Should the Method of Coutard be Applied in All Cases of Cancer Treated by Roentgen Rays?

Chamberlain, W. Edward; Young, Barton R.

doi:10.1148/29.2.186

Cited by 7 publications

(4 citation statements)

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“…However, systematic work by Henri Coutard in Paris in the 1920s showed that healthy tissue could survive around a treated volume if the radiation was delivered in a number of small doses, which is today termed fractionation [11,12]; the radiobiological justification for fractionation is now often described using the five R's: Repair, Repopulation, Redistribution, Re-oxygenation, and Radioresistance [13][14][15]. Consideration of clinical benefit with respect to x-ray source usage by Ralston Paterson and others led to the rational justification of particular fractionation regimens such as the Manchester hypofractionation system, which remain today as the primary models of treatment [16,17].…”

Section: X-ray Radiotherapymentioning

confidence: 99%

Hadron accelerators for radiotherapy

Owen

Mackay

Peach

et al. 2014

Contemporary Physics

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Over the last twenty years the treatment of cancer with protons and light nuclei such as carbon ions has moved from being the preserve of research laboratories into widespread clinical use. A number of choices now exist for the creation and delivery of these particles, key amongst these being the adoption of pencil beam scanning using a rotating gantry; attention is now being given to what technologies will enable cheaper and more effective treatment in the future. In this article the physics and engineering used in these hadron therapy facilities is presented, and the research areas likely to lead to substantive improvements. The wider use of superconducting magnets is an emerging trend, whilst further ahead novel high-gradient acceleration techniques may enable much smaller treatment systems. Imaging techniques to improve the accuracy of treatment plans must also be developed hand-in-hand with future sources of particles, a notable example of which is proton computed tomography.

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Section: X-ray Radiotherapymentioning

confidence: 99%

Hadron accelerators for radiotherapy

Owen

Mackay

Peach

et al. 2014

Contemporary Physics

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“…(1) can be solved for the u i using Eqs. (2) and (3). Using the Lagrange multiplier formalism it can be shown that in order to maximize the effect E T for any given number of fractions N all the u i 's must be equal (=u * ), hence equal doses per fraction u * D to the tumor are optimal.…”

Section: A Derivation Of the Bifurcation Numbermentioning

confidence: 99%

“…Hence, it was recognized that under certain circumstances, the usual biological advantage of a normal tissue being more sensitive to fractionation could be reversed. 2 Image-guided radiation therapy (IGRT) has revived hypofractionation for small targets. Advances in LINAC technology and image guidance procedures, i.e., on-board kilovolt (kV) imaging, patient setup and immobilization, and fast online corrections, have enabled precision high dose per fraction radiotherapy treatments.…”

Section: Introductionmentioning

confidence: 99%

A novel dose-volume metric for optimizing therapeutic ratio through fractionation: Retrospective analysis of lung cancer treatments

et al. 2013

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“…fracciones, permitiendo aplicar mayor dosis total de radiación al tumor con unos efectos secundarios menores [37]. La forma más común de realizar el tratamiento es administrar una dosis diaria, cinco días a la semana (de lunes a viernes), durante 4 a 6 semanas.…”

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Mejoras en el procesamiento de imágenes de TC para el tratamiento con radioterapia adaptativa del cáncer de próstata

Vila¹

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IV.3.2 Métrica de error IV.3.3 Reconstrucción volumétrica IV.3.4 Tiempo de ejecución IV.3.5 Influencia del MER sobre la delineación del GTV V. CONCLUSIONES Y TRABAJOS FUTUROS V.1 Verificación de las hipótesis de investigación V.1.1 Hipótesis general V.1.2 En lo relativo a imágenes con contraste variable V.1.3 En lo relativo a la presencia de contenidos rectales V.1.4 En lo relativo a la evaluación de los contornos del GTV V.2 Contribuciones principales V.3 Publicaciones científicas V.3.1 Revistas indexadas V.3.2 Capítulos de libros V.3.3 Congresos Internacionales V.3.4 Congresos nacionales V.3.5 Trabajos presentados en seminarios internacionales V.4 Trabajos futuros V.4.1 En lo relativo a los algoritmos de registro deformable V.4.2 En lo relativo al MER V.4.3 En lo relativo al tratamiento del contraste radiológico V.4.4 En lo relativo a evaluación cuantitativa V.4.5 En lo relativo al método Origami V.4.6 En lo relativo a la implementación clínica REFERENCIAS BIBLIOGRÁFICAS

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Should the Method of Coutard be Applied in All Cases of Cancer Treated by Roentgen Rays?

Cited by 7 publications

References 0 publications

Hadron accelerators for radiotherapy

Hadron accelerators for radiotherapy

A novel dose-volume metric for optimizing therapeutic ratio through fractionation: Retrospective analysis of lung cancer treatments

Mejoras en el procesamiento de imágenes de TC para el tratamiento con radioterapia adaptativa del cáncer de próstata

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