Shortening rCBF Measurement Interval in [15O]H2O PET

Watabe, Hiroshi; Kondoh, Yuusuke; Kim, Kyeong Min; Shidahara, Miho; Iida, Hidehiro

doi:10.1016/b978-012636651-8/50032-5

Cited by 1 publication

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References 12 publications

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“…Another application of this approach is the repeat assessment of CBF. Watabe et al (2002) showed that CBF images can be quantitated at much shorter interval than the previous protocol, typically at 90 secs, from sequential PET scanning Altman et al (1991) obtained OEF values of 0.5370.13 from arteriosinus blood sampling. Using steady-state PET, others have measured OEFs ranging from 0.42 to 0.58 in normal tissues of anesthetized monkeys (Altman et al, 1991;Pappata et al, 1993;Touzani et al, 1995;Young et al, 1996;Schumann et al, 1996;Frykholm et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Kudomi

Hayashi

Teramoto

et al. 2005

J Cereb Blood Flow Metab

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Cerebral blood flow (CBF) and rate of oxygen metabolism (CMRO 2 ) may be quantified using positron emission tomography (PET) with 15 O-tracers, but the conventional three-step technique requires a relatively long study period, attributed to the need for separate acquisition for each of 15 O 2 , H 2 15 O, and C 15 O tracers, which makes the multiple measurements at different physiologic conditions difficult. In this study, we present a novel, faster technique that provides a pixel-by-pixel calculation of CBF and CMRO 2 from a single PET acquisition with a sequential administration of 15 O 2 and H 2 15 O. Experiments were performed on six anesthetized monkeys to validate this technique. The global CBF, oxygen extraction fraction (OEF), and CMRO 2 obtained by the present technique at rest were not significantly different from those obtained with three-step method. The global OEF (gOEF) also agreed with that determined by simultaneous arterio-sinus blood sampling (gOEF AÀV ) for a physiologically wide range when changing the arterial PaCO 2 (gOEF ¼ 1.03gOEF AÀV þ 0.01, Po0.001). The regional values, as well as the image quality were identical between the present technique and three-step method for CBF, OEF, and CMRO 2 . In addition, a simulation study showed that error sensitivity of the present technique to delay or dispersion of the input function, and the error in the partition coefficient was equivalent to that observed for three-step method. Error sensitivity to cerebral blood volume (CBV) was also identical to that in the three-step and reasonably small, suggesting that a single CBV assessment is sufficient for repeated measures of CBF/CMRO 2 . These results show that this fast technique has an ability for accurate assessment of CBF/CMRO 2 and also allows multiple assessment at different physiologic conditions.

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Section: Discussionmentioning

confidence: 99%

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Kudomi

Hayashi

Teramoto

et al. 2005

J Cereb Blood Flow Metab

Self Cite

101

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Shortening rCBF Measurement Interval in [15O]H2O PET

Cited by 1 publication

References 12 publications

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

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Shortening rCBF Measurement Interval in [15O]H2O PET

Cited by 1 publication

References 12 publications

Rapid Quantitative Measurement of CMRO2 and CBF by Dual Administration of 15O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Rapid Quantitative Measurement of CMRO2 and CBF by Dual Administration of 15O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

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Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys