Shotgun Characterization of the Circulating IgM Antigenome of an Infectious Pathogen by Immunocapture-LC–MS/MS from Dried Serum Spots
Paloma Abad,
Montserrat Coronado,
África Vincelle-Nieto
et al.
Abstract:One
of the main challenges in compiling the complete collection
of protein antigens from pathogens for the selection of vaccine candidates
or intervention targets is to acquire a broad enough representation
of them to be recognized by the highly diversified immunoglobulin
repertoire in human populations. Dried serum spot sampling (DSS) retains
a large repertoire of circulating immunoglobulins from each individual
that can be representative of a population, according to the sample
size. In this work, shotgun pr… Show more
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