Short‐term Therapy with Celecoxib and Lansoprazole Modulates Th1/ Th2 Immune Response in Human Gastric Mucosa

Larussa, Tiziana; Suraci, Evelina; Leone, Isabella; Nazionale, Immacolata; Abenavoli, Ludovico; Galasso, Olimpio; Amorosi, Andrea; Imeneo, Maria; Luzza, Francesco

doi:10.1111/j.1523-5378.2010.00796.x

Cited by 11 publications

(9 citation statements)

References 32 publications

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“…It has been previously demonstrated that prostaglandins stimulate the production of IL-6 by bone cells 33 . This hypothesis is in agreement with the observation that OA patients treated with celecoxib exhibit decreased IL production in the gastric mucosa 34 . Therefore, the effect of NSAIDs on the IL-6 concentration is unlikely to be tissue specific.…”

Section: Discussionsupporting

confidence: 93%

The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial

Gallelli

Galasso

Falcone

et al. 2013

Osteoarthritis and Cartilage

117

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Section: Discussionsupporting

confidence: 93%

The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial

Gallelli

Galasso

Falcone

et al. 2013

Osteoarthritis and Cartilage

117

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“…In contrast, other studies even proposed an association between the intake of PPIs and decreased tumorigenesis, which in some of these studies was beyond the mucosa healing e ect of the drugs [61,62]. Further more, lansoprazole treatment was described to down-regulate 1 and 2 signaling pathways in the human gastric mucosa [63] and to be associated with decreased levels of proin ammatory cytokines such as interleukin(IL-)6, IL-8 and tumor necrosis factor-(TNF-)α in cultured tracheal epithelial cells [64]. Interestingly, PPIs were also reported to inhibit IL-4 and IL-13 signaling via STAT6 (signal transducer and activator of transcription 6) [65] and in PPI-REE a marked reduction of eotaxin-3, IL-13, IL-5 mRNA expression was observed a er PPI treatment [66].…”

Section: Acid Suppression Medication and The Immune Responsementioning

confidence: 79%

Acid suppression therapy and allergic reactions

Untersmayr¹

2015

Allergo J

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e development of pharmaceutical agents reducing gastric acidity such as sucralfate, histamine 2 (H2) receptor blockers, and proton pump inhibitors (PPIs) has been a milestone for the treatment of dyspeptic disorders. However, due to current prescription habits resulting in overuse of these potent drugs as well as over-the-counter (OTC) availability associated with self-medication, substantial health concern is related to the mechanisms of drug action as well as known side e ects in uencing gastrointestinal physiology. More than a decade ago, the rst study appeared reporting an association between anti-ulcer drug intake and food allergy development. Since then, several experimental and human studies veri ed this correlation, demonstrating that acid suppressive drugs not only in uence the sensitization capacity of orally ingested proteins, but also represent a risk factor for food allergic patients. Additionally, gastric acid suppression was reported to increase the risk for development of drug hypersensitivity reactions. ese consequences of anti-ulcer drug intake might on the one hand be associated with direct in uence of these drugs on immune responses. On the other hand reduction of gastric acidity leads to impaired gastrointestinal protein degradation. Nevertheless, also disruption of the gastrointestinal barrier function, changes in microbiome, or lack of tolerogenic peptic digests might contribute to the connection between anti-ulcer drug intake and allergic reaction. erefore, these drugs should only be prescribed based on a precise gastroenterological diagnosis taking into consideration allergological mechanisms to ensure patients' safety.Cite this as: Untersmayr E. Acid suppression therapy and allergic reactions.

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“…Third, the host immune response to high‐dose proton‐pump inhibitors (PPIs) in HP eradication regimens must be considered. PPIs may directly affect the immune response via the inhibition of gastric acid production . It has been shown that exposure to acid enhances the expression of adhesion molecules and cytokines, such as IL‐8 and IL‐1β, which in turn increases the inflammation and thus possibly recruiting immune cells .…”

Section: Discussionmentioning

confidence: 99%

“…PPIs may directly affect the immune response via the inhibition of gastric acid production. [55][56][57][58] It has been shown that exposure to acid enhances the expression of adhesion molecules and cytokines, such as IL-8 and IL-1β, which in turn increases the inflammation and thus possibly recruiting immune cells. 59,60 Therefore, acid reduction via PPIs may reduce these responses and also minimize food allergen simulation caused by acid-induced damage to the gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta‐analysis: Effect ofHelicobacter pylorieradication on chronic spontaneous urticaria

Kim

Lee

et al. 2019

Helicobacter

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Background Helicobacter pylori (HP) infection is considered to play a role in the pathogenesis of chronic spontaneous urticaria (CSU). However, the efficacy of HP eradication therapy on CSU symptom improvement has not been well established. This meta‐analysis was conducted to estimate the association between HP infection and CSU and to evaluate whether HP eradication therapy benefits patients with CSU. Material and Methods In October 2018, we searched databases for studies investigating the efficacy of HP eradication therapy for patients with CSU. Risk ratios (RRs) and 95% confidence intervals (CIs) were pooled using random effects models. Results The meta‐analysis included 22 studies with a total of 1385 patients with CSU. When comparing the spontaneous remission of urticarial symptom in patients with HP‐positive to HP‐negative patients, HP‐negative patients showed significantly higher spontaneous remission of urticarial symptoms. (risk ratio 0.39; 95% confidence interval: 0.19‐0.81). Among HP‐positive CSU patients, remission of CSU was more likely shown in HP eradication therapy group compared to untreated group, aside from achieving HP elimination (risk ratio 2.10; 95% confidence interval: 1.20‐3.68). However, there was no significant difference in the remission of CSU whether antibiotic therapy was successful in eradication of HP or not (risk ratio 1.00; 95% confidence interval: 0.65‐1.54). Conclusions The results of this meta‐analysis show that HP might be associated with the occurrence and persistence of CSU. The effectiveness of HP eradication therapy in suppressing CSU symptoms was significant. Interestingly, we found that resolution of CSU was not associated with successful eradication of HP infection. CSU Patients who were undergone antibiotic therapy for HP eradication showed significant higher CSU remission with or without HP eradication. Further studies are recommended to evaluate the mechanisms associated with relation of HP with CSU.

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Short‐term Therapy with Celecoxib and Lansoprazole Modulates Th1/ Th2 Immune Response in Human Gastric Mucosa

Abstract: Celecoxib and lansoprazole modulate Th1/Th2 immune response in human gastric mucosa. The use of these drugs may interfere with long-term course of gastritis.

Cited by 11 publications

References 32 publications

The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial

The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial

Acid suppression therapy and allergic reactions

Systematic review and meta‐analysis: Effect ofHelicobacter pylorieradication on chronic spontaneous urticaria

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