Should FEV 1 /FEV 6 Replace FEV 1 /FVC Ratio To Detect Airway Obstruction?

Jing, Jiyong; Huang, Tongwang; Cui, Wei; Xu, Feng; Shen, Huahao

doi:10.1378/chest.08-0723

Cited by 94 publications

(70 citation statements)

References 43 publications

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“…Hankinson found that differences between FEV6 and FVC values were small in younger adults but increased with age (Hankinson et al, 1999). In our sample, FVC and FEV6 were identical in 42% of the subjects and showed a difference less than 50ml in an additional 55% of the subjects, supporting the view that FEV6 is an acceptable surrogate for the FVC test (Swanney et al, 2000;Pedersen, 2006;Lundgren et al, 2007;Jing et al, 2009).…”

Section: Discussionsupporting

confidence: 76%

“…The FEV6 has also been demonstrated to display less test variability when compared to the FVC (Miller et al, 2005;Vandevoorde et al, 2006). Several studies have shown a sensitivity of 89-95% and a specificity of 97-98% of the FEV6 test compared to FVC (Akpinar-Elci et al, 2006;Pedersen, 2006;Jing et al, 2009). Hankinson found that differences between FEV6 and FVC values were small in younger adults but increased with age (Hankinson et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

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Predictive equations for spirometric reference values in a healthy adult suburban population in Tanzania

Knudsen

Mørkve

Mfinanga

et al. 2011

Tanzania J Hlth Res

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This study was conducted in Kinondoni district, Dar es Salaam, Tanzania, with the objectives to generate prediction equations for forced expiratory volume in 1 second (FEV1), forced expiratory volume in 6 seconds (FEV6), FEV1/FEV6 ratio and peak expiratory flow (PEF) from a nonsymptomatic sample of the population, and to compare these equations to published reference values. The study included adults aged ≥ 15 years who were recruited by use of community based, multistage cluster random sampling. Participants performed spirometry and answered questionnaires regarding respiratory symptoms and socioeconomic conditions. Anthropometric data were collected. Selection of subjects for generation of reference values followed American Thoracic Society (ATS) recommendations. Data were analyzed using multiple regression techniques. Fifty two men and 98 women were selected to the reference value group. FEV1, FEV6, FEV1/FEV6 and PEF were regressed against age, height and weight. For men a curvilinear model was chosen when predicting FEV1, FEV6 and PEF, and a linear model predicted FEV1/FEV6. For women a linear model was used in the regression equations. The reference values generated from our study were lower than in several previously published studies. Our study suggests that assessment of respiratory function should be based on reference values generated from the same population as those being assessed. ______________________________________________________________________________________

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Predictive equations for spirometric reference values in a healthy adult suburban population in Tanzania

Knudsen

Mørkve

Mfinanga

et al. 2011

Tanzania J Hlth Res

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“…It has already been reported that FEV6 is a reliable alternative for FVC to identify restrictive and obstructive spirometric patterns (3)(4)(5)(6)(7)(8)(9)(10)(11). However, to date, no reference values of FEV6 in Japanese have been available due to lack of the community-based epidemiological research.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, FEV6 is becoming a substitute for FVC (3)(4)(5)(6)(7)(8)(9)(10)(11). The merits of utility of FEV6 are: 1) reducing the examination time for the physicians or laboratory technicians, and 2) reducing excess efforts for the subjects.…”

Section: Introductionmentioning

confidence: 99%

FEV6 and FEV1/FEV6 in Japanese Participants of the Community-Based Annual Health Check: The Takahata Study

et al. 2011

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Background Forced expiratory volume in 6 seconds (FEV6) is becoming a substitute of forced vital capacity (FVC). However, the Japanese predictive equation for FEV6 has not been established, and the validity for the use of FEV1/FEV6 for diagnosing airflow limitation in Japanese has not been confirmed. Methods Subjects aged 40 or older, who had participated in a community-based health check in Takahata, Japan, from 2004 through 2005, were enrolled. The smoking histories of these subjects were investigated using a self-reporting questionnaire. FVC, FEV1, and FEV6 were measured using spirometric machines. Predictive equations of FEV6 were obtained from never-smoking subjects without history of pulmonary diseases by multiple linear regression assay. Results FEV6 and FEV1/FEV6 were significantly correlated with FVC (r=0.998, p<0.001) and FEV1/FVC (r=0.989, p<0.001), respectively. The cutoff values of percent predicted (%) FEV6 and FEV1/FEV6 for discrimination of having the restrictive lung disorder determined by %FVC <0.8 and having the airflow limitation determined by FEV1/FVC <0.7 were 0.80 and 0.72, respectively (%FEV6: sensitivity=0.995, specificity= 0.983, positive predictive value =0.832, negative predictive value =1.000; FEV1/FEV6: sensitivity=0.942; specificity=0.971; PPV=0.787; NPV=0.993). When the 5th percentile the lower limit of normal values was used as criterion for discrimination of having airflow limitation, sensitivity, specificity, PPV, and NPV of FEV1/FEV6 were 0.932, 0.985, 0.808, and 0.995, respectively. Conclusion The results of the present study suggest that %FEV6 and FEV1/FEV6 are excellent substitutes for %FVC and FEV1/FVC, respectively. We confirmed the validity of the use of FEV6 and FEV1/FEV6 for identifying pulmonary diseases in Japanese individuals.

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“…Immediately, articles published in the Brazilian Journal of Pulmonology began to be cited by foreign authors in various international journals. A good example of this is the article authored by Lundgren et al, (1) which was cited in the meta-analysis authored by Jing et al (2) In addition, foreign lecturers at international conferences have mentioned articles published in the Brazilian Journal of Pulmonology. In 2009, for instance, the articles authored by Saad Jr. et al (3) and de Moritz et al (4) were cited at the American Thoracic Society Conference and the European Respiratory Society Conference, respectively.…”

mentioning

confidence: 99%

Um patrimônio científico nacional

Martinez

2009

J. bras. pneumol.

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Should FEV 1 /FEV 6 Replace FEV 1 /FVC Ratio To Detect Airway Obstruction?

Cited by 94 publications

References 43 publications

Predictive equations for spirometric reference values in a healthy adult suburban population in Tanzania

Predictive equations for spirometric reference values in a healthy adult suburban population in Tanzania

FEV6 and FEV1/FEV6 in Japanese Participants of the Community-Based Annual Health Check: The Takahata Study

Um patrimônio científico nacional

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