Should Omentectomy Be a Part of Surgical Staging in Patients with Endometrioid Adenocarcinoma of the Uterine Corpus?

Ülker, Volkan; Tunca, Aysun Fendal; Numanoğlu, Ceyhun; Akbayır, Özgür; Akyol, Alpaslan; Erim, Adnan; Ongut, Cuneyt

doi:10.1159/000357270

Cited by 10 publications

(4 citation statements)

References 20 publications

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“…Only one patient with omentectomy with tumour involvement showed nuclear positivity for -catenin, but there was no statistical significance associated. Nonetheless, even low-grade ECs with -catenin mutation may behave aggressively and disseminate into the peritoneum 9 . A tumour size > 2cm was noticed in 8/11 cases of ECs with -catenin positivity.…”

Section: Resultsmentioning

confidence: 99%

Βeta-catenin – an important immunohistochemical tool in stratifying endometrial carcinomas?

Evsei¹,

Birceanu-Corobea²,

Ghiţă³

et al. 2021

Arch Balk Med Union

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La bêta-caténine -un outil immunohistochimique important dans la stratification des carcinomes endométriaux?Introduction. Des recherches récentes ont montré que l'expression de la -caténine nucléaire immunohistochimique est un substitut valide pour la mutation de l'exon 3 CTNBB1 dans les carcinomes de l'endomètre (CE). Cette mutation est un facteur pronostique indépendant et identifie un sous-groupe de carcinomes de l'endomètre à bas degré qui ont une tendance à la récidive et à un pronostic défavorable. L'objectif de l'étude était d'évaluer l'expression de la -caténine nucléaire dans différents sous-groupes moléculaires de CE. Matériel et méthodes. Nous avons testé l'expression immunohistochimique de la -caténine nucléaire dans 50 cas de carcinomes de l'endomètre diagnostiqués dans deux unités cliniques. Une analyse statistique a ABSTRACTIntroduction. Recent research has demonstrated that the immunohistochemical nuclear -catenin expression is a valid surrogate for CTNNB1 exon 3 mutation in endometrial carcinomas (ECs). This mutation is an independent prognostic factor which identifies a subgroup of low-grade endometrial carcinomas that have a tendency for recurrence and worse prognosis. The objective of the study was to evaluate nuclear -catenin expression in different molecular subgroups of E Cs. Material and methods. We tested immunohistochemical nuclear -catenin expression in 50 cases of endometrial carcinomas diagnosed in two clinical institutions. Statistical analysis was performed between -catenin expression and various clinical, demographic, pathological and immunohistochemical parameters (age, myometrial invasion, FIGO grade, histopathological subtype, hormone receptors -ER, PR etc). Additionally, we analysed what molecular subgroup

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Section: Resultsmentioning

confidence: 99%

Βeta-catenin – an important immunohistochemical tool in stratifying endometrial carcinomas?

Evsei¹,

Birceanu-Corobea²,

Ghiţă³

et al. 2021

Arch Balk Med Union

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“…Specifically, omentectomy has a significant role in staging of endometrium- and ovarian-origin tumors[ 42 - 44 ]. In gynecological tumors, omental involvement is observed in 9%-37.5% of cases[ 45 - 47 ]. Involvement of the omentum indicates a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Is omentectomy necessary in the treatment of benign or malignant abdominal pathologies? A systematic review

Atay¹,

Dılek²

2021

WJGS

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BACKGROUND The omentum is an organ that is easily sacrificed during abdominal surgery. The scope of omentectomy and whether a routine omentectomy should be performed are still unknown. AIM To review the literature in order to determine the physiological functions of the omentum and the roles it plays in pathological events in order to reveal the necessity for removal and preservation of the omentum. METHODS A clinical review of the English language literature based on the MEDLINE (PubMed) database was conducted using the keywords: “abdomen”, “gastrointestinal”, “tumor”, “inflammation”, “omental flap”, “metastasis”, “omentum”, and “omentectomy”. In addition, reports were also identified by systematically reviewing all references in retrieved papers. RESULTS The omentum functions as a natural barrier in areas where pathological processes occur in the abdominal cavity. The omentum limits and controls inflammatory and infectious pathologies that occur in the abdomen. It also aids in treatment due to its cellular functions including lymphatic drainage and phagocytosis. It shows similar behavior in tumors, but it cannot cope with increasing tumor burden. The stage of the disease changes due to the tumor mass it tries to control. Therefore, it is considered an indicator of poor prognosis. Due to this feature, the omentum is one of the first organs to be sacrificed during surgical procedures. However, there are many unknowns regarding the role and efficacy of the omentum in cancer. CONCLUSION The omentum is a unique organ that limits and controls inflammatory processes, foreign masses, and lesions that develop in the abdominal cavity. Omental flaps can be used in all anatomical areas, including the thorax, abdomen, pelvis, and extremities. The omentum is an organ that deserves the title of the abdominal policeman. It is generally accepted that the omentum should be removed in cases where there is tumor invasion. However, the positive or negative contribution of omental resection in the treatment of abdominal pathologies should be questioned.

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“…Despite high morbidity, multiple therapeutic strategies of malignant uterine tumors have been developed gradually [22,23]. Nevertheless, only patients responding to effective treatment gain survival benefits.…”

Section: Discussionmentioning

confidence: 99%

Standardized Uptake Value on <sup>18</sup>F-FDG PET/CT as a Prognostic Factor for Survival of Women with Malignant Uterine Tumors: A Meta-Analysis

Pan

Yao²,

Ma³

2015

Gynecol Obstet Invest

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Background: Malignant uterine tumors are crucial in the evaluation of prognosis and the determination of therapeutic strategy. Aim: This meta-analysis of the available literature aimed to investigate the prognostic value of standardized uptake value (SUV) on fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography (¹⁸F-FDG PET/CT) in uterine malignancies before treatment. Methods: The PubMed, MEDLINE and EMBASE databases (1990 to February 2014) were searched to identify studies evaluating SUV on ¹⁸F-FDG PET/CT as a prognostic tool for predicting long-term survival in patients with carcinomas of the uterus. The χ² test and the I² index were used to estimate heterogeneity among the trials selected in the meta-analysis. The combined hazard ratio was calculated by using a fixed- or random-effects model according to heterogeneity. Results: Thirteen studies with a total of 1,196 patients were eligible for analysis. High pretreatment SUV_max was significantly associated with poorer event-free survival and overall survival, and the summarized hazard ratio was 3.33 (95% confidence interval 2.34-4.74) and 1.31 (95% confidence interval 1.03-1.67), respectively. Conclusion: The present evidence indicates that SUV on ¹⁸F-FDG PET/CT seems to be a valuable prognostic indicator for survival of patients with malignant uterine tumors. Given that ¹⁸F-FDG PET/CT can provide both morphologic and functional information, we suggest utilizing PET/CT and its quantitative marker in uterine malignancies before treatment.

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Should Omentectomy Be a Part of Surgical Staging in Patients with Endometrioid Adenocarcinoma of the Uterine Corpus?

Cited by 10 publications

References 20 publications

Βeta-catenin – an important immunohistochemical tool in stratifying endometrial carcinomas?

Βeta-catenin – an important immunohistochemical tool in stratifying endometrial carcinomas?

Is omentectomy necessary in the treatment of benign or malignant abdominal pathologies? A systematic review

Standardized Uptake Value on <sup>18</sup>F-FDG PET/CT as a Prognostic Factor for Survival of Women with Malignant Uterine Tumors: A Meta-Analysis

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