Short-term trivalent arsenic and hexavalent chromium exposures induce gut dysbiosis and transcriptional alteration in adipose tissue of mice

Singh, D. P.; Yadav, Shiv Kumar; Patel, Kevin; Patel, Shanaya; Patil, Gajanan P; Bijalwan, Vandana; Singh, Gyanendra; Palkhade, Rajendra; Kondepudi, Kanthi Kiran; Boparai, Ravneet K.; Bishnoi, Mahendra; Das, Santasabuj

doi:10.1007/s11033-022-07992-z

Cited by 7 publications

(2 citation statements)

References 47 publications

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“…Arsenic exposure can also decrease PDE3b (phosphodiesterase 3b) expression and activity, an enzyme that regulates lipolysis and glucose uptake in adipocytes, resulting in hyperglycemia and insulin resistance [ 164 ]. In addition, SREBP (a transcription factor that regulates lipid metabolism) and PPARg (a nuclear receptor that regulates adipogenesis and glucose metabolism) have both been shown to be activated by iAs in adipocytes, resulting in increased expression of lipogenic genes and adipogenesis, eventually leading to the development of obesity, insulin resistance, and hyperglycemia [ 164 – 166 ].…”

Section: Diabetes and Arsenicmentioning

confidence: 99%

Arsenic in Drinking Water and Diabetes

Shakya

Dodson

Artiola

et al. 2023

Water

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Arsenic is ubiquitous in soil and water environments and is consistently at the top of the Agency for Toxic Substances Disease Registry (ATSDR) substance priority list. It has been shown to induce toxicity even at low levels of exposure. One of the major routes of exposure to arsenic is through drinking water. This review presents current information related to the distribution of arsenic in the environment, the resultant impacts on human health, especially related to diabetes, which is one of the most prevalent chronic diseases, regulation of arsenic in drinking water, and approaches for treatment of arsenic in drinking water for both public utilities and private wells. Taken together, this information points out the existing challenges to understanding both the complex health impacts of arsenic and to implementing the treatment strategies needed to effectively reduce arsenic exposure at different scales.

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Section: Diabetes and Arsenicmentioning

confidence: 99%

Arsenic in Drinking Water and Diabetes

Shakya

Dodson

Artiola

et al. 2023

Water

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“…Correspondingly, in an in vitro study reduced brown adipogenesis and down-regulation of UCP1 expression significantly contribute to inhibition of thermogenesis upon As exposure [ 127 ]. In addition, As-induced alterations in gut microbiota including reduced relative abundance of Lactobacilli , Bifidobacteria , Akkermansia , Lachenospiraceae , Fecalibacterium , Eubacterium , and clostridium coccoid group with increased Enterobacteriaceae abundance may contribute to inhibition of adipogenesis, lipolysis, and thermogenesis in gonadal WAT, as well as increased adipogenesis and thermogenesis in BAT, as well as systemic inflammation [ 128 ]. It is also worth mentioning that Gong et al (2021) demonstrated transgenerational effect of paternal As exposure, characterized by reduced body adiposity in F2 offspring and increased susceptibility to diet-induced increase in body adiposity in F3 offspring [ 129 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches

Martins

Ferrer

Tinkov

et al. 2023

Toxics

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Metabolic syndrome (MetS) is an important public health issue that affects millions of people around the world and is growing to pandemic-like proportions. This syndrome is defined by the World Health Organization (WHO) as a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. Moreover, the etiology of MetS is multifactorial, involving many environmental factors, including toxicant exposures. Several studies have associated MetS with heavy metals exposure, which is the focus of this review. Environmental and/or occupational exposure to heavy metals are a major risk, contributing to the development of chronic diseases. Of particular note, toxic metals such as mercury, lead, and cadmium may contribute to the development of MetS by altering oxidative stress, IL-6 signaling, apoptosis, altered lipoprotein metabolism, fluid shear stress and atherosclerosis, and other mechanisms. In this review, we discuss the known and potential roles of heavy metals in MetS etiology as well as potential targeted pathways that are associated with MetS. Furthermore, we describe how new approaches involving proteomic and transcriptome analysis, as well as bioinformatic tools, may help bring about an understanding of the involvement of heavy metals and metalloids in MetS.

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Probiotics Pediococcus acidilactici GR-1 promotes the functional strains and remodels gut microbiota to reduce the Cr(VI) toxicity in a dual-chamber simulated intestinal system

Wang,

et al. 2024

Chemosphere

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Short-term trivalent arsenic and hexavalent chromium exposures induce gut dysbiosis and transcriptional alteration in adipose tissue of mice

Cited by 7 publications

References 47 publications

Arsenic in Drinking Water and Diabetes

Arsenic in Drinking Water and Diabetes

Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches

Probiotics Pediococcus acidilactici GR-1 promotes the functional strains and remodels gut microbiota to reduce the Cr(VI) toxicity in a dual-chamber simulated intestinal system

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