Should There Be Statistical Guidelines for Medical Research Papers?

O’Fallon, Judith R.; Dubey, Satya D.; Salsburg, David S.; Edmonson, John H.; Soffer, Alfred; Colton, Theodore

doi:10.2307/2530390

Cited by 48 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Weibull model for survival data, obtained using the stepwise method, was used to analyse the deaths; the statistical hazard ratio is given for variables included in this model. Differences between proportions are presented as the 95% confidence interval (CI) (7). A P value , 0.05 was considered statistically significant.…”

Section: Statisticsmentioning

confidence: 99%

Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA)

Mestrón

Webb

Astorga

et al. 2004

European Journal of Endocrinology

348

232

View full text Add to dashboard Cite

Objective: To undertake a multicentre epidemiological study reflecting acromegaly in Spain. Design: Voluntary reporting of data on patients with acromegaly to an online database, by the managing physician. Methods: Data on demographics, diagnosis, estimated date of initial symptoms and diagnosis, pituitary imaging, visual fields, GH and IGF-I concentrations (requested locally), medical, radiotherapy and neurosurgical treatments, morbidity and mortality were collected. Results: Data were included for 1219 patients (60.8% women) with a mean age at diagnosis of 45 years (S.D. 14 years). Reporting was maximal in 1997 (2.1 cases per million inhabitants (c.p.m.) per year); prevalence was globally 36 c.p.m., but varied between 15.7 and 75.8 c.p.m. in different regions. Of 1196 pituitary tumours, most were macroadenomas (73%); 81% of these patients underwent surgery, 45% received radiotherapy and 65% were given medical treatment (somatostatin analogues in 68.3% and dopamine agonists in 31.4%). Cures (GH values (basal or after an oral glucose tolerance test) , 2 ng/ml, normal IGF-I, or both) were observed in 40.3% after surgery and 28.2% after radiotherapy. Hypertension (39.1%), diabetes mellitus (37.6%), hypopituitarism (25.7%), goitre (22.4%), carpal tunnel syndrome (18.7%) and sleep apnoea (13.2%) were reported as most frequent morbidities; 6.8% of the patients had cancer (breast in 3.1% of the women and colon in 1.2% of the cohort). Fifty-six patients died at a mean age of 60 years (S.D. 14 years), most commonly of a cardiovascular cause (39.4%); mortality was greater in patients given radiotherapy (hazard ratio 2.29; 95% confidence interval 1.03 to 5.08; P ¼ 0.026), and in those in whom GH and IGF-I concentrations were never normal (P , 0.001). Conclusions: This acromegaly registry offers a realistic overview of the epidemiological characteristics, treatment outcome and morbidity of acromegaly in Spain. As active disease and treatment with radiotherapy are associated with an increase in mortality, efforts to control the disease early are desirable.

show abstract

Section: Statisticsmentioning

confidence: 99%

Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA)

Mestrón

Webb

Astorga

et al. 2004

European Journal of Endocrinology

348

232

View full text Add to dashboard Cite

show abstract

“…Secondly, the valid approaches deal with "xed e!ects of a time-varying endpoint, that could be di$cult to interpret, notably by practising physicians. Finally, as a simple tool in training practitioners, reviewing procedures of medical journals should be modi"ed in both rejecting biased approaches and favouring the di!usion of suitable methods, as both suggested by medical [27] and biostatistical [28] professionals.…”

Section: Discussionmentioning

confidence: 99%

Measures of treatment effectiveness on tumour response and survival: a multi-state model approach

2000

View full text Add to dashboard Cite

“…This method is basically a function in MATLAB (MathWorks, Natick, Massachusetts, USA), which is a powerful software package for drawing and analyzing data, programming, and performing engineering and research calculations [31][32][33][34]. Thus, we analyzed data from MATLAB with Statistical Package for the Social Sciences (SPSS; IBM, Armonk, New York, USA) software for discussing statistical aspects and give comparable results of our study.…”

Section: Introductionmentioning

confidence: 99%

Morphological Investigation and Fractal Properties of Realgar Nanoparticles

Lashgari

Ghamami

Bahrami

et al. 2015

Journal of Nanomaterials

View full text Add to dashboard Cite

Some arsenic compounds can show extraordinary polymorphism. Realgar (As 4 S 4 ) is among several minerals with various crystal forms and is one of the most important sources of arsenic for pharmaceutical use. Currently, realgar is used as an arsenic source in many industries, such as weaponry, publishing, textiles, cosmetics, and health products. In this paper, we used and reported new methods for the purification, nanonization, and structural morphological investigations of As 4 S 4 by using planetary ball mills process for nanonization of the compound. The product was characterized using X-ray powder diffraction analysis, Fourier transform infrared spectrometry spectra, and field emission scanning electron microscope (FESEM) imaging. We investigated the morphological properties of FESEM-imaged realgar nanoparticles by an image-processing technique that calculates fractal dimensions using values on a computer with MATLAB software. We applied the Statistical Package for the Social Sciences software for statistics data extracted from the FESEM image and obtained the statistics results of the fractal dimension and histogram plot for the FESEM image.

show abstract

Should There Be Statistical Guidelines for Medical Research Papers?

Cited by 48 publications

References 0 publications

Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA)

Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA)

Measures of treatment effectiveness on tumour response and survival: a multi-state model approach

Morphological Investigation and Fractal Properties of Realgar Nanoparticles

Contact Info

Product

Resources

About