Short-wave Photoacoustic Lipid Imaging (SW-PALI) for Detection of early-onset Alzheimer's Disease

Salinas, Christopher M.; Reichel, Eric; Witte, Russell S.

doi:10.1109/ius54386.2022.9957485

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…A limitation of this study was that no direct validation with histology was performed to quantify the presence of LWC. Studies which implement spectral-unmixing algorithms 24 , 45 – 48 to identify LWC and other constituents in tissue may find a benefit in the increased SNR at chosen wavelengths provided through HWG; however, future validation studies are needed to determine the accuracy of these HWG-enabled spectral unmixing algorithms in the SWIR. One potential drawback of heavy water coupling is its relatively high cost compared to regular water that primarily depends on purity and volume.…”

Section: Discussionmentioning

confidence: 99%

“…Techniques that employ PAI in the SWIR have previously demonstrated capability to probe lipid and collagen changes in diseases such as atherosclerosis and cancer 21 , 22 . While lipid and collagen profiles in these diseases are well documented, rigorous quantification of lipid changes during Alzheimer’s progression is an ongoing endeavor 23 , 24 that SWIR PAI could address 25 , 26 . However, the strong optical absorption of traditional optical and acoustic coupling media (e.g., water, oils, and rubbers) above 1200 nm have posed a significant challenge for reflection-mode (i.e., light and sound delivery from the same direction) PAI in the SWIR, which is desirable for in vivo imaging 27 …”

Section: Introductionmentioning

confidence: 99%

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Heavy water coupling gel for short-wave infrared photoacoustic imaging

Salinas,

Reichel,

Gupta

et al. 2023

J. Biomed. Opt.

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Significance: Changes in lipid, water, and collagen (LWC) content in tissue are associated with numerous medical abnormalities (cancer, atherosclerosis, and Alzheimer's disease). Standard imaging modalities are limited in resolution, specificity, and/or penetration for quantifying these changes. Short-wave infrared (SWIR) photoacoustic imaging (PAI) has the potential to overcome these challenges by exploiting the unique optical absorption properties of LWC > 1000 nm.Aim: This study's aim is to harness SWIR PAI for mapping LWC changes in tissue. The focus lies in devising a reflection-mode PAI technique that surmounts current limitations related to SWIR light delivery.Approach: To enhance light delivery for reflection-mode SWIR PAI, we designed a deuterium oxide (D 2 O, "heavy water") gelatin (HWG) interface for opto-acoustic coupling, intended to significantly improve light transmission above 1200 nm.Results: HWG permits light delivery >1 mJ up to 1850 nm, which was not possible with water-based coupling (>1 mJ light delivery up to 1350 nm). PAI using the HWG interface and the Visualsonics Vevo LAZR-X reveals a signal increase up to 24 dB at 1720 nm in lipid-rich regions.Conclusions: By overcoming barriers related to light penetration, the HWG coupling interface enables accurate quantification/monitoring of biomarkers like LWC using reflection-mode PAI. This technological stride offers potential for tracking changes in chronic diseases (in vivo) and evaluating their responses to therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heavy water coupling gel for short-wave infrared photoacoustic imaging

Salinas,

Reichel,

Gupta

et al. 2023

J. Biomed. Opt.

View full text Add to dashboard Cite

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“…Additionally, the substantial presence of lipid inclusions ascertained from AD patients suggests that lipid peroxidation signifies an early stage in AD development ( Ayala et al, 2014 ; Kao et al, 2020 ). Hence, monitoring lipid content becomes imperative for early AD diagnosis ( Salinas et al, 2022 ). As clinical trials gather more data on AD-related risk factors, there’s an increasing emphasis on early diagnosis and treatment for AD patients.…”

Section: Introductionmentioning

confidence: 99%

Light on Alzheimer’s disease: from basic insights to preclinical studies

Mi,

Liu,

Chen

et al. 2024

Front. Aging Neurosci.

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Alzheimer’s disease (AD), referring to a gradual deterioration in cognitive function, including memory loss and impaired thinking skills, has emerged as a substantial worldwide challenge with profound social and economic implications. As the prevalence of AD continues to rise and the population ages, there is an imperative demand for innovative imaging techniques to help improve our understanding of these complex conditions. Photoacoustic (PA) imaging forms a hybrid imaging modality by integrating the high-contrast of optical imaging and deep-penetration of ultrasound imaging. PA imaging enables the visualization and characterization of tissue structures and multifunctional information at high resolution and, has demonstrated promising preliminary results in the study and diagnosis of AD. This review endeavors to offer a thorough overview of the current applications and potential of PA imaging on AD diagnosis and treatment. Firstly, the structural, functional, molecular parameter changes associated with AD-related brain imaging captured by PA imaging will be summarized, shaping the diagnostic standpoint of this review. Then, the therapeutic methods aimed at AD is discussed further. Lastly, the potential solutions and clinical applications to expand the extent of PA imaging into deeper AD scenarios is proposed. While certain aspects might not be fully covered, this mini-review provides valuable insights into AD diagnosis and treatment through the utilization of innovative tissue photothermal effects. We hope that it will spark further exploration in this field, fostering improved and earlier theranostics for AD.

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Short-wave Photoacoustic Lipid Imaging (SW-PALI) for Detection of early-onset Alzheimer's Disease

Cited by 2 publications

References 7 publications

Heavy water coupling gel for short-wave infrared photoacoustic imaging

Heavy water coupling gel for short-wave infrared photoacoustic imaging

Light on Alzheimer’s disease: from basic insights to preclinical studies

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