Short-term toxicity of furfuryl mercaptan in rats

Phillips, John C.; Gaunt, I.F.; Hardy, Joan; Kiss, Ida S.; Gangolli, S.D.; Butterworth, K.R.

doi:10.1016/s0015-6264(77)80002-3

Cited by 17 publications

(44 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NOAEL of 2-furanmethanethiol in a multiple dose level 91-day oral gavage study with rats was 3 mg/kg bw/day (Phillips et al, 1977 Subgroup IIc disulphides 13.144,13.178 and 13.185]:…”

Section: Application Of the Procedures For The Safety Evaluation Of Flmentioning

confidence: 99%

“…However, after fission of the disulphide bridge the resulting furan-containing fragment, which is more reactive than the disulphide itself, could be evaluated by comparison with the toxicity of furfuryl mercaptan .026] from subgroup IIb. The NOAEL of furfuryl mercaptan in a multiple dose level 91-day oral gavage study with rats was 3 mg/kg bw/day (Phillips et al, 1977 ]. The latter substance has been assigned the JECFA number 1524 in the report of the 69 th meeting (JECFA, 2009a).…”

Section: Application Of the Procedures For The Safety Evaluation Of Flmentioning

confidence: 99%

“…These fission products are [FL no: 13.055] and ], for which NOAELs of 5 mg/kg bw/day and 3 mg/kg bw/day, respectively, have been derived (Oser, 1970b;Phillips et al, 1977). Exposure to The one candidate flavouring substance in this subgroup methyl furfuryl trisulphide ] is a trisulphide which may be anticipated to release perthiols upon metabolism.…”

Section: Application Of the Procedures For The Safety Evaluation Of Flmentioning

confidence: 99%

See 2 more Smart Citations

Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14

Flavourings¹

2011

EFSA Journal

View full text Add to dashboard Cite

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 27 flavouring substances in the Flavouring Group Evaluation 13, Revision 2, using the Procedure in Commission Regulation (EC) No 1565/2000. Three of the substances [Fl‐no: 13.125, 13.155 and 13.162] were considered to have genotoxic potential. The remaining 24 substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure‐activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that the 24 substances do not give rise to safety concerns at their levels of dietary intake, estimated on the basis of the MSDI approach. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered. Adequate specifications including complete purity criteria and identity for the materials of commerce have been provided for all 24 flavouring substances evaluated through the Procedure.

show abstract

“…The NOAEL of 2-furanmethanethiol in a multiple dose level 91-day oral gavage study with rats was 3 mg/kg bw/day (Phillips et al, 1977 Subgroup IIc disulphides 13.144,13.178 and 13.185]:…”

Section: Application Of the Procedures For The Safety Evaluation Of Flmentioning

confidence: 99%

Section: Application Of the Procedures For The Safety Evaluation Of Flmentioning

confidence: 99%

Section: Application Of the Procedures For The Safety Evaluation Of Flmentioning

confidence: 99%

See 1 more Smart Citation

Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14

Flavourings¹

2011

EFSA Journal

View full text Add to dashboard Cite

show abstract

“…Comparison of the only level tested with no effect taken as a no observed adverse effect level (NOAEL) with the estimated daily per capita intakes based on the MSDI approach and expressed in microgram/kg bw/day for ethyl furfuryl sulfide The candidate substances 5-methyl-2-furanmethanethiol [FL-no: 13.149] is structurally related to the supporting substance 2-furanmethanethiol [FL-no: 13.026]. The NOAEL of 2-furanmethanethiol in a multiple dose level 91-day oral gavage study with rats was 3 mg/kg bw/day (Phillips et al, 1977).…”

Section: ]mentioning

confidence: 99%

“…These fission products are [FL no: 13.055] and [FL-no: 13.026], for which NOAELs of 5 mg/kg bw/day and 3 mg/kg bw/day, respectively, have been derived (Oser, 1970b;Phillips et al, 1977 The one candidate flavouring substance in this subgroup methyl furfuryl trisulphide ] is a trisulphide which may be anticipated to release perthiols upon metabolism. Similar reactive products may be anticipated for bis-(2-methyl-3-furyl)tetrasulphide .017] for which a NOAEL of 0.56 mg/kg bw/day in a 90-day study has been derived (Morgareidge and Oser, 1970f The Panel also agrees with the conclusion reached by the JECFA at its 55 th meeting (JECFA, 2001b) that substance .031] can be evaluated using the Procedure, and that this substances poses no safety concern when used as a flavouring substance.…”

Section: ]mentioning

confidence: 99%

Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by J

Flavourings¹

2011

EFSA Journal

View full text Add to dashboard Cite

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present consideration concerns a group of 33 furan‐substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by the JECFA. In the present version of FGE.67 eight additional substances have been included. The substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure‐activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. For twenty‐two substances [FL‐no: 13.029, 13.030, 13.045, 13.052, 13.054, 13.059, 13.061, 13.066, 13.069, 13.070, 13.083, 13.092, 13.101, 13.103, 13.105, 13.106, 13.107, 13.123, 13.138, 13.148, 13.163 and 13.191] a concern for genotoxicity was raised and therefore these were not evaluated using the Procedure. The Panel concluded that 8 substances [FL‐no: 13.006, 13.021, 13.022, 13.023, 13.024, 13.074, 13.116 and 13.190] do not give rise to safety concerns at the levels of dietary intake, estimated on the basis of the MSDI approach. For one substance [FL‐no: 13.058] additional toxicity data are requested. Besides the safety assessment of these substances, the specifications for the materials of commerce have been considered. For three substances [FL‐no: 13.031, 13.045 and 13.047] data on specifications / stereoisomerism are missing.

show abstract

Toxicity of aromatic disulphides. III. In vivo haemolytic activity of aromatic disulphides

Munday¹,

Manns²

1985

J of Applied Toxicology

View full text Add to dashboard Cite

Diphenyl disulphide, 4,4'-diaminodiphenyl disulphide, 2,2'-diaminodiphenyl disulphide, 4,4'-dimethyldiphenyl disulphide and 4,4'-dinitrodiphenyl disulphide, when administered orally to rats, induced haematological and pathological changes indicative of erythrocyte destruction in vivo. No evidence of haemolysis was detected, however, in animals receiving diphenyl disulphide-2,2'-dicarboxylic acid or dibenzyl disulphide. The order of activity of the various aromatic disulphides in provoking in vivo haemolysis was similar to that previously recorded for 'active oxygen' generation and erythrocyte damage in vitro. The results of this investigation suggest that in vivo haemolysis may be anticipated from any disulphide or thiol which undergoes appreciable autoxidation at neutral pH. While aromatic or alpha beta-unsaturated thiols and disulphides would be expected to be the most active haemolytic agents, other thiols or disulphides may precipitate the destruction of erythrocytes whose defences against oxidative attack are deficient.

show abstract

Short-term toxicity of furfuryl mercaptan in rats

Cited by 17 publications

References 3 publications

Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14

Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14

Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by J

Toxicity of aromatic disulphides. III. In vivo haemolytic activity of aromatic disulphides

Contact Info

Product

Resources

About