Short-term tolerability of commercial eyelid cleansers: A randomised crossover study

Craig, Jennifer P.; Bitton, Etty; Dantam, Jaya; Jones, Lyndon; Ngo, William; Wang, Michael T.M.

doi:10.1016/j.clae.2022.101733

Cited by 4 publications

(8 citation statements)

References 31 publications

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“…I-Lid'n Lash ® Plus also caused a significant, yet smaller, increase in bulbar ocular redness. Patient-assessed ocular discomfort remained significantly higher than baseline for a median 195 s after applying Eye Cleanse ™ , 150 s after I-Lid'n Lash ® Plus, 120 s after Oust ™ , and 60 s after Blephadex ™ (Craig et al, 2022). Median time after which participants could comfortably open their eyes Abbreviations: ATCC, american type culture collection; ATP, adenosine triphosphate; CFU, colony forming units; CI, confidence interval; FDA, food and drug administration; ICU, intensive care unit; ISO, international organization for standardization; ITT, intention-totreat (analysis); MRSA, methicillin-resistant Staphylococcus aureus; RCT, randomised controlled trial; SD, standard deviation; SOFA, sequential organ failure assessment; TTO, tea tree oil; US, United States; VAS, visual analogue scale.…”

Section: Demodex Infestationmentioning

confidence: 89%

“…Superior Frontiers in Pharmacology frontiersin.org was one second for the saline solution, compared with 3 s for Oust ™ , 5 s for Blephadex ™ , 6 s for I-Lid'n Lash ® Plus (p < 0.05), and 30 s for EyeCleanse ™ (p < 0.001) (Craig et al, 2022). Only EyeCleanse ™ significantly increased lid wiper epitheliopathy, although all cases were resolved within 24 h and no other adverse events were recorded.…”

Section: Demodex Infestationmentioning

confidence: 92%

“…Nine studies were published in the field of infectious disease addressing hand disinfection [n = 3; (Gnatta et al, 2013;Gnatta et al, 2021;Youn et al, 2021)], MRSA decolonization [n = 4; (Caelli et al, 2000;Dryden et al, 2004;Blackwood et al, 2013;Lee et al, 2014)] or prevention of MRSA colonization [n = 1; (Blackwood et al, 2013)], molluscum contagiosum [n = 1; (Markum and Baillie, 2012)], or oral Candida infection [n = 1; (Maghu et al, 2016)]. Six studies were published in the field of ophthalmology addressing Demodex infestation [n = 4; (Koo et al, 2012;Karakurt and Zeytun, 2018;Wong et al, 2019;Craig et al, 2022)], dry eye post cataract surgery [n = 1; (Mohammadpour et al, 2020)], or meibomian gland dysfunction [n = 1; (Zarei-Ghanavati et al, 2021)]. Three studies were published in the field of podiatry addressing onychomycosis [n = 1; (Buck et al, 1994)], or tinea pedis [n = 2; (Tong et al, 1992;Satchell et al, 2002b)].…”

Section: Characteristics Of Included Trialsmentioning

confidence: 99%

“…Six trials were published in the field of ophthalmology from 2012 to 2021, and were conducted in Australia (Wong et al, 2019), Canada (Craig et al, 2022), Iran (Mohammadpour et al, 2020;Zarei-Ghanavati et al, 2021), Korea (Koo et al, 2012), or Turkey (Karakurt and Zeytun, 2018), within the hospital or outpatient clinic setting.…”

Section: Ophthalmologymentioning

confidence: 99%

“…To provide data on the tolerability of different tea tree oil-based eyelid wipe products, Craig et al (2022), compared four commercial tea tree oil-based eyelid wipes (i.e., Oust ™ Demodex ® , I-Lid'n Lash ® Plus, Blephadex ™ and Eye Cleanse ™ ) to a saline solution (i.e., Sensitive Eyes ® Plus Saline Solution), in terms of tear film break up time, as well as ocular discomfort and redness (Craig et al, 2022). Ten-minutes after application, Eye Cleanse ™ lid cleansing wipes was the only product to significantly decrease tear film break up time.…”

Section: Demodex Infestationmentioning

confidence: 99%

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Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health—A systematic review of randomized controlled trials

et al. 2023

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Introduction: Leaves of the Australian tea tree plant Melaleuca alternifolia were used traditionally by First Nations Australians for treating wounds, burns, and insect bites. Tea tree oil, the essential oil steam-distilled from M. alternifolia, is well-known for its medicinal properties, the evidence for most applications however is limited. This review aimed to critically appraise evidence from clinical trials examining the therapeutic efficacy and safety of tea tree oil on outcomes.Methods: Randomized controlled trials with participants of any age, gender, or health status, comparing tea tree oil to any control were included, without limit on publication date. Electronic databases were searched on 12 August 2022 with additional records sourced from article reference sections, reviews, and industry white papers. Risk of bias was assessed by two authors independently using the Cochrane risk-of-bias 1.0 tool. Results were summarized and synthesized thematically.Results: Forty-six articles were eligible from the following medical fields (Dentistry n = 18, Dermatology n = 9, Infectious disease n = 9, Ophthalmology n = 6, Podiatry n = 3; and Other n = 1). Results indicate that oral mouthwashes with 0.2%–0.5% tea tree oil may limit accumulation of dental plaque. Gels containing 5% tea tree oil applied directly to the periodontium may aid treatment of periodontitis as an adjunctive therapy to scaling and root planing. More evidence is needed to confirm the benefits of tea tree oil for reducing acne lesions and severity. Local anti-inflammatory effects on skin, if any, also require further elucidation. Topical tea tree oil regimens show similar efficacy to standard treatments for decolonizing the body from methicillin-resistant Staphylococcus aureus, although intra-nasal use of tea tree oil may cause irritation to mucous membranes. Tea tree oil with added iodine may provide an effective treatment for molluscum contagiosum lesions in young children. More evidence on efficacy of tea tree oil-based eyelid wipes for Demodex mite control are needed. Side effects were reported in 60% of included studies and were minor, except where tea tree oil was applied topically in concentrations ≥ 25%.Discussion: Overall, the quality of research was poor to modest and higher quality trials with larger samples and better reporting are required to substantiate potential therapeutic applications of tea tree oil.Systematic Review Registration: PROSPERO, identifier [CRD42021285168].

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Section: Demodex Infestationmentioning

confidence: 89%

Section: Demodex Infestationmentioning

confidence: 92%