Shorter notice. The Metropolis and its Image: Constructing Identities for London, c. 1750-1950. D Arnold [ed]

Borg, Alan

doi:10.1093/enghis/115.462.741

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“…Also, both drugs photosensitized the peroxidation of linoleic acid, suggesting a predominant involvement of radical species. The IPA-radical (IPA • ) formation was originally observed by Borg using anodic electrolysis and paramagnetic resonance, who assigned to it absorption maxima at 261 and 640 nm . The participation of IPA • in the photodestruction mechanism of CIPA was proposed by Canudas and Contreras .…”

Section: Introductionmentioning

confidence: 95%

Photophysics and Photochemistry of Imipramine, Desimipramine, and Clomipramine in Several Solvents: A Fluorescence, 266 nm Laser Flash, and Theoretical Study

et al. 2007

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Imipramine (IPA) and its derivatives are used widely for the treatment of depression and other mental disorders. Although there are more than 20 FDA-approved antidepressant drugs, the search continues for better compounds with fewer deleterious side effects and higher efficacy. Over the past decade, several classes of antipsychotic drugs have been developed, which-in spite of their structural diversity-share an ability to modulate neurotransmission and to produce undesirable side effects. Phototoxicity is one of the most important side effects noted in treatment with tricyclic antidepressants (TCAs), but its mechanism has not yet been elucidated. To develop new knowledge regarding the relationship between the structure and the photophysics of these TCAs, we measured the photophysical properties of IPA, desimipramine (DIPA), and clomipramine (CIPA) in different solvents. The electronic configurations for the ground and the first excited singlet states were calculated using the AM1/RHF/CI and the AM1/RHF/HE semiempirical quantum theoretical methods, respectively. The ground-state properties are solvent-independent, while the emission maxima are red-shifted with increasing solvent polarity/polarizability. However, the fluorescence quantum yield is relatively low in all of the tested solvents (phif<0.02). The primary transient intermediates produced by 266 nm high-intensity laser photolysis are the solvated electron and the corresponding radical cation, with a negligible contribution of triplet-triplet absorption. The properties determined for the primary transients generated with a 266 nm laser flash are consistent with the photodamaging effects generated through a limited radical mechanism.

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Section: Introductionmentioning

confidence: 95%