Should pediatric kidneys be used in cadaveric kidney transplantation?

Al-Shaibani, Khalid; Raza, S; Almeshari, Khalid; Alfurayh, Osman; Alahmadi, Ibrahim; Al‐Sabban, Essam; Sanjad, Sami A.

doi:10.1016/s0041-1345(98)00962-2

Cited by 2 publications

(5 citation statements)

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“…Recently, there have been multiple reports on the use of pediatric kidney donors. While some suggest a lower graft survival (10,11,24) others have reported comparable graft survival and function to those from adult donors (12)(13)(14)25). In contrast to studies suggesting that early graft failure and smaller nephron mass result in poorer graft survival, our data suggest that the use of pediatric donors in SPK transplantation results in better kidney and pancreas graft survival in adult recipients of pediatric donor organs when compared to adult recipients of adult donor organs.…”

Section: Discussioncontrasting

confidence: 69%

“…In the past, pediatric organs have been considered marginal for use as a result of smaller nephron mass, increased surgical complications, primary non-function and rejection (8,10,12,(14)(15)(16). Recently, there have been multiple reports on the use of pediatric kidney donors.…”

Section: Discussionmentioning

confidence: 99%

“…However, recent studies have reported good long-term results utilizing pediatric kidneys in adult recipients. Improvement in surgical technique and optimization of immunosuppression has led several retrospective analyses to report minimal differences in serum creatinine, patient survival and graft survival between recipients of adult and pediatric donor organs (12)(13)(14)(15). In general, the use of pediatric donors for renal transplantation has been shown to result in good graft function.…”

Section: Introductionmentioning

confidence: 99%

“…In general, the use of pediatric donors for renal transplantation has been shown to result in good graft function. However, there is no established consensus of the suitable age limit of pediatric donor organs and the true incidence of vascular complications (8,10,12,(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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Superior Long-Term Results of Simultaneous Pancreas–Kidney Transplantation from Pediatric Donors

Fernández

Turgeon

Odorico

et al. 2004

American Journal of Transplantation

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The shortage of cadaveric donors for simultaneous pancreas-kidney transplantation has prompted the use of cadaveric organs from pediatric donors. The long-term outcome and its impact on overall longterm survival are unknown. A total of 680 recipients receiving cadaver Simultaneous pancreas-kidney (SPK) transplantation from pediatric and adult donors between July 1986 and September 2001 were analyzed and compared. Ten-year kidney and pancreas graft survival for SPK transplantation from donors aged <18 years (n = 142) were 80% and 72%, respectively, compared to 61% pancreas and kidney graft survival from donors ≥18 years of age (n = 538; p = 0.03 and 0.05, respectively). Five years post-transplant, blood glucose, HbA 1 c and creatinine clearance were significantly better in recipients from pediatric donors (85.3 ± 13 mg/dL, 5.5 ± 3.5% and 65.6 ± 16 mL/min, respectively), compared to recipients from adult donors (95.1 ± 29 mg/dL, 5.9 ± 3.5% and 58.3 ± 17 mL/min; p = 0.001, 0.01 and 0.002, respectively). Causes of graft failure for kidney and pancreas transplants were similar between the two groups. No statistically significant difference was observed in patient survival between recipients from pediatric donors compared to adult donors (85% vs. 76%, p = 0.29). When recipients of SPK from pediatric donors were stratified according to age (3-11 years and 12-17 years) and compared, no difference in kidney or pancreas graft survival was observed (kidney 76.4% vs. 81.3%, p = 0.15; pancreas 75% vs. 76%, p = 0.10, respectively). Pediatric donors represent a valuable source of organs, providing excellent short-and long-term outcomes. Wide utilization of pediatric organs will substantially increase the donor pool.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Superior Long-Term Results of Simultaneous Pancreas–Kidney Transplantation from Pediatric Donors

Fernández

Turgeon

Odorico

et al. 2004

American Journal of Transplantation

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“…Cuatro de los seis receptores cursaron con función renal adecuada a 4 años promedio de seguimiento, concordante con la sobrevida que reportan otros autores ( 6,9,15 ). La causa de la pérdida de uno de los casos de injerto en bloque fue secundario a trombosis venosa post rechazo vascular severo y la pérdida del otro caso fue por inobservancia a la medicación inmunosupresora a dos años de exitosa evolución.…”

Section: Discussionunclassified

Trasplante renal en bloque de donantes pediátricos

et al. 2013

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Should pediatric kidneys be used in cadaveric kidney transplantation?

Cited by 2 publications

References 4 publications

Superior Long-Term Results of Simultaneous Pancreas–Kidney Transplantation from Pediatric Donors

Superior Long-Term Results of Simultaneous Pancreas–Kidney Transplantation from Pediatric Donors

Trasplante renal en bloque de donantes pediátricos

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