Should primary tuberculosis in childrencontinue to be neglected

Hsu, Katharine H. K.

doi:10.1016/s0022-3476(56)80081-4

Cited by 17 publications

(7 citation statements)

References 21 publications

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“…97,156–163 In general, intermittent regimens were associated with less hepatotoxicity, but were also frequently used for less serious forms of tuberculosis.…”

Section: Hepatotoxicity Of Antituberculosis Agents In Children Treatementioning

confidence: 99%

“…Two papers report early studies in which INH monotherapy was used to manage tuberculosis disease in 218 children; 163,164 in only one were liver functions studied and four of 50 (8%) children had increased LFT values. 164 One child (0.46%) developed jaundice.…”

Section: Hepatotoxicity Of Antituberculosis Agents In Children Treatementioning

confidence: 99%

“…12,102,156,163,165–173 The additional drugs commonly used were SM, PAS and EMB and in one study PZA. 172 Jaundice occurred in 12 children (0.39%); serum transaminase values were routinely determined in 443 children and increased in 49 (11.1%).…”

Section: Hepatotoxicity Of Antituberculosis Agents In Children Treatementioning

confidence: 99%

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Antituberculosis Drug-Induced Hepatotoxicity in Children

Donald

2011

Pediatric Reports

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Recent increases in the dosages of the essential antituberculosis agents isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA) for use in children recommended by World Health Organization have raised concerns regarding the risk of hepatotoxicity. Published data relating to the incidence and pathogenesis of antituberculosis drug-induced hepatotoxicity (ADIH), particularly in children, is reviewed. Amongst 12,708 children receiving chemoprophylaxis, mainly with INH, but also other combinations of INH, RMP and PZA only 1 case (0.06%) of jaundice was recorded and abnormal liver functions documented in 110 (8%) of the 1225 children studied. Excluding tuberculous meningitis (TBM) 8984 were children treated for tuberculosis disease and jaundice documented in 75 (0.83%) and abnormal liver function tests in 380 (9.9%) of the 3855 children evaluated. Amongst 717 children treated for TBM, however, jaundice occurred in 72 (10.8%) and abnormal LFT were recorded in 174 (52.9%) of those studied. Case reports document the occurrence of ADIH in at least 63 children. Signs and symptoms of ADIH were frequently ignored in the recorded cases. ADIH can occur in children at any age or at any dosage of INH, RMP or PZA, but the incidence of.ADIH is is considerably lower in children than in adults. Children with disseminated forms of disease are at greater risk of ADIH. The use of the higher dosages of INH, RMP and PZA recently recommended by WHO is unlikely to result in a greater risk of ADIH in children.

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“…97,156–163 In general, intermittent regimens were associated with less hepatotoxicity, but were also frequently used for less serious forms of tuberculosis.…”

Section: Hepatotoxicity Of Antituberculosis Agents In Children Treatementioning

confidence: 99%

Section: Hepatotoxicity Of Antituberculosis Agents In Children Treatementioning

confidence: 99%

See 1 more Smart Citation

Antituberculosis Drug-Induced Hepatotoxicity in Children

Donald

2011

Pediatric Reports

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“…Among the positive reactors, 95.5 per cent had an indurated area greater than 10 mm, only 4.5 per cent had a mild reaction of [6][7][8][9][10] The attendance of adult contacts was much less than the children, especially among the working men who found it difficult to take time off for the required examination.…”

Section: Results Of Contact Investigationmentioning

confidence: 99%

Contact Investigation: A Practical Approach to Tuberculosis Eradication

Hsu

1963

Am J Public Health Nations Health

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“…8 In 1956, Katherine Hsu asked the same questions about why primary TB infection in children continues to be neglected. 9 She then published impressive evidence of effectiveness of implementation of IPT in children in the USA over subsequent decades. 10,11 Surely the time has come to stop missing opportunities for preventive therapy in children in high-burden settings.…”

mentioning

confidence: 99%

Missed opportunities for prevention of tuberculosis in children

Graham

2011

Annals of Tropical Paediatrics

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Should primary tuberculosis in childrencontinue to be neglected

Cited by 17 publications

References 21 publications

Antituberculosis Drug-Induced Hepatotoxicity in Children

Antituberculosis Drug-Induced Hepatotoxicity in Children

Contact Investigation: A Practical Approach to Tuberculosis Eradication

Missed opportunities for prevention of tuberculosis in children

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