Short term testosterone replacement therapy improves libido and body composition

Abstract

Objective: To assess the efficacy and safety of testosterone replacement in males with late-onset hypogonadism compared to hypogonadal men without replacement, and controls, during six months. Methods: We assessed, through ADAM, AMS, IIEF-5 and SF-36 questionnaires, and through clinical and laboratorial examinations, 62 patients divided into three groups: 17 hypogonadal males (HR) used intramuscular testosterone every three weeks; 14 hypogonadal males (HV) and 31 non-hypogonadal males (CV) used oral vitamins daily. Results: When compared to others, HR group obtained libido improvement assessed by ADAM 1 (p = 0.004), and borderline sexual potency improvement assessed by IIEF-5 (p = 0.053), besides a decrease in waist circumference after eight weeks (p = 0.018). The remaining parameters did not differ between the groups. PSA and hematocrit remained stable in those using testosterone. Conclusion: Six months of testosterone replacement improved sexuality and body composition, with prostatic and hematological safety. KeywordsTestosterone replacement therapy; late onset hypogonadism; andropause; libido; body composition; waist circumference resumo Objetivo: Avaliar a eficácia e a segurança da reposição de testosterona em homens com hipogonadismo tardio comparados a hipogonádicos sem reposição e controles, durante seis meses. Métodos: Mediante os questionários ADAM, AMS, IIEF-5 e SF-36, foram feitos exame clínico e laboratorial em 62 pacientes divididos em três grupos: 17 hipogonádicos (HR) usaram testosterona intramuscular a cada três semanas; 14 hipogonádicos (HV) e 31 não hipogonádi-cos (CV) usaram vitaminas via oral diariamente. Resultados: Comparado aos demais, o grupo HR obteve melhora da libido avaliada pelo ADAM 1 (p = 0,004) e melhora limítrofe da potência sexual avaliada pelo IIEF-5 (p = 0.053), além de diminuição da cintura a partir da oitava semana (p = 0,018). Os demais parâmetros não foram diferentes entre os grupos. PSA e hematócrito se mantiveram estáveis nos que usaram testosterona. Conclusão: A reposição de testosterona durante seis meses melhorou a sexualidade e a composição corporal, com segurança prostática e hematológica. Arq Bras Endocrinol Metab. 2009;53(8):996-1004 Descritores

The Effect of Testosterone Replacement Therapy on Prostate-Specific Antigen (PSA) Levels in Men Being Treated for Hypogonadism

“…Of the studies included in this meta-analysis, the earliest was performed in 1997 by Sih et al, 30 who studied hypogonadal men with a mean age of 68 years and reported that testosterone supplementation (200 mg testosterone cypionate biweekly for 12 months) improved strength, increased hemoglobin levels, and lowered leptin levels. Andrade et al 2 also treated hypogonadal men with IM testosterone for 6 months and reported an improvement in body composition. Chiang et al 23 and Park et al 4 both reported that testosterone replacement improved quality of life and sexual function in men with testosterone deficiency.…”

THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study

“…Data on body composition were provided but the study was excluded since hypogonadism was artificially induced in healthy men by the use of GnRH agonist (136) Cross-over RCT of the effects of T patch (50 mg/day) and sildenafil for 8 weeks on sexual function in hypogonadal men with erectile dysfunction. The combined therapy with PDE5 and T or placebo can influence the outcomes of the study (137) Observational cohort study before and after study between two groups of participants receiving T (T cyprionate 200 mg/3 weeks) or not. There are not data about circulating T both in baseline and at the end of the study.…”

Modifying Risk Factors in the Management of Erectile Dysfunction: A Review

“…The basic science literature has confirmed the necessity of androgens to generate adequate intracavernosal pressures and smooth muscle function to obtain an erection [59]. The literature showing the impact of testosterone replacement therapy (TRT) on erectile function is quite heterogenous (Table 1) [6061626364656667686970717273747576777879808182838485868788899091]. A subset analysis of the Olmstead County Cohort published by Gades et al [92] showed that testosterone has a statistically significant positive correlation with erectile function, even when adjusted for age.…”