Shorter Remission Period in Young Versus Older Children with Diabetes Mellitus Type 1

Dost, Axel; Herbst, Antje; Kintzel, K; Haberland, Holger; Roth, Christian; Gortner, Ludwig; Holl, Reinhard W.

doi:10.1055/s-2007-948214

Cited by 42 publications

(52 citation statements)

References 16 publications

(13 reference statements)

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“…Our results show disparity to other studies in some aspects. These may be explained, in part, by different age cutoff used in our study, being<10 years, instead of 5 years like in some studies [4,14,22,27]. Adolescents constituted the majority in the older group (>10 years) with higher insulin dose requirement due to insulin resistance seen during adolescent years, and low compliance rates in this age group may also explain the lower remission rates compared with the younger group.…”

Section: Discussionmentioning

confidence: 48%

“…Neylonet al [25] reported that this definition was a practical method in the clinical applications, and they added it on a computer based algorithm to predict which patients with partial remission will require a dose increase of insulin before next evaluation. In different studies partial remission rates were reported to be between 11.0 and 68.7 % [19,[24][25][26][27][28]. The wide range in dispersal of partial remission rates within studies is probably a reflection of variability in the employed diagnostic measurements.…”

Section: Discussionmentioning

confidence: 88%

“…Studies investigating correlations between partial remission and age have shown dissimilar results because of the different methods used. In some studies, it was reported that partial remission frequency was lower in children younger than 5 years of age [4,14,22,27]. Böber et al [19] did not define any differences in partial remission rate in between children over and below 10 years of age.…”

Section: Discussionmentioning

confidence: 97%

“…It has been reported that partial remission is more common in males when compared with females, and beta cell destruction is more common in females during adolescence [20,27,37]. It has been proposed that higher insulin sensitivity and lower insulin requirement in males may lead to more frequent observations of partial remissions [38,39].…”

Section: Discussionmentioning

confidence: 97%

“…When our study was evaluated for partial remission rate, no significant difference was observed in gender distribution between the groups. Similarly, no correlation was determined between partial remission rate and gender in some studies related to the topic in the literature [4,22,27,28].…”

Section: Discussionmentioning

confidence: 99%

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Frequency of partial remission and related factors in children and adolescents diagnosed with type 1 diabetes mellitus

Esen

Demirel

Tepe

et al. 2015

Int J Diabetes Dev Ctries

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The aim of this study was to determine the frequency of remission and related factors in children and adolescents with T1DM. The medical files of patients, diagnosed at our clinic with T1DM in a sequential 3-year period and followed up for at least one year, were retrospectively reviewed. Measurements of pH, blood glucose, insulin, C-peptide, HbA1c and diabetes related auto-antibodies were recorded at diagnosis along with presence of diabetic keto-acidosis and daily insulin requirements at initial discharge. Subsequent HbA1c values and daily insulin requirements were recorded at follow up visits. Partial remission was defined as the value of adjusted HbA1c of≤9. Adjusted HbA1c is equal to HbA1c (percent)+[4 x insülin dose (units per kilograms per day)]. Patients were evaluated according to age groups (group 1≤ 10 years; Group 2>10 years). Data of 111 patients (males= 56) were evaluated [mean age 9.4±4.2 years (0.8-16.2)]. Complete remission was observed in none of our patients. Partial remission was observed in 67 patients (60.4 %), and partial remission was observed more frequently in children≤ 10 years of age (p=0.043). No correlation was identified between clinical and laboratory characteristics at the time of diagnosis and frequency of partial remission. The frequency of partial remission was higher in younger children during the period of observation. Additionally, clinical and laboratory characteristics at the time of diagnosis were not helpful in predicting the degree of remission in this study group.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Frequency of partial remission and related factors in children and adolescents diagnosed with type 1 diabetes mellitus

Esen

Demirel

Tepe

et al. 2015

Int J Diabetes Dev Ctries

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The remission phase in type 1 diabetes: Changing epidemiology, definitions, and emerging immuno‐metabolic mechanisms

Zhong

Tang

Gong

et al. 2019

Diabetes Metabolism Res

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Type 1 diabetes mellitus (T1DM) is characterized by irreversible islet β cell destruction. During the progression of this disease, some patients with T1DM experience a phase of remission known as honeymoon or partial remission (PR) that is mainly characterized by satisfactory glycemic control and the transient recovery of islet β cell function. This special phase is a good model for studying the mechanism of β cell protection, might serve as a proper intervention period for immunotherapy, and may be related to disease prognosis. This special stage is highly valuable for studies aiming to identify possible targets that may be used to cure T1DM. An in-depth understanding of the diagnosis, epidemiology, and possible mechanisms of the PR phase is highly needed. In general, patients enter the PR phase approximately 3 months after starting insulin therapy, and this phase could be sustained for 6 to 9 months. Current research increasingly focuses on the metabolic and immunological aspects to constantly update our understanding of this phase. This review concentrates on the PR phase of T1DM to provide a comprehensive outlook of its epidemiology, diagnostic criteria, and underlying immune metabolic mechanisms. KEYWORDSimmuno-metabolic mechanism, remission phase, the honeymoon period, type 1 diabetes

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Current literature in diabetes

2007

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Shorter Remission Period in Young Versus Older Children with Diabetes Mellitus Type 1

Abstract: These data from a large multicenter group of children with diabetes type 1 emphasize the influence of gender, pubertal stage and age at manifestation on the amount of insulin required, and therefore the clinical remission, during the first three years of the disease.

Cited by 42 publications

References 16 publications

Frequency of partial remission and related factors in children and adolescents diagnosed with type 1 diabetes mellitus

Frequency of partial remission and related factors in children and adolescents diagnosed with type 1 diabetes mellitus

The remission phase in type 1 diabetes: Changing epidemiology, definitions, and emerging immuno‐metabolic mechanisms

Current literature in diabetes

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