Short time impact of different hydroxyethyl starch solutions on the mesenteric microcirculation in experimental sepsis in rats

Wafa, Karim; Herrmann, Adalbert; Kuhnert, T.; Wegner, Annette; Gründling, Matthias; Pavlović, Dragan; Lehmann, Christian

doi:10.1016/j.mvr.2014.07.012

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…The authors also found that less than half of the fluid volume was needed in colloid group when compared to crystalloid to achieve the target macro circulatory parameters. Our results contradict with the results of Wefa et al [41] they reported that HES solutions did not improve microcirculation when compared to crystalloids during fluid resuscitation in sepsis. Intravital microscopy of the mesenteric microcirculation (plasma extravasation; leukocyte-endothelial interactions) and arterial blood gas analysis were performed before and after fluid resuscitation, however, the point to be considered that it was an experimental sepsis model in rats with induced septic peritonitis.…”

Section: Discussioncontrasting

confidence: 99%

Evaluation of two different fluids regimens on central venous-to-arterial Carbon Dioxide difference (pCO ₂ gap) - a randomized controlled trial

Mahrous

Ismail

2021

Egyptian Journal of Anaesthesia

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Section: Discussioncontrasting

confidence: 99%

Evaluation of two different fluids regimens on central venous-to-arterial Carbon Dioxide difference (pCO ₂ gap) - a randomized controlled trial

Mahrous

Ismail

2021

Egyptian Journal of Anaesthesia

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“…We found that leukocyte infi ltration in the lungs of groups treated with 0.9 % NaCl and HES could not be adequately prevented, but treatment with hypertonic saline signifi cantly reduced the content of leukocytes. Supporting this, Oliveira et al suggests that the most interesting benefi cial effect of hypertonic saline is the reduction of SIRS and attenuated MODS, especially in sepsis (29).…”

Section: Discussionmentioning

confidence: 92%

Effect of fluid resuscitation on acute lung injury in a rat model of sepsis

Erdoğan¹,

Erdoğan²,

Kara³

et al. 2021

BLL

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AIM: Sepsis is a systemic infection reaction and intravascular volume therapy plays a crucial role in it's treatment. Acute respiratory distress syndrome (ARDS) occurs in the lungs, the most affected organ. This study aimed to investigate the different effects of fl uid therapy on ARDS caused by sepsis. METHOD: To form a sepsis model, cecal ligation and puncture (CLP) procedure were performed on 44 adult rats. Divided into six groups; normal, CLP group, those treated with 40 ml/kg 0.9 % NaCl, 3 % NaCl (hypertonic saline), Ringer Lactate and Hydroxyethyl starch. After 24 hours treatments, histopathological examination of the lungs were done, and the plasma levels of CRP, TNF-α and IL-6 and paO 2 were measured. RESULTS: The scores of all histological parameters of the group treated with hypertonic saline were signifi cantly lower than of the other groups (p < 0.001). Likewise, according to the arterial blood gas results, paO 2 was signifi cantly higher (p < 0.01) in the hypertonic saline group compared to the other groups, and paCO 2 was signifi cantly lower (p < 0.01). CRP, TNF-α and IL-6 levels of infl ammatory markers were also signifi cantly lower in hypertonic saline groups compared to other groups (p < 0.001). CONCLUSIONS: Our study shows that treatment with hypertonic saline reduces the progression of ARDS in sepsis (Tab.

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Fully Balanced Fluids do not Improve Microvascular Oxygenation, Acidosis and Renal Function in a Rat Model of Endotoxemia

Ergin

Zafrani

Kandil

et al. 2016

Shock

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The expectation of fluid therapy in patients with septic shock is that it corrects hypovolemia, with the aim of restoring tissue perfusion and oxygenation and organ function. This study investigated whether different types of resuscitation fluids were effective in improving renal microcirculatory oxygenation, acidosis, oxidative stress, and renal function in a rat model of endotoxemic shock. Five groups of rats were used: a sham group, a lipopolysaccharide (LPS) group, and three LPS groups that received 30 mL/kg/h of 0.9% sodium chloride (0.9% NaCl), a new bicarbonate buffered crystalloid solution closely resembling the composition of plasma (FB-Cxt) or a hydroxyethyl starch-ringer acetate solution. Systemic hemodynamic variables, renal blood flow, microvascular oxygenation, oxidative/nitrosative stress, and renal function were measured. LPS-induced shock was only partially resolved by fluid administration. Animals became arterially hypotensive despite adequate central venous pressure. Hydroxyethyl starch-ringer acetate was more effective at improving arterial pressures and renal blood flow than 0.9% NaCl or FB-Cxt. Fluids had marginal effects on pH and HCO3 levels irrespective of the buffer, or on renal μPO2 and dysfunction. Colloids increased the markers of renal oxidative stress (P < 0.001), whereas unbalanced crystalloids increased the markers of nitrosative stress during sepsis (P < 0.01). Endotoxemia-induced acidosis and decreases in renal μPO2 or renal injury were not corrected solely by fluid resuscitation, irrespective of the buffer of the fluid. Our study supported the idea that fluids must be supplemented by other compounds that specifically correct renal inflammation and oxygenation to be effective in resolving septic shock-induced renal failure.

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Short time impact of different hydroxyethyl starch solutions on the mesenteric microcirculation in experimental sepsis in rats

Cited by 5 publications

References 13 publications

Evaluation of two different fluids regimens on central venous-to-arterial Carbon Dioxide difference (pCO ₂ gap) - a randomized controlled trial

Evaluation of two different fluids regimens on central venous-to-arterial Carbon Dioxide difference (pCO ₂ gap) - a randomized controlled trial

Effect of fluid resuscitation on acute lung injury in a rat model of sepsis

Fully Balanced Fluids do not Improve Microvascular Oxygenation, Acidosis and Renal Function in a Rat Model of Endotoxemia

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Short time impact of different hydroxyethyl starch solutions on the mesenteric microcirculation in experimental sepsis in rats

Cited by 5 publications

References 13 publications

Evaluation of two different fluids regimens on central venous-to-arterial Carbon Dioxide difference (pCO 2 gap) - a randomized controlled trial

Evaluation of two different fluids regimens on central venous-to-arterial Carbon Dioxide difference (pCO 2 gap) - a randomized controlled trial

Effect of fluid resuscitation on acute lung injury in a rat model of sepsis

Fully Balanced Fluids do not Improve Microvascular Oxygenation, Acidosis and Renal Function in a Rat Model of Endotoxemia

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Evaluation of two different fluids regimens on central venous-to-arterial Carbon Dioxide difference (pCO ₂ gap) - a randomized controlled trial

Evaluation of two different fluids regimens on central venous-to-arterial Carbon Dioxide difference (pCO ₂ gap) - a randomized controlled trial