Short-term tolerance of pulse methylprednisolone therapy in patients with diabetes mellitus

Feldman–Billard, S.; Lissak, B.; Kassaei, R.; Benrabah, R.; Héron, Emmanuel

doi:10.1016/j.ophtha.2004.10.032

Cited by 33 publications

(13 citation statements)

References 18 publications

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“…In our study, the four subjects who required insulin therapy for correction of hyperglycemia were all diabetics. Similarly in a large study by Feldman-Billard et al [ 10 ], the authors found that methylprednisolone therapy resulted in raised glucose levels, but the effects were different in nondiabetics and diabetics. In nondiabetics, the hyperglycemia was maximum after first pulse and returned to baseline with subsequent pulses, but diabetic patients had cumulative effects of the hyperglycemia with repeated pulses, and a quarter of the diabetic patients required insulin.…”

Section: Discussionmentioning

confidence: 83%

“…IVMP may also cause hyperglycemia, especially in diabetic patients and transient deranged liver enzymes; thus careful screening of patient's glucose levels and liver function should be performed prior to IVMP administration [ 10 , 38 ]. In our study, the four subjects who required insulin therapy for correction of hyperglycemia were all diabetics.…”

Section: Discussionmentioning

confidence: 99%

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Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease

Yong

Chng

Htoon

et al. 2015

International Journal of Endocrinology

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Objective. To analyze changes in vital signs (heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP)) during and after intravenous methylprednisolone (IVMP) and any other adverse effects. Methods. Retrospective review of charts of patients who received IVMP as treatment regime for thyroid eye disease. All subjects had vital signs charted during and after infusions. Results. This study included 38 subjects and a total of 242 infusions administered. IVMP resulted in a small but significant percentage drop in mean SBP at 30 min (p < 0.001) and 60 min (p = 0.03) but no difference at 90 min. There was also small but significant percentage drop in mean DBP and HR (DBP: p < 0.001 for 30 min, p = 0.001 for 60 min, and p = 0.02 for 90 min and HR: p < 0.001 for 30 min, 60 min, and 90 min). There were no cumulative effects on change of blood pressure or HR. There were 6 episodes of bradycardia (2.5%) and 12 episodes of moderate to severe hypertension (5%). No significant cardiovascular or hepatic toxicity was found. Conclusion. IVMP is relatively safe and efficacious. IVMP demonstrated mild and noncumulative effects on vital signs. Severe hypertension may occur in susceptible individuals such as those with underlying hypertension and uncontrolled thyroid dysfunction, whereas bradycardia may be more likely in those on beta-blockers.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease

Yong

Chng

Htoon

et al. 2015

International Journal of Endocrinology

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“…Chez les patients diabétiques de l'étude, l'effet hyperglycémiant des GCS semble s'additionner et s'accompagner d'une augmentation progressive de la glycémie. Dans une autre étude portant sur 80 diabétiques de type 2 traités par GCS en bolus, Feldmann-Billard et al [35] ont montré que la glycémie à jeun initiale et le taux d'HBA1c étaient prédictifs d'un traitement par insuline (prescrite ici pour une glycé-mie > 14 mmol/L). En particulier, lorsque le taux d'HbA1c était supérieur à 8 %, une insulinothérapie était prescrite dans tous les cas.…”

Section: Diagnostic Du Diabète Cortico-induitunclassified

Corticothérapie et diabète

Gagliardi

Jeunne

2012

La Presse Médicale

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“…GCs increases by two-to fourfold the risk of hyperglycemia and diabetes in non-diabetic subjects. Treatment with exogenous GCs disrupts the glycemic balance of known diabetics [84][85][86][87].…”

Section: Hyperglycemia and Diabetesmentioning

confidence: 99%

Side Effects of Glucocorticoids

Alan¹,

Alan²

2018

Pharmacokinetics and Adverse Effects of Drugs - Mechanisms and Risks Factors

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Glucocorticoids represent the most important and frequently used class of drugs in the management of many inflammatory and immunologic conditions. Beside these beneficial effects, glucocorticoids are also associated with serious side effects. Cushing's syndrome, adrenal suppression, hyperglycemia, dyslipidemia, cardiovascular disease, osteoporosis, psychiatric disturbances, and immunosuppression are among the most important side effects of systemic glucocorticoids. These side effects are especially noticeable at high doses for prolonged periods. Even in low-dose therapy, glucocorticoids could lead to serious side effects. The underlying molecular mechanisms of side effects of glucocorticoids are complex, distinct, and frequently only partly understood. This comprehensive article reviews the current knowledge of the most important side effects of glucocorticoids from a clinical perspective.

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Short-term tolerance of pulse methylprednisolone therapy in patients with diabetes mellitus

Cited by 33 publications

References 18 publications

Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease

Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease

Corticothérapie et diabète

Side Effects of Glucocorticoids

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