Shortened activated partial thromboplastin time, a hemostatic marker for hypercoagulable state during acute coronary event

Abdullah, Wan Zaidah; Moufak, Shaimaa K.; Yusof, Zurkurnai; Mohamad, Mohd Sapawi; Kamarul, I. M.

doi:10.1016/j.trsl.2010.02.001

Cited by 29 publications

(21 citation statements)

References 9 publications

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“…APTT and PT are a qualitative measurement of factors involved in the intrinsic and extrinsic pathways respectively (Salawu et al, 2008;Bamidele et al, 2010;Cipil et al, 2009). The increase in APTT and/or PT could be due to, a deficiency of, or an inhibitor to, any of the clotting factors involved in either pathways or in the final step of the clotting pathway (Abdullah et al, 2010). The observed increase in clotting time, PT and APTT occurred at a doses between 100-500 mg kg −1 but not with higher doses indicate that this effect is probably not a toxicity and may have a therapeutic potential as anticoagulant and warrant further investigation.…”

Section: Discussionmentioning

confidence: 99%

Acute and Sub-acute Toxicity of <i>Crataegus Aronia Syn. Azarolus</i> (L.) Whole Plant Aqueous Extract in Wistar Rats

Shatoor¹

2011

American Journal of Pharmacology and Toxicology

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Problem statement: Hawthorn comprises more than 200 species worldwide but very few species have been used medicinally. In Mediterranean region, the predominant species of the genus Crataegus is C. aronia syn. Azarolus (L). The extracts or tinctures prepared from the leaves, flowers and/or a fruit has been used traditionally for the treatment of different diseases including different cardiovascular problems. This species (C. aronia syn. Azarolus (L.)) has not been adequately studied. Thus, we aimed to investigate for the possible acute and sub-acute toxicity of C. aronia syn. Azarolus (L.) on Wistar albino rats. Approach: The phytochemical screening of the aqueous extract of C. aronia syn. Azarolus (L.) was determined. Athirty six Wistar rats of both sexes weighing 180-200 g. were divided randomly into sex groups of 6 rats each. The first group was the control group and fed with equal volume of distilled water, while the other 5 groups were given single daily dose of the aqueous extract per os at different doses (100, 200, 500, 1000 and 2000 mg kg

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Section: Discussionmentioning

confidence: 99%

Acute and Sub-acute Toxicity of <i>Crataegus Aronia Syn. Azarolus</i> (L.) Whole Plant Aqueous Extract in Wistar Rats

Shatoor¹

2011

American Journal of Pharmacology and Toxicology

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“…Patients with atrial fibrillation who are not on anticoagulants have a risk of stroke ranging from ϳ2% to 19% per year depending on age and comorbidities. 13 It has been estimated that there are Ͼ50 000 preventable strokes per year in the United States. Key clinical trials have shown that, at least in the population under study, the NOACs are as effective as warfarin in preventing strokes in patients with atrial fibrillation and are associated with a lower risk of lifethreatening bleeding than warfarin.…”

Section: Do We Really Need Antidotes For Noacs?mentioning

confidence: 99%

Reversing targeted oral anticoagulants

Hoffman

Monroe

2014

Hematology

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Dabigatran, rivaroxaban, and apixaban are orally active anticoagulants that are approved in many countries. Dabigatran inhibits thrombin, whereas rivaroxaban and apixaban are factor Xa inhibitors. In clinical trials, these novel oral anticoagulants were at least as effective as warfarin for preventing stroke in patients with atrial fibrillation, but with a lower rate of serious bleeding. However, the lack of true antidotes for these agents has caused concern when patients suffer life-threatening bleeding or trauma or require emergent invasive procedures. True antidotes are under development for all of these agents. In the meantime, activated and nonactivated prothrombin complex concentrates have been used as reversal agents. Factor VIIa may also be effective for reversal of the factor Xa inhibitors. Reversal of novel oral anticoagulants by these hemostatic agents has not been studied in bleeding human patients, so their true efficacy and appropriate dosing are not known. Learning Objective• To understand the currently available options for enhancing hemostasis in a patient on one of the targeted oral anticoagulants

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“…Elevated FVIII levels and probably other coagulation factors play a pathogenic role in the mechanism of abnormally shortened APTT during acute coronary event or related to venous thrombosis (Abdullah WZ et al, 2010;Tripodi et al, 2004)). Hence in arterial thrombosis, presence of high coagulation factors (particularly FVIII) and positive APC-R assay were found similar to the reported findings in venous thrombosis.…”

Section: Haemostasis and Laboratory Investigationsmentioning

confidence: 99%

“…In one study, shortened APTT was significantly different in ACS patients compared to stable coronary artery disease patients (SCAD) when they presented early to the hospital (Abdullah WZ., et al 2010). High FVIII levels were also found to be significant in ACS patients compared to the SCAD group.…”

Section: Haemostasis and Coronary Artery Diseasementioning

confidence: 99%

Shortened Activated Partial Thromboplastin Time (APTT): A Simple but Important Marker of Hypercoagulable State During Acute Coronary Event

Abdullah¹

2012

Coronary Artery Disease - New Insights and Novel Approaches

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Shortened activated partial thromboplastin time, a hemostatic marker for hypercoagulable state during acute coronary event

Cited by 29 publications

References 9 publications

Acute and Sub-acute Toxicity of <i>Crataegus Aronia Syn. Azarolus</i> (L.) Whole Plant Aqueous Extract in Wistar Rats

Acute and Sub-acute Toxicity of <i>Crataegus Aronia Syn. Azarolus</i> (L.) Whole Plant Aqueous Extract in Wistar Rats

Reversing targeted oral anticoagulants

Shortened Activated Partial Thromboplastin Time (APTT): A Simple but Important Marker of Hypercoagulable State During Acute Coronary Event

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