Should every patient diagnosed with a phaeochromocytoma have a ¹²³I‐MIBG scintigraphy?

Abstract

Localization of phaeochromocytomas and paragangliomas (PPGLs) should involve functional imaging as anatomical imaging modalities can either fail to locate the tumour or can be suboptimal due to an anatomical abnormality or previous surgery. Functional imaging is particularly useful to fully delineate the extent of disease using the whole-body scan and the evaluation of multifocality, metastatic or recurrent disease. An increasing number of radiolabeled tracers have become available for tumour visualization during the past decade. (123) I-meta-iodobenzylguanidine scintigraphy is the most widely used functional imaging modality, and its sensitivity to identify chromaffin cell tumours varies from 85 to 88% for phaeochromocytomas and 56-76% for paragangliomas, while specificity ranges between 70 and 100% and 84-100%, respectively.

Role of DOTATATE‐PET/CT in preoperative assessment of phaeochromocytoma and paragangliomas

“…15 Functional imaging comes into its own in 6 particular scenarios: The smallest PC DOTATATE-PET correctly identified in primary assessment was 19 mm and secondary assessment; 10 mm (local recurrence). Previous studies have shown that MIBG is insensitive to these small PCs (reviewed in 25 ). In our series, 9/12 PCs that had both MIBG and DOTATATE-PET scans were positive only on PET.…”

Elektrochemische Synthese von Aryliodiden durch anodische Iododesilylierung

“…[12] Wirv erwendeten das Boc-geschützte Substrat 5,d aw ir aus dem Kompatibilitätstest erkannten, dass primäre Amine nicht kompatibel mit den Reaktionsbedingungen sind (Schema 3). Zusätzlich sind funktionelle Gruppen, die eine intrinsische Reaktivitätg egenüber Iodonium-Ionen Um eine potentielle Anwendungsmçglichkeit zu demonstrieren, untersuchten wir zum Abschluss die Iododesilylierung von Boc-geschütztem 3-Trimethysilylbenzylguanidin 5, welches in der Boc-entschützten Va riante als 121 I-markierte Verbindung in der SPECT-Tomographie Verwendung findet; das 129 I-Derivat wird als Tu mortherapeutikum genutzt.…”

“…[12] Wirk onnten zeigen, dass die Synthese von Aryliodiden durch elektrochemische Iododesilylierung eine atomçkonomische Alternative darstellt, die lediglich Schwefelsäure im Kathodenraum verwendet, um die Leitfähigkeit zu erhçhen. [12] Wirk onnten zeigen, dass die Synthese von Aryliodiden durch elektrochemische Iododesilylierung eine atomçkonomische Alternative darstellt, die lediglich Schwefelsäure im Kathodenraum verwendet, um die Leitfähigkeit zu erhçhen.…”

Semiquantitative 123I-Metaiodobenzylguanidine Scintigraphy to Distinguish Pheochromocytoma and Paraganglioma from Physiologic Adrenal Uptake and Its Correlation with Genotype-Dependent Expression of Catecholamine Transporters

“…Intracellularly, MIBG is stored in neurosecretory granules through the action of vesicular monoamine transporters (VMATs) (2,3). MIBG has proven to be useful for scintigraphic imaging of pheochromocytomas and paragangliomas (PPGLs) (4,5). These rare and often benign catecholamine-producing tumors arise from the adrenal medulla and extraadrenal sympathetic chromaffin tissues (5).…”

“…At present, scintigraphy with 123 I-MIBG is the most commonly used functional imaging technique for localizing PPGLs because of its high specificity and worldwide availability (4,5). Its whole-body exploration makes it particularly useful for the evaluation of multifocality and metastatic and recurrent disease.…”