infertility [26,29,[31][32][33][34][35]. These studies have been conducted using different study designs, measuring techniques, exposure variables and outcomes, and have a limited sample size, ranging from 20 to 100 in Caucasian males.…”

Section: Introductionmentioning

confidence: 99%

Telomere Length and Male Fertility

Gentiluomo

Luddi

Cingolani

et al. 2021

IJMS

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Over the past decade, telomeres have attracted increasing attention due to the role they play in human fertility. However, conflicting results have been reported on the possible association between sperm telomere length (STL) and leukocyte telomere length (LTL) and the quality of the sperm parameters. The aim of this study was to run a comprehensive study to investigate the role of STL and LTL in male spermatogenesis and infertility. Moreover, the association between the sperm parameters and 11 candidate single nucleotide polymorphisms (SNPs), identified in the literature for their association with telomere length (TL), was investigated. We observed no associations between sperm parameters and STL nor LTL. For the individual SNPs, we observed five statistically significant associations with sperm parameters: considering a p < 0.05. Namely, ACYP2˗rs11125529 and decreased sperm motility (p = 0.03); PXK˗rs6772228 with a lower sperm count (p = 0.02); NAF1˗rs7675998 with increased probability of having abnormal acrosomes (p = 0.03) and abnormal flagellum (p = 0.04); ZNF208˗rs8105767 and reduction of sperms with normal heads (p = 0.009). This study suggests a moderate involvement of telomere length in male fertility; however, in our analyses four SNPs were weakly associated with sperm variables, suggesting the SNPs to be pleiotropic and involved in other regulatory mechanisms independent of telomere homeostasis, but involved in the spermatogenic process.

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“…The telomere size was evaluated in the blood leukocytes of azoospermic males [102]. In a study by Ferlin [103] on male infertility, LTL and SLT were found to be substantially associated [104][105][106].…”

Section: The Role Of Tl and Prognosis Of Noamentioning

confidence: 99%

The Hidden Factor of Azoospermia: Telomere Effect

Sümer Sertyel

2024

Genetics

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Nonobstructive azoospermia (NOA), which results from defective spermatogenesis, is the absence of spermatozoa in the semen. NOA is a complex and multigenetic disorder that is caused by genetic and environmental factors. For the process of spermiogenesis to be fully completed, the functions of telomeres and their length in reproduction are crucial. In recent years, many studies have been published on how leukocyte telomere length might play an important role in the pathophysiology of azoospermia. They show that shorter leucocyte telomere length (LTL) is strongly associated with NOA and defective spermatogenesis. Telomeres preserve human gametogenesis and fertility while preventing chromosomal ends from eroding. The length of the telomere significantly determines how it functions. The proteins are unable to attach to telomeric regions and cannot perform capping at chromosomal ends once telomere shortening rises above a crucial threshold. It is important to include LTL evaluations as a precursor test in the treatment planning that can be created for azoospermic patients.

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Should we consider telomere length and telomerase activity in male factor infertility?

Abstract: Telomere length and telomerase levels can be used as biomarkers of male fertility. Higher STL can have beneficial effects on fertility, thus the use of spermatozoids with longer telomere length in an assisted reproduction technique (ART) could be one way of solving some infertility cases.

Cited by 10 publications

References 70 publications

Paternal factors contributing to embryo quality

Paternal factors contributing to embryo quality

Telomere Length and Male Fertility

The Hidden Factor of Azoospermia: Telomere Effect

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