“…ti is generally considered to be an inert metal due to its titanium oxide (tio 2 ) layer (3,21,29); but, like other metals that are in contact with biological systems, ti may corrode and release ion and other particles (8,33). Such particles may be accumulated on the adjacent tissues (17,24,25) or may be carried to distant organs with the blood (15,26,27). the main parts of the dental implants, which are embedded in the jaw bone, release ions directly to the body.…”