Short‐Term Tumor Control and Acute Toxicity after Stereotactic Radiosurgery for Glomus Jugulare Tumors

Poznanovic, Sheri A.; Cass, Stephen P.; Kavanagh, Brian D.

doi:10.1016/j.otohns.2005.10.040

Cited by 53 publications

(40 citation statements)

References 17 publications

(52 reference statements)

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“…23 Their incidence in the general population is only 1 in 1.3 million, and they grow very slowly. 13 Jansen and colleagues estimated the growth rate of these tumors to be 0.79 mm per year.…”

Section: Discussionmentioning

confidence: 99%

“…Acute complications such as mastoiditis, dermatitis, alopecia, mucositis, otitis, taste alterations, or cerebrovascular events have been reported in 4%-20% of patients. 23 Facial palsy, hearing loss, temporal bone or brain radionecrosis, and radiation-induced tumors have been reported as chronic complications. 23 In the 1990s, SRS began to be used for the treatment of these lesions.…”

Section: Discussionmentioning

confidence: 99%

“…23 Facial palsy, hearing loss, temporal bone or brain radionecrosis, and radiation-induced tumors have been reported as chronic complications. 23 In the 1990s, SRS began to be used for the treatment of these lesions. This is a minimally invasive therapeutic option that enables the patient to be treated in a single session with minimal radiation exposure to the surrounding healthy tissues.…”

Section: Discussionmentioning

confidence: 99%

“…23 Furthermore, significant morbidity and reduced quality of life are common downsides of surgical therapy, 11,14,16,23 with 50% of patients experiencing permanent lower cranial nerve palsies after surgery. 23 Finally, it should also be acknowledged that, according to recent publications, surgery carries a mortality rate of about 4%. 22,26 To avoid the significant morbidity associated with excision, conventional radiotherapy has been used increasingly in the treatment of JTPs.…”

mentioning

confidence: 99%

“…2,28 However, this treatment has side effects. 23 Because of its efficacy and precision, Gamma Knife radiosurgery (GKRS) has been used successfully to treat JTPs in many centers, 4,5,[7][8][9]15,19,20,24,26,29 minimizing the radiation adverse effects.…”

mentioning

confidence: 99%

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Jugulotympanic paragangliomas treated with Gamma Knife radiosurgery: a single-center review of 58 cases

Gandía-González

Kusak

Moreno

et al. 2014

JNS

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Object Jugulotympanic paragangliomas (JTPs) are rare benign tumors whose surgical treatment is usually associated with partial resection of the lesion, high morbidity, and even death. Gamma Knife radiosurgery (GKRS) has been reported as a useful treatment option. The goal of this retrospective study is to analyze the role of GKRS in tumor volume control and clinical outcomes of these patients. Methods A total of 75 patients with JTPs were treated with GKRS at the authors' center from 1995 to 2012. The authors analyzed those treated during this period to allow for a minimal observation time of 2 years. The MR images and clinical reports of these patients were reviewed to assess clinical and volumetric outcomes of the tumors. The radiological and clinical assessments, along with a group of prognostic factors measured, were analyzed using descriptive methods. The time to volumetric and clinical progression was analyzed using the Kaplan-Meier method. Prognostic factors were identified using log-rank statistics and multivariate Cox regression models. Results The mean follow-up was 86.4 months. The authors observed volumetric tumor control in 94.8% of cases. In 67.2% of cases, tumor volume decreased by a mean of 40.1% from the original size. Of patients with previous tinnitus, 54% reported complete recovery. Improvement of other symptoms was observed in 34.5% of cases. Overall, clinical control was achieved in 91.4% of cases. Previous embolization and familial history of paraganglioma were selected as significant prognostic factors for volumetric response to GKRS treatment in the univariate analysis. In multivariate analysis, no factors were significantly correlated with progression-free survival. No patient died of side effects related to GKRS treatment or tumor progression. Conclusions Gamma Knife radiosurgery is an effective, safe, and efficient therapeutic option for the treatment of these tumors as a first-line treatment or in conjunction with traditional surgery, endovascular treatment, or conventional fractionated radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Jugulotympanic paragangliomas treated with Gamma Knife radiosurgery: a single-center review of 58 cases

Gandía-González

Kusak

Moreno

et al. 2014

JNS

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Radiotherapy for benign head and neck paragangliomas: A 45‐year experience

Gilbo

Morris

Amdur

et al. 2014

Cancer

104

111

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BACKGROUND: Paragangliomas of the head and neck are rare, slow-growing, generally benign tumors of neuroendocrine cells associated with the peripheral nervous system that commonly involve the carotid body, jugular bulb, vagal ganglia, and temporal bone. Treatment options include surgery, radiotherapy (RT), stereotactic radiosurgery (SRS), and observation. This article briefly reviews our 45-year institutional experience treating this neoplasm with RT. METHODS: From January 1968 through March 2011, 131 patients with 156 benign paragangliomas of the temporal bone, carotid body, jugular bulb, or glomus vagale were treated with RT at a median dose of 45 Gy in 25 fractions. The mean and median follow-up times were 11.5 years and 8.7 years, respectively. RESULTS: Five tumors (3.2%) recurred locally after RT, all within 10 years of treatment. The overall local control rates at 5 and 10 years were 99% and 96%, respectively. The cause-specific survival rates at 5 and 10 years were 98% and 97%, respectively. The distant-metastasis free survival rates at 5 and 10 years were 99% and 99%, respectively. The overall survival rates at 5 and 10 years were 91% and 72%, respectively. There were no severe complications. CONCLUSION: RT for benign head and neck paragangliomas is a safe and efficacious treatment associated with minimal morbidity. Surgery is reserved for patients in good health whose risk of associated morbidity is low. SRS may be suitable for patients with skull base tumors <3 cm where RT is logistically unsuitable. Observation is a reasonable option for asymptomatic patients with a limited life expectancy. Cancer 2014;120:3738-43.

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Definitive radiotherapy in the management of paragangliomas arising in the head and neck: A 35‐year experience

Hinerman¹,

Amdur²,

Morris³

et al. 2008

Head & Neck

134

102

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Short‐Term Tumor Control and Acute Toxicity after Stereotactic Radiosurgery for Glomus Jugulare Tumors

Abstract: C-4.

Cited by 53 publications

References 17 publications

Jugulotympanic paragangliomas treated with Gamma Knife radiosurgery: a single-center review of 58 cases

Jugulotympanic paragangliomas treated with Gamma Knife radiosurgery: a single-center review of 58 cases

Radiotherapy for benign head and neck paragangliomas: A 45‐year experience

Definitive radiotherapy in the management of paragangliomas arising in the head and neck: A 35‐year experience

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