Abstract:Developing chemical tools to detect and influence biological processes in complex systems is a cornerstone of the field of chemical biology. Here we combine two tools which rely on orthogonality– perfluorocarbons and multiplexed shortwave infrared fluorescence imaging– to track the biodistribution of nanoemulsions in real time in living mice. Drawing inspiration from fluorous and shortwave infrared (SWIR) fluorophore development, we prepared two SWIR-emissive chromenylium polymethine dyes that are soluble in p… Show more
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