Should Melatonin Be Used as an Alternative Sedative and Anxiolytic Agent in Mandibular Third Molar Surgery?

Torun, Aysun Çağlar; Yuceer, Ezgi

doi:10.1016/j.joms.2019.02.045

Cited by 4 publications

(8 citation statements)

References 19 publications

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“…Seet et al (2015) was considered unclear for incomplete outcome data and high risk for selective reporting. Other bias was considered the administration of other substances (Chitsazi et al, 2017; Cobo‐Vázquez et al, 2014; Seet et al, 2015; Isik et al, 2008; Ansari et al, 2018; Faghihian et al, 2018; Torun & Yüceer, 2019; Elsabagh et al, 2020; Lozano et al, 2021; El‐Gammal et al, 2016; Hazzaa et al, 2019; Lee & Curtin, 2020).…”

Section: Resultsmentioning

confidence: 99%

“…Four studies analyzed the melatonin as a premedication to reduce the anxiety before the anesthesia or sedation for dental procedures (Ansari et al, 2018; Faghihian et al, 2018; Isik et al, 2008; Torun & Yüceer, 2019). In three of them, using the dosages of 0.4 mg/kg (Ansari et al, 2018) and 0.5 mg/kg (Faghihian et al, 2018; Torun & Yüceer, 2019) positive effects were observed. However, in the total dosage of 3 mg, no difference was observed (Isik et al, 2008).…”

Section: Results Of the Studies According To The Specific Dental Cond...mentioning

confidence: 99%

“…As for the melatonin group, they were calmer and did not present any difficulties trans surgery. Another aspect is that the gender was not something that showed differences among the studies (Faghihian et al, 2018;Torun & Yüceer, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…In this review, it was reported four different studies that analyzed the preoperative anxiety in patients that would be submitted to dental surgery but not all of them have specified the type of procedure that was conducted. However, the research of Torun and Yüceer (2019) showed that melatonin when administered systemically (0.4 mg/Kg) as a premedication in patients who were submitted to third molar extraction presented an anxiolytic effect and did not show any side effect such as psychomotor dysfunction, promoted by medications as midazolam. This can be explained because of the action of the melatonin in MT1 and MT2 receptors in cells, which causes g‐aminobutyric acid (GABA) modulation in the brain, leading to antialiasing and sedation (Marseglia et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…For the orally administration, depending on which condition and tissue, the dosage of 2mg/day showed to be enough (Chitsazi et al, 2017). However, for emotional conditions, such as preoperative anxiety, higher doses are required (Torun & Yüceer, 2019), being suggested the conduction of new studies that administer higher dosages on patients to analyze criteria such as post or preoperative pain and pre surgery anxiety (Borazan et al, 2010). Thus, depending on the indication, the efficiency of systemic administration may be higher than topical, or the other way around.…”

Section: Discussionmentioning

confidence: 99%

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Melatonin as an adjunctive treatment on dental procedures: A systematic review

et al. 2021

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The systematic review tried to answer the following question: Does the melatonin administered systemically or topically ameliorate patients involved with oral health conditions or dental procedures? The systematic review has been registered in the PROSPERO (2021CRD42021095959). Eligibility criteria included only randomized controlled clinical trials (RCTs) with at least 10 participants that compared patients that received melatonin as a treatment before and/or after their oral intervention topically or systemically, with control patients. A search was performed in PubMed/MEDLINE, Web of Science, Cochrane Library, and Academic Google databases for articles up to February 2021. The Cochrane risk‐of‐bias tool for randomized clinical trials was used and revealed that the studies included presented low risk of bias for the majority of criteria assessed. It was selected 25 articles, of which only six did not demonstrate positive effects and three presented null effects with the use of melatonin. Melatonin has improved the inflammatory response in periodontal disease, dental surgeries, and mucositis of head and neck oncologic irradiated patients. In addition, it showed anxiolytic potential in patients that were submitted to dental procedures. In conclusion, melatonin favored the treatment of oral changes when used topically and systemically.

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Section: Resultsmentioning

confidence: 99%

Section: Results Of the Studies According To The Specific Dental Cond...mentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Melatonin as an adjunctive treatment on dental procedures: A systematic review

et al. 2021

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Melatonin for preoperative and postoperative anxiety in adults

Madsen

Zetner

Møller

et al. 2020

Cochrane Database of Systematic Reviews

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Controle da ansiedade com benzodiazepínicos em cirurgias de terceiros molares inferior: revisão sistemática

Tejada¹

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Dedico este trabalho à, minha família e ao Ministério do Ensino Superior, Ciência e Tecnologia (MESCYT), que tornou meu sonho realidade ao me permitir e me ajudar a vir ao Brasil e me apoiar financeira e emocionalmente. Sou grato com todos vocês. AGRADECIMENTOS Á Deus: por ser guia e luz nos momentos mais críticos, nas situações difíceis e por abrir portas em cada olhar para a meta. Meus Pais: por serem causa e efeito do meu desejo de estudar, de lutar por um futuro melhor e qualidade de vida. Minha irmã: por me ouvir sempre que preciso, ela é minha orientação e exemplo. MESCYT: por me conceder a bolsa de estudos para o Brasil. Prof. Dr. Flavio Augusto Cardoso: por me dar a oportunidade de ser seu orientado, você é o melhor orientador, professor e amigo dos alunos, muito obrigado. FOB-USP: por me aceitar como aluno e me permitir fazer parte desta grande família. Faviola Polania: por ser colega de classe do meu mestrado, sua colaboração na pesquisa cada momento que necessite de você. A toda equipe da farmacologia da FOB (Prof. Dra. Adriana Calvo, Thiago Jose Dionísio, Elza Araújo Torres, Gabriela de Moraes, Dalva Ribeiro) por me ajudarem em minha pesquisa, graças a sua colaboração hoje estou quase terminando meu mestrado, um grande abraço.

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Should Melatonin Be Used as an Alternative Sedative and Anxiolytic Agent in Mandibular Third Molar Surgery?

Cited by 4 publications

References 19 publications

Melatonin as an adjunctive treatment on dental procedures: A systematic review

Melatonin as an adjunctive treatment on dental procedures: A systematic review

Melatonin for preoperative and postoperative anxiety in adults

Controle da ansiedade com benzodiazepínicos em cirurgias de terceiros molares inferior: revisão sistemática

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