Shorter leukocyte telomere length is associated with risk of nonobstructive azoospermia

Yang, Qingling; Luo, Xiaoyan; Bai, Rui; Zhao, Fei; Dai, Shanjun; Li, Fangyuan; Zhu, Jing; Liu, Jinhao; Niu, Wenbin; Sun, Yingpu

doi:10.1016/j.fertnstert.2018.05.008

Cited by 10 publications

(9 citation statements)

References 48 publications

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“…Similarly, longer leukocyte TL in 10 fertile men than in 10 oligozoospermic patients was reported by Amirzadegan et al 25 . On the other hand, Yang et al 37 . reported shorter leukocyte TL in 349 non‐obstructive azoospermia patients than in 247 obstructive azoospermia patients and 270 normospermic men, and results from the Tahamtan et al 30 .…”

Section: Resultsmentioning

confidence: 58%

“…Regarding TL in leukocytes, three studies reported lower leukocyte TL in infertile patients than in fertile men. 24,28,36 Similarly, longer leukocyte TL in 10 fertile men than in 10 oligozoospermic patients was reported by Amirzadegan et al 25 On the other hand, Yang et al 37 reported shorter leukocyte TL in 349 nonobstructive azoospermia patients than in 247 obstructive azoospermia patients and 270 normospermic men, and results from the Tahamtan et al 30 study showed significantly lower leukocyte TL in men with infertility resulting from varicocoele than fertile controls. Only two studies found no differences in leukocyte TL between normozoospermic and oligozoospermic men 14 or between fertile and infertile subjects.…”

Section: Differences In Leukocyte Tl Between Fertile and Infertile Or...mentioning

confidence: 67%

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Is telomere length a biomarker of sperm quality? A systematic review and meta‐analysis of observational studies

et al. 2023

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BackgroundTelomeres are essential for the integrity of chromosome ends during cell division and their involvement in different processes linked to aging has been established. These chromosome components are involved in spermatogenesis and seem to play an important role in fertilization and embryo development. Telomere length is shortened with each cell division. Recently, short sperm telomere length has been proposed as a potential biomarker of male infertility.ObjectivesTo conduct a systematic review and meta‐analysis of studies exploring the association between spermatozoa and/or leukocyte telomere length with sperm quality parameters and different infertility conditions.Material and methodsA systematic review and meta‐analysis was conducted with studies from Medline‐PUBMED and Cochrane Library databases until May 2022. Eligible studies included cohort, cross‐sectional and case–control studies, and telomere length in spermatozoa and/or leukocytes cells was defined as the exposure. Semen quality parameters or infertility conditions (e.g., oligozoospermia, asthenozoospermia, teratozoospermia, or other spermatogenic impairment combinations) were defined as the outcomes.ResultsTwenty‐three observational studies were included. In the qualitative analysis, high heterogeneity was observed between studies regarding the associations between telomere length and semen parameters in different normozoospermic/fertile and oligozoospermic/infertile populations. In the meta‐analysis, spermatozoa and leukocyte telomere length were shorter in infertile individuals than in fertile individuals (mean difference [95% confidence interval]: –1.43 [–1.66 to –1.21], p‐value <0.001 and –1.67 [–2.02 to –1.31], p‐value <0.001, respectively). Moreover, in terms of sperm telomere length, these differences were also significant between individuals with a normal seminogram and individuals with a low quantity of spermatozoa in the ejaculate (–0.97 [–1.32, –0.61], p‐value <0.001).ConclusionThe current systematic review and meta‐analysis suggests the potential role of spermatozoa or leukocyte telomere length as a reliable biomarker of semen quality, which may help distinguish between infertility conditions beyond the routine semen analysis.

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Section: Resultsmentioning

confidence: 58%

Section: Differences In Leukocyte Tl Between Fertile and Infertile Or...mentioning

confidence: 67%

Is telomere length a biomarker of sperm quality? A systematic review and meta‐analysis of observational studies

et al. 2023

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“…Moreover, samples that were used for IVF and had abnormal STLs did not produce a successful pregnancy, whereas samples that had STLs within the normal range had a 35.7% success rate (79). Likewise, males with azoospermia exhibited a shortened STL (69,70), as well as a shorter LTL (85,86).…”

Section: Telomere Length and Male Infertilitymentioning

confidence: 98%

“…A positive association between male infertility factors and TL was observed in 19 studies (68-86) and a negative association in 2 studies (39,87) (Table II). In total, 15 of the positively associated studies detected a sperm TL (STL) association (68-70,72,74-84), while 3 studies detected an LTL association (73,85,86), and one study detected both STL and LTL (71). In several studies, shorter STL was reported in association to infertility (72,76,78,80) while Vecoli et al reported an increase in STL in areas of high environmental exposure (77).…”

Section: Telomere Length and Male Infertilitymentioning

confidence: 99%

The association of female and male infertility with telomere length (Review)

et al. 2019

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Telomere length (TL) has long been associated with aging, as telomeres serve as protective caps of chromosomes, and are thus deeply involved in the preservation of genome integrity and are vital to cellular functions. Traditionally, a strong link connects aging and infertility in both sexes, with an earlier onset in females. Over the past decade, telomeres have attracted increasing attention due to the role they play in fertility. In this review, we investigated the potential positive or negative association between relative TL and different factors of female and male infertility. A systematic search of the PubMed database was conducted. Out of the 206 studies identified, 45 were reviewed as they fulfilled the criteria of validity and relevance. Following an analysis and a comparison of the study outcomes, several clear trends were observed. The majority of female infertility factors were associated with a shorter TL, with the exception of endometriosis, premature ovarian failure and clear cell carcinoma that were associated with a longer TL and polycystic ovary syndrome (PCOS), which revealed conflicting results among several studies, leading to ambiguous conclusions. Male infertility factors were associated with a shorter TL. Although this review can provide an outline of general trends in the association of TL with infertility factors, further epidemiological and original research studies are required to focus on investigating the basis of these varying lengths of telomeres. Contents 1. Introduction 2. Telomere length and female infertility 3. Telomere length and male infertility 4. Conclusions and future perspectives

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“…Liu et al found that fertilization of telomerase-de cient spermatozoa with wild-type oocytes resulted in decreased fertilization and blastocyst formation rates, increased embryo fragmentation, and increased cell apoptosis [43]. However, there're also some studies didn't con rm this result [45],[46],[48], [49]. A meta-analysis involving 60 samples found that there was a weak correlation between sperm telomere length (STL) variation and lower fertilization rate [rho-Spearman coe cient is -0.04(95% CI, -0.203-0.113; p = 0.57)] [45].…”

Section: Discussionmentioning

confidence: 99%

Telomere length and the risk of infertility: A Mendelian randomization study

qu,

liu,

et al. 2023

Preprint

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Purpose As people age, fertility tends to decline, and various previous studies have indicated a potential connection between aging and infertility. However, whether telomere length (TL), as a marker of cellular age, is causally related to infertility remains an unknown question. Methods In this research, we performed two-sample Mendelian randomization (MR) study to evaluate the causal relationship between TL and infertility risk. We mainly conducted MR analyses employing the inverse variance weighted (IVW) method and complemented with other MR methods. Additionally, sensitivity analysis was performed to testify the primary results' robustness. Results The summary dataset of the genome-wide association studies (GWAS) for TL (n = 472,174) were obtained from the UK Biobank. Four infertility subgroups based on gender and etiology were selected from FinnGen Consortium R6 release, which included 119,206 (Female infertility_1), 118,644 (Female infertility_2) ,128,432 (Female infertility_3) and 74,159 (Male infertility) individuals, respectively. 137 single-nucleotide polymorphisms (SNPs) associated with TL in European populations were selected as instrumental variables (IVs). We found that genetically determined TL and epigenetic clocks were not individually associated with 4 types infertility(IVW p > 0.05), and this result was consistent across sensitivity analyses. Our findings indicate that there was no causal association between genetically determined TL and epigenetic clocks with the four types of infertility (IVW p > 0.05). Other methods also achieved consistent results. Sensitivity analyses were performed and revealed no heterogeneity and horizontal pleiotropy. Conclusions Our findings suggest that TL may not serve as effective causal biomarkers for predicting infertility and need more robust analytical methods and more comprehensive researches.

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Shorter leukocyte telomere length is associated with risk of nonobstructive azoospermia

Abstract: This is the first report that short LTL is associated with NOA, shedding light on an important biological pathway involved in the etiology of this form of male factor infertility.

Cited by 10 publications

References 48 publications

Is telomere length a biomarker of sperm quality? A systematic review and meta‐analysis of observational studies

Is telomere length a biomarker of sperm quality? A systematic review and meta‐analysis of observational studies

The association of female and male infertility with telomere length (Review)

Telomere length and the risk of infertility: A Mendelian randomization study

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